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Nat Genet Zhang Zhao's group reveals the new role of reversal colons in activating the innate
Time of Update: 2023-01-01
Reverse locons are present in almost all eukaryotes and are extremely abundant in the genome. In humans, reversers make up up to 38% of the genome. After the activation of the reverse locon, the mRNA,
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H2S cycle-activated self-assembled nanoprobes for synergistic enhanced colon cancer-specific treatment
Time of Update: 2022-10-20
Abstract: Zeng Songjun's research group at the School of Physics and Electronic Science, Hunan Normal University has designed a novel endogenous H2S-triggered cobalt-doped POM-Co nanoprobe, which can achieve cyclic self-aggregation, controllable biodegradation and sustainable consumption ofH2S/GSH in response to H2S, which can be successfully used in synergistic enhanced tumor-specific photothermal and chemokinetic combination therapy 。Keywords: H2Scyclically activated nanomaterials, self-assembled nanoprobes, controlled biodegradation, precise/sustainable cancer treatment.
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syndrome diarrhea is related to colonic afferent nerve activation and has nothing to do with psychological scores
Time of Update: 2021-03-17
In addition, the pain severity score of individual IBS-D patients was significantly correlated with the stimulation of colonic afferent activation mediated by the biopsy supernatant (r = 0.
aspx" target="_blank" rel="noopener">Pain Severity Correlates With Biopsy-Mediated Colonic Afferent Activation But Not Psychological Scores in Patients With IBS-D.
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First discovery: the active microbiome has been colonized in the intestine of sheep fetus
Time of Update: 2021-03-17
Photo courtesy of Feed Institute of Chinese Academy of Agricultural Sciences Recently, the ruminant feed innovation team of the Feed Research Institute of the Chinese Academy of Agricultural Sciences revealed for the first time that there are active gut microbes before the birth of sheep fetuses, and determined the composition of the microbes and their active metabolites.
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Br J Cancer: The medicinal level IgG weakens the anti-cancer activity of Osaliplat against colon cancer cells
Time of Update: 2021-02-24
medicinal level IgG reduced Osali platinum-induced cell death by evaluating the combination of medicinal levels IgG (such as PRIVIGEN®IgG and Tonglu®IgG) with chemotherapy, the researchers did not directly observe any significant effect of IgG on tumor cell viability.
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Dig Dis Sci: Vitamin D deficiency leads to the activation of the colon's local renin-angionein system and exacerbates colon inflammation
Time of Update: 2021-01-22
, the study aims to explore whether vitamin D inhibits local colon RAS activation to reduce inflammation of the colon mucous membranes in mouse models of colitis.
this study confirms that vitamin D deficiency can lead to excessive activeness of local RAS in the colon and promote colon inflammation.
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Study finds salicin show anti-colon cancer activity
Time of Update: 2020-06-08
Today's rapid development of malignant tumors, colon cancer incidence rate increased year by year, increasing the social and economic burden, is a serious threat to human health Treatment of malignant