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imipramine mechanism of action

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"Nature" heavy: Chinese scientists crack the mechanism of action of metformin

 Time of Update: 2022-05-23

▲Metformin binds to PEN2 to activate AMPK (Image source: Reference [1])Next, the research team revealed the pathway by which metformin works based on this newly discovered target .
Nature: Widespread brain receptor hides surprising mechanism of action

 Time of Update: 2022-05-17

Rather than a direct step-by-step transition, Sobolevsky and his colleagues found that the glutamate molecule must first bind to one of two specific subunits of the receptor before it can bind to the other two .
Cell: Mechanism of action of GPCRs

 Time of Update: 2022-05-12

"In our study, we used an approach that allowed us to explore, in unprecedented detail, how drug-stimulated GPCRs activate β-arrestin, a protein that both terminates some signals and mediates others ” said Wesley B.
JCI: Shen Zhanlong's team from Peking University People's Hospital reveals the mechanism of action

 Time of Update: 2022-05-09

screen patients who benefit from PD-L1 inhibitor therapy, from single-cell precision Revealed a new mechanism of immunotherapy targeting TAM cells and dendritic cells (DC), and discovered a new mechanism of ubiquitination regulation with better
spike protein and its complex structure with receptors and antiviral antibodies, and revealed the mechanism of action

 Time of Update: 2022-03-08

to the spike protein of the Omicron variant was 4 times that of the wild type, showing the potential to inhibit the Omicron variant . From the resolved complex structure, the research team found
Tsinghua University School of Pharmacy Tang Yefeng's group and their collaborators discovered anti-mycobacterial compounds with new mechanism of action

 Time of Update: 2022-03-08

bovis BCG raised against the compound Table 4 Mutations in the IND resistant mutants of M.
Significant improvement in dry eye symptoms New mechanism of action eye drops Phase 2 clinical results are positive

 Time of Update: 2022-02-23

Recently, Aldeyra Therapeutics announced positive top-line data from a Phase 2 clinical trial of its investigational therapy reproxalap eye drops in patients with dry eye disease .
The unknown mechanism of T cell action before the publication of Science sub-journals: signaling pathways necessary for survival

 Time of Update: 2022-01-09

survival independently of TCR and IL-7 signaling . Science Signaling , 2021; 14 (714) DOI: 10. 1126/scisignal. abj0057> >
Deqi Pharmaceutical's first product, Civio®, was approved for the market, and the new mechanism of action has broad application prospects｜Press release

 Time of Update: 2021-12-30

Stock Exchange stock code: 6996. HK) announced today that the National Medical Products Administration (NMPA) has approved The new drug application (NDA) of Civio® (Celinisol, ATG-010), through the combination with dexamethasone
Innovative Mechanism of Action Novartis Leukemia Therapy Receives FDA Approval

 Time of Update: 2021-12-03

Retrieved October 29, 2021, from https:// 29/2323914/0/en/FDA-approves-Novartis-Scemblix-asciminib-with-novel-mechanism-of-action-for-the-treatment-of-chronic-myeloid-leukemia.
Express Innovative Mechanism of Action, Novartis Leukemia Therapy Receives FDA Approval Today

 Time of Update: 2021-11-15

▎The content team editor of WuXi AppTec today, Novartis announced that the US FDA has approved Scemblix (asciminib) for the treatment of two different indications of chronic myeloid leukemia (CML) .
sterol relieves atherosclerosis and its potential mechanism of action

 Time of Update: 2021-11-14

Sargassum fusiforme Modulates Cholesterol Metabolism and Alleviates Atherosclerosis in ApoE-Deficient Mice" by Ying Hao Research Group of the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences. Research results
[Cancer Cell] Chinese scholars reveal the mechanism of action of Anti-PD-L1 immunotherapy combined with chemotherapy in triple-negative breast cancer

 Time of Update: 2021-11-14

groups of pro-inflammatory macrophages with high expression of CXCL9 and CXCL10, and these two groups were pro-inflammatory There is a significant positive correlation between sex macrophages and CXCL13+ T cells (Figure 3)
Cancer Cell Chinese scholars reveal the mechanism of action of Anti-PD-L1 immunotherapy combined with chemotherapy in triple-negative breast cancer

 Time of Update: 2021-11-11

under different treatment options> >In addition, the researchers found that the tumor microenvironment of the responding patients was enriched in two groups of pro-inflammatory macrophages with high
"Nature" study reveals the mechanism of glycoprotein hormone action

 Time of Update: 2021-11-05

Recently, researcher Xu Huaqiang, researcher Jiang Yi, and researcher Zhang Yan of Zhejiang University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, jointly published research papers in the top academic journal "Nature
Cancer Cell: Zhang Zemin's team and others reveal the mechanism of action of anti-PD-L1

 Time of Update: 2021-11-02

is ineffective against hormone therapy and targeted therapy. At present, traditional chemotherapy is the main treatment method, but the effect is not satisfactory . >Although cancer immunotherapy has entered a period
Science Immunology challenges the original theory: the mechanism of action of ineffective drugs for psoriasis

 Time of Update: 2021-11-01

In fact, as the researchers discovered, the recognition of interleukin-12 by these skin cells is responsible for the protection of the messenger .
Shandong University's latest article: Mechanism of action of lncRNA THAP7-AS1 that promotes gastric cancer metastasis

 Time of Update: 2021-11-01

Recently, the team of Professor Gao Peng of Shandong University School of Basic Medicine published in Cell Death & Differentiation (Chinese Academy of Sciences, IF: 15.
Cancer Cell Liu Zhihua/Zhang Zemin/Ma Fei/Xu Binghe collaborated to reveal the mechanism of action

 Time of Update: 2021-10-21

treatment options on the TNBC tumor microenvironment. In summary, this study revealed the molecular mechanism of TNBC patients' sensitivity and resistance to anti-PD-L1 immunotherapy, and identified key immune components and their suppression
Cancer Cell Zhang Zemin's research group and collaborators reveal the mechanism of action of anti

 Time of Update: 2021-10-20

/>. > >　　In addition, the researchers found that the tumor microenvironment of the responding patients was enriched in two groups of pro-inflammatory macrophages with high expression of CXCL9

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