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AdTp: elastin-like polypeptide enhancement adeno-associated virus in Zongchao Han's research group
Time of Update: 2022-09-21
In view of this, the above immunogenic residues can be avoided by various ways to avoid the human immune response may improve the efficiency of gene therapy for some genetic diseases.
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Recombinant adeno-associated virus vector (rAAV) and the new observation of tumor risk
Time of Update: 2021-09-30
At the same time, Xiao Weidong's group also found that when different production systems were used to prepare different vectors, promoter-only SBG types accounted for different proportions in all different rAAV genomes (Figure 1C) .
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Research progress and prospect of adeno-associated virus in gene therapy
Time of Update: 2021-09-19
The therapy can induce gene expression or silencing of diseased cells, and has been successful in preclinical trials, but its clinical application is still limited by factors such as the immunogenicity, carcinogenicity, off-target effect and curative effect of the gene carrier .
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Thermo Fisher launches a new extended gene therapy portfolio to support more effective adeno-associated virus preparation
Time of Update: 2021-08-08
Recently, Thermo Fisher Scientific has launched a set of solutions that support the production of adeno-associated virus (AAV) to help gene therapy developers quickly and efficiently scale production .
The new solution aimed at producing higher quality viral vectors simplifies the purification process, resulting in higher AAV yields .
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/Insect Cell System: Adeno-Associated Virus-Based Products
Time of Update: 2021-02-22
The ability to make a large variety of virus-like particles (VLPs) has been successfully achieved in the baculovirus expression vector system (BEVS)/insect cell system.
This chapter focuses on the methodology, based on the work done in our lab, for the production of AAV-like particles and vectors in a BEVS/insect cell system.
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Photoreceptor Degeneration in Mice: Adeno-Associated Viral Vector-Mediated Delivery of Erythropoietin
Time of Update: 2020-11-30
The exogenous delivery of erythropoietin (EPO) and EPO derivatives (EPO-Ds) represents a valuable strategy to protect theretina from degeneration. In this chapter we describe a method to deliver EPO
