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The latest paper by Zhu Di’s team at Fudan University: RORγt agonists enhance anti-PD-1 therapy

 Time of Update: 2022-05-15

On April 23, 2022, Researcher Zhu Di of Fudan University published a paper titled "RORγt agonist enhances anti-PD-1 therapy by promoting monocyte" in the Journal of Experimental & Clinical Cancer Research (IF=11.
Professor Chen Qijun's research group revealed that dihydroartemisinin regulates spleen immune cell heterogeneity through SOD3-JNK-AP-1 signaling pathway

 Time of Update: 2022-05-01

group from Shenyang Agricultural University published a research paper entitled "Dihydroartemisinin beneficially regulates splenic immune cell heterogeneity through the SOD3-JNK-AP-1 axis" in Science China Life Sciences, revealing that DHA regulates
First-line treatment of non-small cell lung cancer mRNA vaccine/PD-1 antibody combination is about to enter the clinic

 Time of Update: 2022-04-30

in combination with the PD-1 inhibitor Libtayo (cemiplimab) for the treatment of advanced stage Non-small cell lung cancer (NSCLC) patients . >BNT116 is a cancer vaccine
Behind the scenes of type 1 diabetes: immune T cells that won't be exhausted "Nature" paper recommended

 Time of Update: 2022-04-29

Authors: Stephen J. Turner & Nicole L. La Gruta The discovery that a specific subset of immune system T cells contributes to type 1 diabetes not only sheds new light on autoimmune
The target of liver cancer cell therapy from the world's first case of CAR-T cure for liver cancer (Part 1)

 Time of Update: 2022-04-27

Considering other forms similar to CAR-T, such as CAR-NK, TCR-T, this article will review the targets of adoptive cell therapy for the treatment of liver cancer in two parts .
; domestic PD-1 refreshes chemoimmune combined with first-line treatment of advanced lung squamous cell carcinoma OS records tumor intelligence

 Time of Update: 2022-04-27

interim analysis of KEYNOTE-716 evaluating pembrolizumab as adjuvant therapy in patients with completely resected high-risk stage II melanoma . Studies have shown that adjuvant
Science Advances: Implanting a "cell drug factory" in the body to remove cancer cells in 6 days, and clinical trials will be launched this year

 Time of Update: 2022-04-23

/> Unfortunately, many cancer patients experience severe side effects when administered in such high doses, resulting in multiple organ damage, which has also hindered widespread use of this treatment .
Front Oncol: Efficacy of low-dose nab-paclitaxel combined with PD-1 inhibitor (tislelizumab

 Time of Update: 2022-04-23

Median PFS was significantly longer in patients with EGFR/ALK wild-type non-squamous NSCLC (11. Median PFS was significantly longer in patients with EGFR/ALK wild-type non-squamous NSCLC (11.
Research progress on rapid detection methods of bovine milk somatic cells (1)

 Time of Update: 2022-03-14

Increased number of somatic cells in milk may also cause the pH, protein , lactose , lipase change indicators, and the like, so that the product quality is affected .
The third-generation EGFR inhibitor in the targeted therapy series for non-small cell lung cancer (NSCLC) (1)

 Time of Update: 2022-03-06

In the CTONG 0901 study, 256 patients with advanced non-small cell lung cancer with EGFR exon 19 or 21 mutations were randomized to receive erlotinib or gefitinib and compared PFS and OS .
Russian grain exports to fall by nearly 50% from January 1 to February 6, 2022

 Time of Update: 2022-03-03

During the same period , the export value of cereals reached US$508 million, a year-on-year decrease of 49%, while the export of oil and fat products reached US$529 million, an increase of 15% year-on-year.
Mechanism of Infiltration Barrier in Transforming "Cold Tumor" into "Hot Tumor" by Improving T Cell Infiltration (1)

 Time of Update: 2022-02-20

This result suggests that activation of Wnt/β-catenin signaling and deficient BATF3 DCs mediate T cell rejection and tumor cell escape from the immune system .
Kazakhstan's daily oil and condensate production fell 6% month-on-month from January 1-9

 Time of Update: 2022-01-25

Foreign news on January 10, according to two industry sources, Kazakhstan's daily oil and gas condensate production in early January fell by 6% from December last year, due to large-scale anti-government protests in the country .
6 sheets to master the 2022 v2 gastric cancer treatment plan to understand the NCCN guidelines in 1 minute

 Time of Update: 2022-01-25

*Only for medical professionals to read and reference Come forward and learn!
J Immunother Cancer: The efficacy of PD-1 inhibitor combined with chemotherapy in neoadjuvant

 Time of Update: 2022-01-23

Therefore, a team from the First Affiliated Hospital of Sun Yat-Sen University conducted a related study to evaluate the efficacy of PD-1 inhibitor combined with chemotherapy in neoadjuvant therapy for patients with resectable esophageal squamous cell carcinoma .
Junshi Bio's PD-1 inhibitor first-line treatment of non-small cell lung cancer is accepted by CDE

 Time of Update: 2022-01-11

accepted its self-developed anti-PD-1 monoclonal antibody drug teriprizumab combined with standard first-line chemotherapy for untreated, driver genes A new indication for the marketing of negative advanced non-small cell lung cancer (NSCLC
KHYG-1 NK cells expressing CD38-specific chimeric antigen receptors in Myeloma New Horizons

 Time of Update: 2022-01-10

In June 2021, "HemaSphere" published a study on the proof of concept of KHYG-1 NK cells expressing CD38-specific chimeric antigen receptors for multiple myeloma (MM) "off-the-shelf" therapy
In December, 6 Class 1 new drugs and 2 first copy approvals were approved, and these 6 blockbuster varieties declared new indications

 Time of Update: 2022-01-09

Summary>Summary In December, CDE undertook 1,366 drug registration applications>
Immunotherapy for small cell lung cancer: the PK of PD-1 and PD-L1

 Time of Update: 2022-01-09

, and they were divided into a chemotherapy-only group and a chemotherapy combined with ICIs group (atilizumab, 1200 mg, once every 3 weeks) according to a ratio of 1:1 . The results showed
STTT: The domestic multi-center study ORIENT-4 confirmed that the PD-1 inhibitor sintilimab

 Time of Update: 2022-01-08

jointly launched a multi-center, single-arm phase II study ORIENT-4 (NCT03228836) to evaluate the PD-1 inhibitor sintilimab (sintilimab) in the treatment of relapsed/refractory extranodal NK/T cells Efficacy and safety of patients with lymphoma (r/r

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