molecule RGF7 of RGF1 is induced by pathogenic bacteria in Arabidopsis leaves, but RGF1 and other 9 RGF family members are not induced by pathogenic bacteria.
New Phytologist | Meng Xiangzong's research team discovered a new type of plant immunity-inducing peptides and their receptors!
Time of Update: 2021-03-25
for the perception of root meristem growth factor 1 in Arabidopsis thaliana. Cell Res26(6): 686-698. Plant Biotechnology Pbj Exchange Group In order to more effectively help the majority of scientific researchers to obtain relevant
Shanghai Normal University Meng Xiangzong's research group discovered new plant immunity-inducing small peptides and their receptors
Time of Update: 2021-03-25
kinases RGI4 and RGI5 expressed in Arabidopsis leaves, while the SERK (Somatic Embryogenesis Receptor Kinase) family receptor kinases BAK1 and SERK4 acted as co-receptors. The body, interacts with RGI4/RGI5 to form a receptor protein complex
Express | "first-in-class" peptide-conjugated drug has been approved by the FDA for accelerated treatment of multiple myeloma
Time of Update: 2021-03-24
▎WuXi AppTec content team editor recently, Oncopeptides announced that the US FDA has accelerated the approval of Pepaxto (melphalan flufenamide, also known as melflufen) to be marketed in combination with dexamethasone to treat relapsed/refractory multiple myeloma (MM) Adult patients.
Sub-Journal of Nature: What are the trends in peptide drug discovery?
Time of Update: 2021-03-24
75em;box-sizing:border-box !important;overflow-wrap:break-word !important;'>544px;">544px;">544px;text-align:justify;white-space:normal;font-family:-apple-system-font, system-ui, "Helvetica Neue", "PingFang SC", "Hiragino Sans GB", "Microsoft YaHei UI", "Microsoft YaHei", Arial, sans-serif;background-color:#FFFFFF;line-height:1.
"First-in-class" peptide-conjugated drug obtained accelerated FDA approval; Eli Lilly's innovative diabetes treatment reached phase 3 clinical endpoint
Time of Update: 2021-03-23
"Baricitinib is currently in another phase 3 clinical trial for the treatment of patients with alopecia areata, and the results are expected to be announced in the first half of this year.
Linkers, Resins, and General Procedures for Solid-Phase Peptide Synthesis
Time of Update: 2021-03-07
The chapter finishes with robust protocols for general solid-phase peptide synthesis, i.e., the standard operations.
Calibration of Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Peptide Mass Fingerprinting Spectra
Time of Update: 2021-03-05
Both multipoint internal calibration and mass defect-based calibrationis illustrated.
Furthermore, the construction of project/user-specificlists of potential calibrants is illustrated.
Asymmetric Syntheses of Unnatural Amino Acids and Hydroxyethylene Peptide Isosteres
Time of Update: 2021-03-04
Chiral glycine equivalents serve as useful α-amino acid templates undergoing homologationvia carbon-carbon bond formation at the α-position through nucleophilic carbanion alkylation (2) or electrophilic carbocation substitution (3).
Assembly of PNA-Tagged Small Molecules, Peptides, and Carbohydrates onto DNA Templates: Programming the Combinatorial Pairing and Inter-ligand Distance
Time of Update: 2021-03-03
Additionally, the ability to programdifferent permutations of ligand assemblies in a combinatorial fashion provides access to a broad diversity and offers a rapidscreening method for fragment based approaches to drug discovery.
Lipid-Core-Peptide System for Self-Adjuvanting Synthetic Vaccine Delivery
Time of Update: 2021-03-01
However, vaccines based on minimal epitopes suffer from poor immunogenicity and require the use of an additional immunostimulant (adjuvant).
Radiolabeling of Peptides and Proteins
Time of Update: 2021-03-01
activity available (Table 1)There is an mverse relationshtp between the half hfe of an isotope and its theoretical specific activity. In some Isotopesthis maximum is never obtamable. [125I] Iodme
Nutritional Value of d-Amino Acids, d-Peptides, and Amino Acid Derivatives in Mice
Time of Update: 2021-02-28
The method is generally applicable to the determination of the biological utilization and safety of any amino acid derivative as a potential nutritional source of the correspondingl -amino acid.
Characterizing Proteins from 2-DE Gels by Internal Sequence Analysis of Peptide Fragments: Strategies for Microsample Handling
Time of Update: 2021-02-27
Considerable effort has also been expended to interface in situ digestion with micro-liquid chromotography (LC), peptide sequencers, and mass spectrometers.
(E)-Alkene Peptide Bond Isosteres by Cuprate Opening of Vinyl Aziridines
Time of Update: 2021-02-26
Alkene isosteres are important nonhydrolyzable and rigidified analogs of peptide bonds.
Fig. 1. Geometry of peptide bond and alkene isostere.
