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The Brain-Yi Chenju/Niu Jianqin team found that activating the Wnt/β-catenin pathway relieved blood-brain barrier dysfunction in Alzheimer's disease
Time of Update: 2022-10-14
Written by - Wang Qi, Su Yixun Editor-in-Charge - Wang Sizhen Editor - Xia YeAlzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory loss and cognitive impairment.
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Br J Cancer: SLC38A4 regulates Wnt/β-catenin/MYC/HMGCS2 signaling pathway to inhibit the occurrence and development of hepatocellular carcinoma
Time of Update: 2021-07-27
Further revealing the key carcinoembryonic events during fetal liver development and HCC will provide new insights into the research of HCC occurrence and therapeutic targets .
Further revealing the key carcinoembryonic events during fetal liver development and HCC will provide new insights into the research of HCC occurrence and therapeutic targets .
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Prof. Zhuoyu Li: Hulu Su E produces chemical sensitivity to colorectal cancer cells by easing the TFAP4/Wnt/β-Catenin signaling path
Time of Update: 2020-12-12
this study, Peng Yang, Wen Liu, and Zhuoyu Li, of Shanxi University's Institute of Biotechnology (key laboratory of the Ministry of Chemical Biology and Molecular Engineering), among others, noted that CE enhances the sensitivity of CRC cells to chemotherapy by reducing the expression of box-type transport proteins ABCC1 and MDR1 by weakening adenosine 5'-triphosphate (ATP).
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Nat Commun:5-FU activates the WNT/β-catenin path, promoting the dryness of colorectal cancer.
Time of Update: 2020-10-30
The results of these studies suggest that p53 is a key medium for 5-FU to induce CSC activation through the WNT/β-catenin signaling pathrapy, and highlight the significance of WNT inhibitors and 5-FU combination therapy, which is a compelling treatment strategy that can improve the current adverse outcomes of 5-FU-based therapies in CRC patients.
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Br J Cancer: APC deficiency induces the Warburg effect of colorectal cancer cells by mediating the Wnt/β-catenin/PKM2 path.
Time of Update: 2020-10-29
the study sheds light on the key link between the Warburg effect and the abnormally activated Wnt/β-catenin signal transductive path, particularly in colorectal cancer (CRC), where APC (adenoma-related gene associated with colon pliosarcoma) is defunct.
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Cell Death Dis:FXR plays a carcinogenic role in colorectal tumors by antagoning the Wnt/beta-catenin signal.
Time of Update: 2020-09-23
study, we looked at the correlation between FXR and Wnt/beta-catenin signal transductivity paths during the development of colorectal cancer.
, the above results show that in colorectal cancer FXR can play its tumor suppression role through an antagonists of the Wnt/beta-catenin signal transduction path.
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Axin Ubigenization degradation, which relies on SIHA, is a powerful speed limit step for maintaining the Wnt/beta-catenin signal.
Time of Update: 2020-09-01
combined with in-cell knockout, molecular dynamics, and 3D structural studies, the researchers revealed that Axin Ubigenization degradation, which relies on SIHA, is a powerful speed-limiting step to maintain the Wnt/beta-catenin signal.
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The inhibition of human osteosarcoma cells through the Wnt/beta-Catenin pathway.
Time of Update: 2020-07-18
in addition, the luciferase activity in the evo treated group was significantly lower than that in the untreated group, and the expression level of the corresponding pathway protein also proved that Evo played an anti-cancer role in osteosarcoma cells by inhibiting Wnt / β - catenin signaling pathway.