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intrathecal chemotherapy methotrexate side effects

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JAMA: The effect of celecoxib combined with FOLFOX standard adjuvant chemotherapy on the disease-free survival rate of colon cancer patients

 Time of Update: 2021-04-17

Recently, researchers investigated the effect of adding celecoxib to the adjuvant chemotherapy regimen of fluorouracil, calcium leucovorin and oxaliplatin (FOLFOX) on the disease-free survival rate of patients with stage III colon cancer .
JCO: The effect of adjuvant chemotherapy on the quality of life of elderly patients with HER2-positive breast cancer

 Time of Update: 2021-04-17

to trastuzumab (T) group and trastuzumab combined chemotherapy group (T+C). Using the Comprehensive Cancer Therapy Functional Assessment Scale (FACT-G), Philadelphia Geriatric Center Morale Scale, Hospital Anxiety and Depression
JAMA Oncol: Tislelizumab combined with chemotherapy as a first-line treatment for advanced squamous non-small cell lung cancer has a significant effect

 Time of Update: 2021-04-16

In conclusion, in this phase 3 randomized clinical trial, regardless of the expression of PD-L1, for patients with advanced sq NSCLC, the addition of Tislelizumab and IRC to chemotherapy significantly prolonged PFS, higher ORR, and better safety/resistance.
Nature: It is so difficult to investigate rare side effects of COVID vaccine

 Time of Update: 2021-04-16

Hilda Bastian said that because hundreds of millions of people are currently vaccinated against COVID-19, even very rare events-such as severe allergic reactions or blood clots-will start to appear in safety reports.
Lancet Oncol: Active symptom control combined with FOLFOX chemotherapy can effectively prolong

 Time of Update: 2021-04-14

Recently, The Lancet Oncology published a study in which patients with advanced biliary
JCO: Lower dose, side effects halved, just as effective!

 Time of Update: 2021-03-27

At the same time, tamoxifen is also approved for the adjuvant treatment of breast cancer, which can significantly reduce the risk of postoperative recurrence.
Express | Aiming to solve the problem of side effects of IL-2 immunotherapy, Xinrui completes US$55 million in Series A financing

 Time of Update: 2021-03-27

The company's main product candidate, AB248, is a fusion protein that selectively activates the IL-2 receptor signaling pathway in CD8-positive T cells.
You never expected these "weird" effects of methotrexate!

 Time of Update: 2021-03-25

effect. It can inhibit dihydrofolate reductase to prevent the body from synthesizing purine nucleotides, thereby inhibiting the synthesis and growth of immune cells.
CAR-T-related encephalopathy syndrome of CAR-T cell side effects | CAR-T cell treatment of NHL side effects clinical management expert consensus

 Time of Update: 2021-03-24

Expert consensus on clinical management of the toxic and side effects of CAR T cell treatment of NHL[J].
CAR-T cytotoxicity and side effects CRS | CAR-T cell treatment of NHL toxic and side effects clinical management expert consensus

 Time of Update: 2021-03-24

. The Biotherapeutics Committee of the Chinese Research Hospital Association organized experts to refer to and learn from the existing CAR-T
CAR-T cell side effects of infection | CAR-T cell treatment of NHL side effects clinical management expert consensus

 Time of Update: 2021-03-23

>In this issue, the editor summarizes the infection part as follows for the reference of readers.
Zhang Zhi et al. reveal the neural mechanism of the side effects of the anti-breast cancer drug tamoxifen

 Time of Update: 2021-03-22

Through tissue specificity Gene knockout and single-cell sequencing revealed that the estrogen receptor alpha (ERα) located in the hypothalamus is a key target that mediates tamoxifen's metabolic side effects such as hot flashes.

Eur Radiol: Use MRI to evaluate the chemotherapy effect of bone tumors and evaluate survival

 Time of Update: 2021-03-20

/10. 1007/s00330-020-07338-y">10. 1007/s00330-020-07338-y>

Breast: Olanzapine can effectively prevent nausea and vomiting caused by chemotherapy in Chinese breast cancer patients

 Time of Update: 2021-03-20

gov/31978815/" target="_blank" rel="noopener">A randomized study of olanzapine-containing versus standard antiemetic regimens for the prevention of chemotherapy-induced nausea and vomiting in Chinese breast cancer patients .

Reduce the side effects of cell therapy! Pfizer's research team uses this small molecule as a "switch"

 Time of Update: 2021-03-08

team from Pfizer has designed a single-module CAR that can be activated under certain conditions, with tumor antigens that are directly regulated by FDA-approved small molecule drugs, ultimately regulating CAR-T cell activity.

Sci Adv: What's new! The metabolic defects of the Parkinson's disease drug L-Doba are directly related to severe side effects in the patient's body!

 Time of Update: 2021-03-06

January 11, 2021 // -- So far, researchers don't know why the drug levodopa (L-Dopa), which can reduce motor symptoms in people with Parkinson's disease, is declining after several years of use; One of the most common side effects is that patients

The study revealed the molecular mechanism of microorganisms affecting the effects

 Time of Update: 2021-03-02

the relationship between intestinal bacteria disorder and the development of colorectal cancer is attracting more and more attention, however, whether the change of enterobacteria affects the effect of chemotherapy for colorectal cancer is not clear.

NEJM: "Wrong" statins, common myalgia problems are not pharmacological side effects?

 Time of Update: 2021-02-24

patients taking statins and placebos experienced similar adverse reactions, according to a clinical trial recently published at the American Heart Association's (AHA) 2020 scientific meeting.

Beware of gene therapy side effects "angel syndrome" clinical trials have been called off

 Time of Update: 2021-02-24

experienced the same adverse reactions after receiving the highest dose. these symptoms appear one to four weeks after the participants were last given the drug. two of the patients had lower limbs that were unable to walk or carry weight

Studies warn that some drugs may have side effects on the lungs

 Time of Update: 2021-02-06

Some drugs used to treat a variety of diseases, including cancer, may have side effects on the lungs, and the effects are greater than previously thought, according to a new study published by the University of Manchester.

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