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Immunity Zhejiang University Jin Jin/Cao Qian discovered selenium as a potential treatment for patients with Crohn's disease
Time of Update: 2021-10-02
On August 2, 2021, Jin Jin and Cao Qian of Zhejiang University jointly published a research paper entitled "Multiomics analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn's disease" in Immunity.
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Immunity: Zhejiang University Jin Jin/Cao Qian team reveals a new mechanism by which trace element selenium regulates T cell differentiation
Time of Update: 2021-10-02
The study identified disease-specific immune cell subsets and altered metabolites in newly diagnosed inflammatory bowel disease (IBD) patients, and analyzed the new mechanism of trace element selenium regulating the differentiation of type I helper T (Th1) cells, which is Crohn’s disease ( CD) treatment provides potential new targets .
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Immunity Jin Jin/Cao Qian collaborate to analyze the mechanism of selenium deficiency in Crohn’s disease that leads to T cell differentiation disorder
Time of Update: 2021-10-02
In-depth mechanism studies have shown that in Th1 cells, selenium mainly regulates one-carbon metabolism through selenoprotein W (SELW) and the purine salvage pathway mediates the removal of reactive oxygen species (ROS) in the cytoplasm, thereby affecting NF -Activation of κB signaling pathway inhibits the production of IFN-γ .
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Nat Immunol Liu Zheng/Yu Di collaborated to report that daily dietary selenium supplementation can
Time of Update: 2021-10-02
On the contrary, daily dietary selenium supplementation can up-regulate the selenoprotein GPX4, protect TFH cells from iron death, and enhance antibody immune response .
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Zhejiang University Immunity published a paper: Explaining the new mechanism of selenium regulating T cell differentiation
Time of Update: 2021-08-15
2021 Nian 8 Yue 2 days, Jin Jin Hospital Task Force and Run Run Shaw Hospital, Zhejiang University, Cao Qian Task Force in cooperation Immunity published online entitled "Multiomic analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn's disease" The research paper analyzed the mechanism by which trace element selenium regulates the differentiation of Th1 cells in CD patients .
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JBC: selenium compounds enhance the immune system against cancer
Time of Update: 2014-11-27
Cancers such as melanoma, prostate cancer and certain types of leukemia weaken the body by over activating the natural immune system Now researchers at the University of Copenhagen have shown that nat
