Chinese scholars have discovered the apoptosis mechanism of inflammatory macrophages
Time of Update: 2021-03-05
macrophage apoptosis, and found apoptosis mechanisms for macrophages in inflammatory states. The papers are published in internationally renowned journals . The team identified the metal ion transport protein SLC39A10 mediated macrophage
Cell Survival and Apoptosis Assays for E1B 19K and Bcl-2 Family Members
Time of Update: 2021-02-15
Apoptosis is regulated by a number of genes that promote or suppress cell death.
Cell Death Differ:PIWIL2 regulates the occurrence of autophagy and apoptosis of esophageal squamous cell cancer cells by interacting with IKK
Time of Update: 2021-02-01
As one of the most common malignant tumors in China, ESCC has a low five-year survival rate, which is also associated with the late diagnosis of the disease, frequent metastasis and the development of therapeutic resistance.
Using the Baculovirus/Insect Cell System to Study Apoptosis
Time of Update: 2021-01-25
Because of the importance of programmed cell death for the survival of the organism a tight regulation is exerted at various activation levels of the cell-death machinery.
Scientists have found that targeting TRADD restores cell stability and inhibits apoptosis
Time of Update: 2021-01-05
For example, it has previously been found that aging-induced freezing disorder (ALS), protein kinase RIPK1-mediated inflammation of small glial cells, and death of less dendritic glial cells are important causes of the disease (Xu, et al., 2018, Cell).
Blood: New CRBN E3 connective enzyme regulator CC-90009, targeted to promote leukemia stem cell apoptosis
Time of Update: 2020-12-24
many clinically effective drugs have been developed by re-using the CUL4-DDB1-CRBN-RBX1 (CRL4CRBN) E3 Ubigan connective enzyme complex with molecular gel degradation agents to eliminate pathogenic proteins.
Methods for the Study of NO-Induced Apoptosis in Cultured Cells
Time of Update: 2020-12-18
In 1972, Kerr et al. ( 1 ) described a mechanism of cell death that was morphologically distinct from necrosis and they coined the term “apoptosis” [derived from the Greekapo (from) andptosis (to fall
Cell Death Differ: Necrosis apoptosis is not necessary for the development of inflammatory or exudable colon cancer
Time of Update: 2020-12-15
the absence of MLKL or RIPK3 had no effect on the development of exudable colon cancer overall, these studies do not support the important role of necrosis apoptosis in gastrointestinal inflammation or cancer.
Oxidative Lipidomics of Apoptosis: Quantitative Assessment of Phospholipid Hydroperoxides in Cells and Tissues
Time of Update: 2020-12-06
The identification and quantification of oxidized phospholipids generated during apoptosis can be successfully achieved by oxidative lipidomics.
Quantitative assessment of lipid hydroperoxides is performed by fluorescence HPLC-based protocol.
Chinese scholars have found that reishic acid can induce the apoptosis of esophal scale cancer cells
Time of Update: 2020-12-04
Recently, huang Qing researcher team of Hefei Institute of Material Sciences recently made new discoveries in the pharmacological research of Reishi anti-cancer, reishi acid can induce apoptosis and autophagy cell death of esophageal scale cancer cells.
Detection of Apoptosis Using Cyclic Luciferase in Living Mammals
Time of Update: 2020-12-01
The caspase activities in living subjects and their regulation with small chemical compounds are of great interest for screening drug candidates or pathological agents.
Apoptosis detection: detection method of bio-chemical characteristics.
Time of Update: 2020-10-26
Add 50 to 100 μl TE buffer, plus 5 μl RNase, 37 degrees C water bath 30min.
Yassin Pharmaceutical Apoptosis Inhibitors were certified by 2 more FDA orphan drugs.
Time of Update: 2020-10-24
type, namely non-small cell lung cancer (NSCLC) and SCLC, of which about 13%-15% are classified as SCLC. SCLC is a rare and invasive malignant tumor with a low survival rate of 5 years3. treatment options are few, especially for patients
Two new drugs targeted at apoptosis have been designated by the FDA for orphan drugs.
Time of Update: 2020-10-19
, activating the anti-tumor activity of p53 by blocking the interaction between the MDM2-p53 protein and the protein (PPI). APG-115 is the first MDM2-P53 inhibitor to enter clinical practice in China and is currently being evaluated in several
Cancer Res: Apoptosis inhibitors may promote the tolerance of certain lymphomas to a variety of therapies.
Time of Update: 2020-10-14
by avoiding the immune supervision of radiotherapy, chemotherapy, or endogenes, apoptosis, also known as programmed cell death, an orderly and well-designed cell suicide process that is performed primarily by regulatory proteins to react to internal
J Cell Physiol: Histoprotein demethylase KDM7A is necessary for breast cancer stem cell maintenance and apoptosis suppression.
Time of Update: 2020-10-12
, the results show that KDM7A promotes the maintenance and apoptosis inhibition of cancer stem cells in breast cancer.
Apoptosis detection techniques and methods.
Time of Update: 2020-09-07
, and then through a simple color or light-emitting system for detection. because this is a living cell detection in the early stages of apoptosis (both suspended and wall cells apply), it can be combined with DNA dyes or other late detection
YAP is an important regulatory factor for the apoptosis and EMT degree mediated by TGF-beta1.
Time of Update: 2020-09-05
presents the latest research results on the interrelation and balance regulation of two distinct cell fates, with apoptosis caused by transformational growth factor (TGF)-beta1, and endocal-interstate transgeneration (EMT).
The study significance of ultra-low temperature preservation causing apoptosis.
Time of Update: 2020-08-25
The extensive and in-depth study of the two physiological phenomena of oxidative stress and apoptosis in ultra-low temperature preservation is not only of great theoretical significance to reveal the mechanism of ultra-low temperature preservation
Blood:JAK/STAT inhibition enhances the sensitivity of CD8 T cells to desermison-induced apoptosis.
Time of Update: 2020-08-24
recently, researchers found that cytokine-induced JAK/STAT signals mediated the resistance of T-cell acute lymphoblastic leukemia (T-ALL) cells to d'isemison, which RUX can effectively reverse.