Acute T-lymphoblastic leukemia (T-ALL) is an invasive form of leukemia, most commonly found in children, characterized by very little stained weight row at the time of diagnosis and 10-20 individual cell mutations in the protein coding area.
De-ubibinase axin-3 regulates the pattern of DNA damage response to the important kinase Chk1.
Time of Update: 2020-09-13
, the DNA damage response. DNA damage response is a complex signal transductive network system that senses DNA damage and transmits signals, which in turn causes a series of responses, such as cell cycle test points, DNA repair, transcription changes
TET3-mediated de-methylation plays an important role in THER-dependent DNA damage repair.
Time of Update: 2020-09-09
On March 21, EMBO Reports published a research paper by Li Jiali of the Kunming Institute of Zoology of the Chinese Academy of Sciences, which revealed the regulatory role between DNA de-methylation and DNA damage repair.
Nature Genetics: Is the weapon of cancer "evolution"? Scientists have found that cancer genes amplification in chromosome DNA can promote tumor development.
Time of Update: 2020-09-05
cells more adaptable to the environment and respond to changes in the tumor's internal environment. previous studies have speculated that cancer-inducing is essentially an "evolutionary" manifestation. ecDNA will change the expression
Long non-coding RNA SLERT plays an important role in cell nucleation function and RNA polymerase I (Pol I) transcription.
Time of Update: 2020-09-04
of Sciences: SLERT regulations DDX21-rings with Pol I transcription, which reveals the important role of long non-coding RNA SLERT in cellular kernel function and RNA polymerase I (Pol I) transcription. human cells contain about 400 copies
Chromosin remodeling factor PKL plays an important regulatory role in the process of RNA-mediated DNA methylation.
Time of Update: 2020-08-31
the important regulatory role of chromosin remodeling factor PKL in the process of RNA-mediated DNA methylation. In plants, RNA-mediated DNA methylation (RdDM) is an important mechanism for establishing new DNA methylation styles
The RNA anti-chain exchange guided by the congener recombinant protein Rad52 repairs the damaged DNA.
Time of Update: 2020-08-31
process of recombination, which exchanges genetic information between two DNA molecules, plays a crucial role in DNA repair, but specific genetic mutations can disrupt gene stability.
Mangrove Bio-Resource Survey and Important Species DNA Barcode Library Construction Project Started.
Time of Update: 2020-08-29
project will complete the research on seven subjects, such as the survey of mangrove biological resources in Fujian, Zhejiang Province, the collection of DNA barcode data of mangrove biological resources, and the construction of mangrove ecosystem resource database.
Revealthe the genetic evolution of RNA viruses.
Time of Update: 2020-08-10
Today, the world's serious infectious diseases, such as Ebola virus disease, AIDS, etc., mainly caused by RNA virus. team led by Zhang Yongzhen, a researcher at the CDC Infectious Diseases Institute of China and an adjunct professor
J Hematol Oncol: University participants have discovered important regulatory roles in acute myeloid leukemia with new small molecule RNA.
Time of Update: 2020-07-29
Recently, !---- professor Zeng Hui, director of the Department of Hematology, a clinical first-level leader at the First Hospital affiliated with Jinan University, has made important progress in the field of leukemia resistance, publishing
Sci Signaling . . . The results of the Guo Fei team reveal important molecular mechanisms that regulate cGAS-induced DNA.
Time of Update: 2020-07-23
Responsible . . . Enzyme-U.S. DNA identifies receptor ring bird glycolic acid-adenosine synthase (cGAMP) synthase, cGAS) to identify exogenous DNA as well as RNA: DNA hybrid chain, thereby catalyzing the production of second messenger ring-bird
DNA base editor may induce a large number of off-target RNA mutations
Time of Update: 2020-06-09
Source: CC0 Public Domain DNA base editing methods can directly correct dot mutations in genomic DNA without producing any double-stranded fractures (DSBs, double-breaks), but the potential off-target effect often limits the application