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New progress in targeted protein degradation!

 Time of Update: 2022-05-24

▲The mechanism of action of AUTOphagy-TArgeting Chimera (AUTOTAC) (Image source: Reference [1])Based on this concept, the researchers developed a variety of small-molecule compounds capable of activating p62 and tested their ability to degrade soluble proteins in vitro .
Brain: Glial fibrillary acidic protein and neurofilament light chain levels 8 months after brain trauma predict brain structural changes 5 years later

 Time of Update: 2022-05-24

and whole brain white matter in subgroups of patients who showed improvement (1 point increase in GOSE), stable (no change in GOSE), or worsening (1 point decrease in GOSE) between 8 months and 5 years after injury (Fig. A and B) and predicted
Alzheimer & Dementia: These plasma proteins are linked to cognitive decline and long-term risk of dementia

 Time of Update: 2022-05-23

To this end, experts from the Department of Epidemiology and Public Health at UCL, UK, examined the association between 4,953 plasma proteins and the risk of cognitive decline and dementia in two cohort studies followed for 20 years.
Blueprint Announces Strategic Collaboration with Proteovant to Develop Targeted Protein Degradation Therapies

 Time of Update: 2022-05-23

On February 28, 2022, Blueprint Medicines announced a strategic collaboration with Proteovant Therapeutics, a Roivant Sciences company, to discover and develop novel targeted protein degradation therapies aimed at addressing unmet medical needs in cancer and hematological diseases .
Studies show that a diet rich in protein, zinc and niacin, and low in saturated fat leads to better blood vessels

 Time of Update: 2022-05-20

A new study presented at the European Congress on Obesity (ECO) in Maastricht, The Netherlands (May 4-7) links key nutrients including protein, zinc and niacin to improved heart health up .
of DndE, an important protein in the archaeal DNA phosphorylation modification pathway

 Time of Update: 2022-05-18

Recently, Professor Wu Geng's team from the School of Life Science and Technology of Shanghai Jiao Tong University and the State Key Laboratory of Microbial Metabolism collaborated
New progress has been made in the research on the microbial mechanism of metabolic protein

 Time of Update: 2022-05-18

　　Improving production efficiency and reducing environmental pollution are the two main challenges facing the grass-fed livestock industry .
DNA has special significance in iodine cleavage reaction and SBD protein recognition

 Time of Update: 2022-05-18

of chemical reactions, resulting in DNA backbone cleavage or sulfur-oxygen conversion at the sulfur modification site, revealing that Molecular mechanism of highly selective splicing of sulfur-modified sites in deep sequencing by iodine cleavage
South China Botanical Garden "CsHAC1 gene and protein of tea tree and its application" won the invention patent

 Time of Update: 2022-05-18

>　　It was learned on April that the "Tea CsHAC1 Gene and Protein and Its
Announcement of latest persistence and booster data for Clover's new coronary pneumonia adjuvanted protein vaccine

 Time of Update: 2022-05-18

A new dataset from an extended follow-up analysis confirms earlier findings and shows high and durable protection in individuals approximately 6 months after basal immunization with SCB-2019 (CpG 1018/aluminum adjuvant) .
ACS Omega: New coronavirus changes male fertility-related protein levels, and the changes persist after recovery

 Time of Update: 2022-05-17

analyzed protein levels in the semen of men who had recovered from Covid-19 and found that even those with mild or moderate symptoms had significantly lower sperm counts and motility after recovery, fewer normal-shaped sperm, and less Reproductive
Unexpected protein may be messing with your brain

 Time of Update: 2022-05-17

> Left: The protein TMEM106B, with golf course-like folds .
mechanism of zinc ions regulating Tau protein phase separation and cytotoxicity

 Time of Update: 2022-05-17

research results of Prof. Yi Liang online in the form of a Research Article, titled "Zinc enhances liquid-liquid phase separation of Tau protein and aggravates mitochondrial "damages in cells" (zinc ions promote the liquid-liquid phase
protein that prevents the pancreas from digesting itself

 Time of Update: 2022-05-17

Now, Salk scientists report in the April 21, 2022, issue of Gastroenterology that a protein called estrogen-related receptor gamma (ERR?) protects the pancreas in mice against Autodigestion is critical .
Bone growth protein offers hope for newborns with rare lung disease

 Time of Update: 2022-05-16

Their study ("Endothelial progenitor cells stimulate neonatal pulmonary angiogenesis via foxf1-mediated BMP9/ACVRL1 signaling") was published in the journal Nature Communications .
Nature Communications: Novel mechanism of PD-L1 regulation by RNA-binding protein DENR

 Time of Update: 2022-05-16

, Nose and Throat Hospital jointly published a paper entitled DENR controls JAK2 translation to induce PD-L1 in Nature Communications. Expression for tumor immune evasion research paper, which revealed a new mechanism by which RNA-binding protein
protein synthesis journey

 Time of Update: 2022-05-16

This involves the formation of peptide bonds between amino acids that bind to transfer RNA (tRNA) molecules that slide in close proximity on the ribosome and elongate the peptide chain, followed by a conformational change to form the protein .
Oncogene: DCAF12 is a novel antagonist of anti-apoptotic protein IAPs

 Time of Update: 2022-05-14

. In normal cells, there is a good regulatory balance between pro-apoptotic proteins and anti-apoptotic proteins, and they work together to regulate apoptosis
in the reconstruction of protein dynamics regulation by artificial intelligence-assisted time-resolved cryo-EM

 Time of Update: 2022-05-13

revealed" in the Research Briefing column. In the article, the reviewers commented that "this work is a major study that finally solves the problem of USP14 activation
Blocking or deleting a protein could help prevent common oral cancer

 Time of Update: 2022-05-13

>But LSD1 isn't the only troublemaker in tumors: When it's upregulated, it disrupts a cellular communication process -- the Hippo signaling pathway -- yap -- which normally helps control organ growth and tissue regeneration

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