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Neuron Liu Kai's team found that activating type II interferon and cGAS-STING signaling pathways in the nervous system can promote axon regeneration
Time of Update: 2023-01-06
On November 11, 2022, Liu Kai's research group of the Hong Kong University of Science and Technology published a long article "Driving Axon Regeneration by Orchestrating Neuronal and Non-neuronal Innate Immune Responses via the" in Neuron IFNγ-cGAS-STING Axis, found that by knocking out PTPN2 and adding type II interferon stimulated genes (ISGs) in neurons including the cGAS-STING pathway, it was possible to activate interferon stimulated genes (ISGs).
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Neuron Liu Kai's team found that activating type II interferon and cGAS-STING signaling pathways in the nervous system can promote axon regeneration
Time of Update: 2023-01-06
On November 11, 2022, Liu Kai's research group of the Hong Kong University of Science and Technology published a long article "Driving Axon Regeneration by Orchestrating Neuronal and Non-neuronal Innate Immune Responses via the" in Neuron IFNγ-cGAS-STING Axis, found that by knocking out PTPN2 and adding type II interferon stimulated genes (ISGs) in neurons including the cGAS-STING pathway, it was possible to activate interferon stimulated genes (ISGs).
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Lancet: Effects of physical activity and sedentary behavior on the development of type 2 diabetes from childhood to late adolescence
Time of Update: 2023-01-04
The investigators used data from the Quebec Adolescent Obesity and Lifestyle Survey (QUALITY) cohort of children of Western European descent (white, non-Hispanic or ethnic) parents with a history of obesity (defined as a BMI of 30 kg/m2 or more, or waist circumference of more than 102 cm in men and 88 cm in women), assessed at age 8 to 10 years (baseline), and followed at 10–12 years (first follow-up cycle) and 15–17 years (second follow-up cycle).
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Research Frontiers The number of active surveillance biopsies in patients with this type of PCa can be reduced...
Time of Update: 2022-10-25
Fig. 2 Comparison of the proportion of increased GG grading between the two groupsMultivariate analysis showed a significantly lower risk of switching to aggressive treatment in the biopsy-negative group compared with the initial biopsy-positive result group (HR: 0.
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3 types of leisure activities that can reduce your risk of developing dementia
Time of Update: 2022-09-14
The researchers found that people who participated in these activities had a 7 percent lower risk of developing dementia.
The researchers found that people who participated in these activities had a 7 percent lower risk of developing dementia.
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Actively promote the "integration of sports and medicine and non-medical health intervention
Time of Update: 2022-09-07
Guideline name: Expert consensus on the mitigation of type 2 diabetes with exercise combined with nutritionEnglish title:Publisher: Guangzhou Institute of Applied Science and TechnologyRelease date: 2
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J Autoimmunity: A panel of type II interferon-regulated genes is associated with disease activity in patients with systemic lupus erythematosus
Time of Update: 2022-08-19
Objective: Upregulation of interferon-regulated genes (IRGs) in peripheral blood, expressed as an interferon (IFN) signature, has been used as an indirect measure of IFN pathway activation in patients with systemic lupus erythematosus (SLE) .
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Diabetes Care: Changes in physical activity and dementia risk in patients with new-onset type 2 diabetes
Time of Update: 2022-04-20
Blood vesselCONCLUSIONS: Regular PA was independently associated with reduced risk of all-cause dementia, AD, and VaD in patients with new-onset type 2 diabetes .
Regular PA was independently associated with reduced risk of all-cause dementia, AD, and VaD in patients with new-onset type 2 diabetes .
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ARD: A phase II randomized trial of the type I interferon inhibitor anivolumab in patients with active lupus nephritis
Time of Update: 2022-04-16
Conclusions: Although the primary endpoint was not met, in patients with active lupus nephritis, anifrugumab IR improved endpoint values including complete renal response at 52 weeks compared with placebo .
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: increased neuronal excitability mediated by type 2 nilanine receptor activity
Time of Update: 2022-01-25
Preliminary work in the laboratory of Professor Wayne Chen, University of Calgary, Canada, showed that shortening the open time of RyR2 can prevent and treat AD-related neuronal damage and cognitive decline in AD mouse models (5xFAD+/-).
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ligands to regulate the activity of Ɣaminobutyric acid type B receptors
Time of Update: 2021-12-28
On December 6, the internationally renowned journal eLife published an online publication titled "Allosteric ligands control the activation of a class C GPCR heterodimer by acting at the transmembrane interface" by Professor Liu Jianfeng’s team from the School of Life Science and Technology, Huazhong University of Science and Technology.
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Diabetologia: Dapagliflozin reduces the cardiovascular risk of type 2 diabetes by reducing thrombin production and platelet activation
Time of Update: 2021-11-12
Scale bar represents 100μmFigure 2 Dapagliflozin can reduce atherosclerotic plaque burden, circulating platelet-leukocyte aggregation and macrophage infiltration in L dlr −/− mice .
Male L dlr −/− mice received supplemental DD without (control) or with dapagliflozin (5 mg/kg body weight/day) for 25 weeks, and then analyzed the burden of atherosclerotic plaque and aorta Immune cell infiltration .
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JAHA: Type 2 diabetic patients with and without heart failure respond differently to dapagliflozin muscle sympathetic nerve activity
Time of Update: 2021-11-11
Dapagliflozin can significantly reduce MSNA levels in patients with type 2 diabetes, regardless of its blood sugar lowering effect .
Different Responses of Muscle Sympathetic Nerve Activity to Dapagliflozin Between Patients With Type 2 Diabetes With and Without Heart Failure .
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Qingdao Energy Institute has developed a new type of lithium-sulfur (selenium) battery system with double carbon and double active materials
Time of Update: 2021-09-13
However, the inherent shortcomings of lithium-sulfur batteries hinder its continued promotion and application: due to the low conductivity of elemental sulfur and polysulfur compounds (Li 2 S/Li 2 S 2 ), which is a reduction product , the active material in lithium-sulfur batteries is utilized Low rate and poor rate performance; the soluble polysulfur compounds produced during the charge and discharge process cause the "shuttle effect" to appear and reduce the cycle life of the battery .
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Mitsubishi Chemical is actively expanding its epoxy resin business: creating new demand with low-chlorine type and thin-film products
Time of Update: 2021-08-13
Mitsubishi hopes to develop new markets for its own products in addition to its existing supply fields such as coatings, adhesives, and semiconductors, so as to achieve continuous growth in the epoxy resin business.