. accuracy . These findings will provide promising data for lung cancer patient stratification, precise prognostic assessment, and personalized treatment
PNAS: Previously little-known protein involved in metabolic pathway required for cancer cell survival
Time of Update: 2022-01-24
But now that its important role in AML cells has been discovered, Polyanskaya said, "Other researchers can use this system, tweak some other things, and really try and pinpoint the exact pathway .
Nat Metab Rao Feng/Dynasty's team discovered a new messenger in the GPCR pathway that regulates vesicle secretion and metabolic homeostasis: IP7
Time of Update: 2021-11-04
Rao Feng's research group from the School of Life Sciences of Southern University of Science and Technology is mainly studying the functional mechanism of emerging small molecule messengers in cells represented by high-grade inositol polyphosphate .
Antimony-reducing bacteria in paddy soil and their potential metabolic pathways revealed
Time of Update: 2021-11-01
Photo courtesy of Sun Weimin team arrA anrA arrA anrA https://doi.
system: revealing the transcellular transmission pathway of metabolic signals between oligodendrocytes and neuron axons
Time of Update: 2021-10-02
to label the ATP levels in axons in real time, it was found that the ATP levels in neuronal axons increased significantly after co-culture . A previous article reported
Grape seed extract improves the colon injury induced by PhIP in rats by regulating the intestinal flora, lipid metabolism and NF-κB signaling pathway
Time of Update: 2021-03-17
. >Focus:>Grape seed extract (GSE) improves 2-Amino
Co-expression Analysis of Metabolic Pathways in Plants
Time of Update: 2021-03-15
This chapter explains how to use a Web-based tool (CressExpress) to investigate co-expression of genes involved in metabolic pathways inArabidopsis .
From Metabolic Reactions to Networks and Pathways
Time of Update: 2021-02-21
This chapter introduces well-known topological transformations from metabolic reactions to a graph, and discusses their advantages and disadvantages.
Metabolic Pathway Determination and Flux Analysis in Nonmodel Microorganisms Through 13C-Isotope Labeling
Time of Update: 2021-02-01
absolute carbon fluxes through the metabolic network of interest. This technique can be widely used for functional characterization of nonmodel microbial species, and thus we provide a13 C-pathway and flux analysis protocol. The five key
Targeted Proteomics for Metabolic Pathway Optimization
Time of Update: 2021-01-25
SRM methods provide high selectivity and high sensitivity to enable rapid quantification of multiple proteins in an engineered pathway regardless of sequence or organism of origin.
Systems Approaches to Unraveling Plant Metabolism: Identifying Biosynthetic Genes of Secondary Metabolic Pathways
Time of Update: 2021-01-17
The diversity of useful compounds produced by plant secondary metabolism has stimulated broad systems biology approaches to identify the genes involved in their biosynthesis. Systems biology studies in non-model plants pose interesting
Combinatorial Genetic Transformation of Cereals and the Creation of Metabolic Libraries for the Carotenoid Pathway
Time of Update: 2021-01-17
The principle of combinatorial nuclear transformation is demonstrated in this chapter through protocols developed in our laboratory that allow combinations of genes encoding enzymes in the carotenoid biosynthesis pathway to be introduced into rice and a white-endosperm variety of corn.
Deducing Intracellular Distributions of Metabolic Pathways from Genomic Data
Time of Update: 2021-01-14
Additionally, we describe strategies suitable for those groups of algae with secondary plastids (for instance diatoms), which are characterized by a different cellular topology and a larger number of intracellular compartments compared to plants.
Techniques for Determining the Metabolic Pathways of Eicosanoids and for Evaluating the Rate-Controlling Enzymes
Time of Update: 2020-12-05
One enzyme with extensive involvement in arachidonic acid formation in response to inflammatory stimuli in many cell types is 14 kDa secretory PLA 2 (sPLA 2 ).
Elucidation of Metabolic Pathways from Enzyme Classification Data
Time of Update: 2020-11-21
AReactions Database has been created from the material in theEnzyme List to allow reactions to be searched by substrate/product, and pathways to be traced from any selected starting/seed substrate.
Putting the Plant Metabolic Network Pathway Databases to Work: Going Offline to Gain New Capabilities
Time of Update: 2020-11-20
Metabolic databases such as The Plant Metabolic Network/MetaCyc and KEGG PATHWAY are publicly accessible resources providing organism-specific information on reactions and metabolites.
Metabolic Engineering of Glyoxalase Pathway for Enhancing Stress Tolerance in Plants
Time of Update: 2020-11-20
Gly I detoxifies methylglyoxal (MG), a cytotoxic byproduct of glycolysis, to S-lactoylglutathione (SLG) where it uses one molecule of reduced glutathione.
How is the mTOR pathway involved in metabolic regulation?
Time of Update: 2020-08-11
here by amino acids directly activated mTOR regulatory mode, although not through the signal from the cell surface, but also by the small G protein Rags mediated.