Regulates Age-Associated/Autoimmune B-Cell Expansion and Lupus Pathogenesis. Arthritis Rheumatol. Accepted Author Manuscript. https://doi. org/10. 1002/art. 42146
A&R: Impact of impaired T-cell receptor signaling on gut microbiota in a mouse model of systemic autoimmunity
Time of Update: 2022-05-13
B6SKG mice had altered gut microbiota that was associated with the expansion of segmented filamentous bacteria and the development of SLE by driving Th17 cell differentiation , which in turn was impaired by IL-17 deficiency .
Professor Chen Qijun's research group revealed that dihydroartemisinin regulates spleen immune cell heterogeneity through SOD3-JNK-AP-1 signaling pathway
Time of Update: 2022-05-01
group from Shenyang Agricultural University published a research paper entitled "Dihydroartemisinin beneficially regulates splenic immune cell heterogeneity through the SOD3-JNK-AP-1 axis" in Science China Life Sciences, revealing that DHA regulates
team from Genentech discovered the neuronal signaling pathway that controls the proliferation of glial cells. Cell Press Dialogue with Scientists
Time of Update: 2022-04-27
The research group has defined a neuron-derived NMDAR-Ptgs2 signaling pathway, which can achieve transcellular control and regulation of glial cell proliferation during brain development and injury .
regulates the activation of Hippo signaling pathway and inhibits the growth of lung cancer cells
Time of Update: 2022-04-21
of the activity of MST1/2 and the phosphorylation of MOB1. . In this way, MOB1 acts as a "signal strength sensor", which senses the intensity of upstream oxidative stress and undergoes different
Huazhong University of Science and Technology Cell Rep reports that cholecystokinin signaling regulates instinctual escape behavior
Time of Update: 2022-03-08
motor neurons SMD and interneurons AIB . Real-time tracking of SMD neuron calcium activity during free escape turning, demonstrating that the NLP-18-CKR-1 signaling pathway can enhance the calcium
You Fuping's Team Reveals New Mechanism of Innate Immune Signals Regulating m⁶A Modification Cell Press Dialogue with Scientists
Time of Update: 2022-03-06
Professor You Fuping from the Institute of Systems Biomedicine, Peking University School of Medicine and the Department of Immunology, School of Basic Medicine is the corresponding author of the paper .
Molecular Cell: Liu Ying's research group revealed a new mechanism of amino acid regulation of mTORC1 signaling pathway activity
Time of Update: 2022-03-04
and thus affect downstream The biological process is unclear . >On February 2, 2022, Liu Ying's research group from the Institute of Molecular Medicine, School of Future Technology
Cell Reports Reveals Novel Mechanism of Innate Immune Signals Regulating m6A Modification
Time of Update: 2022-03-04
> >On February 15, 2022, You Fuping's team from Peking University School of Basic Medicine published a research paper titled "TBK1-METTL3 axis facilitates antiviral
Cell Rep identifies signaling mechanism in pancreatic cancer cells that may offer therapeutic targets
Time of Update: 2022-01-24
The results suggest that novel small-molecule drugs that inhibit ATR are being investigated for the treatment of several cancers, including PDAC, and could be used in combination with interferon "amplification" to block the escape ability of tumor cells .
Cell Prolif: LncRNA-AK137033 regulates the Wnt signaling pathway through DNA methylation
Time of Update: 2022-01-21
LncRNA-AK137033 inhibits the osteogenic potential of adipose-derived stem cells in diabetic osteoporosis by regulating Wnt signaling pathway via DNA methylation.
The unknown mechanism of T cell action before the publication of Science sub-journals: signaling pathways necessary for survival
Time of Update: 2022-01-09
survival independently of TCR and IL-7 signaling . Science Signaling , 2021; 14 (714) DOI: 10. 1126/scisignal. abj0057> >
Innovative therapy targeting Nobel Prize signaling pathway in renal cell carcinoma, disease control rate reached 98%
Time of Update: 2022-01-01
(MSD) for the treatment of renal cell carcinoma patients related to von Hippel-Lindau (VHL) disease were published in the New England Journal of Medicine .
Cell Res: Shanghai University of Science and Technology Liu Zhijie/Hua Tian team reveals the signal transduction mechanism of the schizophrenia target GPR139
Time of Update: 2021-12-30
coupling of the neuromodulatory orphan receptor GPR139" on Cell Research, revealing The three-dimensional structure of GPR139, small molecule agonists and different downstream signal transduction proteins Gq and Gi complexes are revealed, which reveals
Cell Research Liu Zhijie/Hua Tian team reveals the signal transduction mechanism of GPR139, a schizophrenia target
Time of Update: 2021-12-28
The mechanism of recessive symptoms of anti-schizophrenia and the safety of opioids have always been scientific
Cutting-edge targeting Nobel Prize signaling pathway, the disease control rate of innovative therapies for renal cell carcinoma reached 98%
Time of Update: 2021-12-05
(MSD) for the treatment of patients with renal cell carcinoma associated with von Hippel-Lindau (VHL) disease The results of a phase 2 clinical trial in the New England Journal of Medicine "Released on .
The latest advances in cell signaling and communication in cancer
Time of Update: 2021-12-03
In healthy cells, the dynamic processes of countless cells maintain good regulatory activities, including gene expression, energy and metabolic homeostasis, and cell division
BJH: Dexamethasone-mediated inhibition of Notch signaling blocks the interaction between leukemia and mesenchymal stromal cells
Time of Update: 2021-12-01
Using dexamethasone or Notch inhibitors to target the interaction of leukemia cells and AML MSCs may further improve treatment outcomes for AML patients Original source:Original source:Ahmed, HMM, Nimmagadda, SC, Al-Matary, YS, Fiori, M.
J Cell Physiol: Dapagliflozin improves pancreatic injury in obese rats and activates renal autophagy by modulating AMPK/mTOR signaling pathway
Time of Update: 2021-11-12
To explore the effects of dapagliflozin on insulin resistance, renal autophagy, pancreatic oxidative stress, endoplasmic reticulum stress, inflammation and cell apoptosis in obese rats induced by high-fat diet .