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Express plans to spend about $1.9 billion to harvest Phase 3 clinical JAK inhibitors, GlaxoSmithKline expands hematology pipeline

 Time of Update: 2022-06-17

Sierra Oncology's innovative JAK inhibitor momelotinib recently met all primary and key secondary endpoints in a pivotal Phase 3 clinical trial in patients with myelofibrosis and is expected to submit a regulatory filing in the U.
Express 75% of patients maintained complete remission after one year, with positive Phase 2

 Time of Update: 2022-06-17

▎WuXi AppTec Content Team Editor Today, CG Oncology announced that the company's oncolytic virus therapy CG0070, in combination with Merck's anti-PD-1 antibody Keytruda, has been approved in a Phase 2 clinical trial for the treatment of non-muscle invasive bladder cancer.
Express AI helps develop innovative protein degraders, and Boehringer Ingelheim reaches R&D cooperation

 Time of Update: 2022-06-09

References:References: [1] VantAI Forms Research Collaboration with Boehringer Ingelheim to Identify Novel Protein Degraders. html[1] VantAI Forms Research Collaboration with Boehringer Ingelheim to Identify Novel Protein Degraders.
Express T cell therapy has been recognized by the FDA as an advanced therapy for regenerative

 Time of Update: 2022-06-06

▎WuXi AppTec Content Team Editor Recently, AlloVir announced that its multi-virus-specific T cell therapy posoleucel has received FDA Regenerative Medicine Advanced Therapy Designation (RMAT) for high-risk adults after allogeneic hematopoietic cell transplantation (allo-HCT).
CTD Journal Inhaled ibuprofen salts have potential to reverse pulmonary vascular paralysis in patients with COVID-19 pneumonia

 Time of Update: 2022-06-05

Recent studies have shown that an inhaled, non-hormonal anti-inflammatory drug, sodium ibuprofen (NaIHS) dissolved in hypertonic sodium salts, can relieve hypoxia symptoms in patients with moderate to severe COVID-19 pneumonia .
SCM2022 Conference Intelligence Express Lupus Nephritis New Dawn - VOCLOSPORIN?

 Time of Update: 2022-06-05

For patients on Voclosporin, regardless of whether complete renal remission was achieved at week 52, anti-dsDNA levels were decreased and C3 complement levels were increased .
Express first-line treatment of liver cancer, anti-CTLA-4/PD-L1 antibody combination entered priority review

 Time of Update: 2022-06-04

It was used in combination with Imfinzi and chemotherapy to significantly improve patients' overall survival in a Phase 3 clinical trial in first-line treatment of stage IV non-small cell lung cancer .
Is Weilaixianfeng PD-L1 expression an effective predictor of immunotherapy?

 Time of Update: 2022-06-03

Question 1: Your team published "Appropriate PD-L1 Cutoff Value for Gastric Cancer Immunotherapy: A Systematic Review and Meta-Analysis1" in Front Oncol 2021.
Express first!

 Time of Update: 2022-06-01

▎WuXi AppTec content team editor Recently, the FDA's official website shows that the FDA has approved the oral antifungal drug Vivjoa (oteseconazole) developed by Mycovia Pharmaceuticals for the reduction of recurrent vulvovaginal Candida in women of no reproductive potential.
Express $25 million to help develop a new generation of synthetic lethal therapy, Pfizer reaches R&D cooperation

 Time of Update: 2022-05-31

Pfizer and Zentalis have entered into an agreement to collaborate to advance the clinical development of selective Wee1 inhibitors, an innovative therapy that uses the principle of synthetic lethality to kill cancer cells .
Express AstraZeneca/Daiichi Sankyo's blockbuster ADC won the 5th breakthrough therapy designation for the treatment of HER2 low-expressing breast cancer

 Time of Update: 2022-05-31

” Reference: [1] ENHERTU® Granted Breakthrough Therapy Designation in US for Patients with HER2 Low Metastatic Breast Cancer.
Express first-line treatment of esophageal cancer, BeiGene/Novartis PD-1 antibody combination

 Time of Update: 2022-05-31

treatment of advanced stage or met the primary endpoint in a phase 3 clinical trial in patients with metastatic esophageal squamous cell carcinoma (ESCC) . An interim analysis
Express FDA release, Pfizer DMD gene therapy phase 3 clinical trial is about to restart

 Time of Update: 2022-05-30

S. Food and Drug Administration (FDA) has notified the company to allow its Phase 3 clinical trial of fordadistrogene movaparvovec, a gene therapy for Duchenne muscular dystrophy (DMD), to continue .
Express Oral Delivery of Biologics, Positive Phase 2 Clinical Results of Innovative Cytokine Therapy

 Time of Update: 2022-05-29

Pouchitis. Retrieved April 25, 2022 , from https://ir. appliedmt. com/news-releases/news-release-details/applied-molecular-transport-announces-positive-top-line-phase-2 Advances in Biomedical Health Research
Express FDA releases, Phase 3 clinical trial of oral microbiome therapy is about to restart

 Time of Update: 2022-05-29

S. Food and Drug Administration (FDA) has allowed its clinical trial of CP101, its main oral microbiome therapy, to continue for the prevention of recurrent Clostridium difficile (C.
Express delivery enhances the durability of therapy, and differentiated CAR-T therapy is recognized by the FDA as an advanced therapy for regenerative medicine

 Time of Update: 2022-05-28

FDA Grants Regenerative Medicine Advanced Therapy (RMAT) designation to Autolus' CAR T cell therapy, obe-cel, for the treatment of adult B-ALL.
The symptoms of nearly half of the express patients improved by at least 40%, and AbbVie's JAK inhibitor was approved by the FDA

 Time of Update: 2022-05-28

S. FDA approved the expanded indication of its JAK inhibitor Rinvoq (upadacitinib, upadacitinib) for the treatment of active ankylosing spondylitis (ankylosing spondylitis, AS) adult patients .
Express blood test for cancer detection, early colorectal cancer screening test launched, with a sensitivity of 91%

 Time of Update: 2022-05-28

▎WuXi AppTec Content Team Editors Today, Guardant Health announced the launch of the Shield blood test to detect early signs of colorectal cancer in adults at average risk .
Express Detects Alzheimer's-Related Amyloid Deposits Early, FDA Approves First In Vitro Diagnostic Test Today

 Time of Update: 2022-05-27

▎WuXi AppTec Content Team Editor The U. S. Food and Drug Administration announced today that it has approved the first in vitro diagnostic test for the early detection of amyloid plaques
Express to Eradicate Helicobacter pylori Infection, FDA Approves Innovative Combination Therapy

 Time of Update: 2022-05-27

-life and longer duration of action, vonoprazine is regarded as a potent long-acting proton pump inhibitor (PPI) . The FDA has previously granted Qualified Infectious Disease

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