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BRAIN: Plasma biomarkers for diagnosis and prediction of Alzheimer's disease
Time of Update: 2022-05-23
The findings suggest that currently available plasma biomarkers reflect different aspects of Alzheimer's disease, some of which are associated with aging as well as disease-specific features, while others are related to disease progression mechanisms.
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Alzheimer & Dementia: These plasma proteins are linked to cognitive decline and long-term risk of dementia
Time of Update: 2022-05-23
To this end, experts from the Department of Epidemiology and Public Health at UCL, UK, examined the association between 4,953 plasma proteins and the risk of cognitive decline and dementia in two cohort studies followed for 20 years.
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Grid cell networks are impaired in a mouse model of early Alzheimer's disease
Time of Update: 2022-05-23
In a J20 transgenic mouse model of familial AD, coding impairment of the MEC grid cell network that overexpresses aβ in the hippocampus and entorhinal cortex .
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Alzheimer&Dementia: There is a significant gender difference in the prevalence of dementia, which is mainly related to these factors!
Time of Update: 2022-05-23
Increases in life expectancy around the world suggest that the incidence of Alzheimer's disease and related dementia (ADRD) will increase dramatically to more than 140 million by 2050 .
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Alzheimer&Dementia: Associations between vascular risk factors, neuroimaging biomarkers and the development of dementia
Time of Update: 2022-05-23
RESULTS : African Americans exhibited baseline cardiovascular risk factors, incidence of aging and dementia (CAIDE), Framingham Stroke Risk Profile (FSRP), and atherosclerotic cardiovascular disease risk compared with whites Estimated (ASCVD) score was higher .
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Alzheimer&Dementia: Daytime Sleepiness Predisposes to Alzheimer's?
Time of Update: 2022-05-23
with subjects who slept < 1 hour; Subjects with ≥1 sleep duration had a 40% higher risk of AD . >Among them, subjects who slept ≥ 1 hour per day had
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Study reveals molecular mechanism underlying altered gene expression in the brains of Alzheimer's patients
Time of Update: 2022-05-22
Now, in a study titled "Multi-transcriptomic analysis points to early organelle dysfunction in human astrocytes in Alzheimer's disease" published in the international journal Neurobiology of Disease, scientists from Spain analyzed data from nearly 800 deceased individuals.
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Nat Commun: Scientists discover potential therapeutic target for Alzheimer's disease!
Time of Update: 2022-05-22
, tau hyperphosphorylation, and neuronal loss remained unchanged . Administration of SCDi in 3xTg mice had broad effects on hippocampal synapse-related gene expression and resulted in restoration
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Alzheimer's & Dementia: Reducing Air Pollution, Preventing Dementia
Time of Update: 2022-05-22
Exposure to air pollution increases the risk of dementia, and important pollutant effects may precede dementia onset by years, if not decades .
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Alzheimer's & Dementia: Cerebrospinal fluid HDL particles predict Alzheimer's disease
Time of Update: 2022-05-22
Yassine et al hypothesized that small high-density lipoprotein (HDL) particles, through their ability to exchange lipids, affect neuronal membrane composition and vascular and synaptic function, thereby reducing the risk of Alzheimer's disease (AD) .
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at autopsy: Dementia with Lewy bodies (DLB) patients deteriorate faster than Alzheimer's disease (AD) patients!
Time of Update: 2022-05-22
A study published in Neurology aimed to compare the trajectories of key clinical features, including cognition, function, and dependence, among three autopsy-confirmed groups: AD, AD+DLB, and DLB .
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Biogen's Aduhelm is restricted by medical insurance, and Eisai, Eli Lilly and Roche accelerate the development of Alzheimer's disease treatment
Time of Update: 2022-05-21
Eisai said in a statement that the company expects to complete a rolling submission for lecanemab through the accelerated approval pathway in the coming months, following last week's CMS decision on Aduhelm's restrictive coverage .
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TauRx Alzheimer's Disease Drug Approved in China Phase III; dMed-Clinipace as Partner
Time of Update: 2022-05-20
) of China for an Investigational New Drug Application (IND) for the study of Trx-237-801 . dMed-Clinipace, a global clinical contract research organization (CRO) headquartered in Shanghai, has been
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Nature: More mutations accumulate in the brains of Alzheimer's patients
Time of Update: 2022-05-19
Co-first author Michael Miller, a pathology researcher at Brigham and Women's Hospital, said: "Our findings suggest that AD neurons experience genomic damage that can place enormous stress on the cell and cause dysfunction .
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Preventing Alzheimer's disease, this cholesterol marker has big implications
Time of Update: 2022-05-19
", the researchers measured and counted the size and number of HDL particles in the samples . >At the same time, the researchers administered cognitive tests to a subset of the participants
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"Nature" new discovery: Alzheimer's patients have many and different somatic mutations?
Time of Update: 2022-05-17
A new study by researchers at Brigham and Women's Hospital and Boston Children's Hospital finds that people with Alzheimer's have more somatic mutations in their brain cells than those without Alzheimer's.
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Why does Alzheimer's disease kill so many brain cells?
Time of Update: 2022-05-16
But in this study, the scientists found that, affected by Alzheimer's disease, the somatic mutations accumulated in nerve cells in the brains of patients were abnormal in both speed and type .
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Front. Neurosci.︱High-precision panorama of whole-brain Aβ plaques and surrounding structures in Alzheimer's disease model mice
Time of Update: 2022-05-10
and their simultaneous visualization with multiple brain structures(AF) Whole-brain visualization of signals from multiple brain structures in 6-month-old 5×FAD mice .
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JAMA Sub-Journal: Differences in Cortical PET Imaging Patterns in Preclinical Alzheimer's Patients
Time of Update: 2022-05-08
individuals at risk for AD and halting disease progression . preventionTo evaluate the prevalence of cortical tau positron emission
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Alzheimer&Dementia: Preventing Dementia Starts as a Baby - Diet and Exercise Can Affect Brain Neurogenesis Years Before Dementia
Time of Update: 2022-05-08
Several clinical studies have documented the protective effect of increased exercise on CD/dementia and revealed how greater adherence to the Mediterranean diet slows CD and reduces dementia risk .
