and defluorination cross coupling of inactive olefins and trifluoromethyl substituted olefins to prepare amphibole
Time of Update: 2020-02-15
Zhu Shaolin group, School of chemistry and chemical engineering, Nanjing University, reported a new method for the preparation of amphiphilic difluoroethylenes by the cross coupling of migration defluorination of inactive alkenes and trifluoromethyl substituted alkenes catalyzed by NIH.
: Study on ipso trifluoromethyl sulfurization without transition metal participation
Time of Update: 2019-08-27
Recently, the electrophilic trifluoromethylthio reagents with hyposulfonate structure developed by the research group of Shen Qilong of Shanghai organic Research Institute have been used for the first time to realize the transition metal free ipso SP 2-C trifluoromethylthio reaction (org.
JACS: selective C-F functionalization of non activated trifluoromethyl aromatic hydrocarbons
Time of Update: 2019-08-11
In the past few decades, due to the wide application of trifluoromethyl (CF 3) group in the field of drug design, people have developed many effective methods to construct arcf 3
JACS: palladium catalyzed asymmetric allylic trifluoromethylation reported by Trost et al
Time of Update: 2019-07-24
Of Stanford University reported the first palladium catalyzed asymmetric allylic trifluoromethylation reaction involving unique ligands for the first time.
: synthesis of 3-trifluoromethyl-3-hydroxy-1-cyclohexanone by intermolecular [4 + 2] cyclization promoted by internal oxidants catalyzed by copper
Time of Update: 2019-07-15
Source: Professor Jiang Huanfeng's research group cyclohexanone is a kind of structural unit widely existing in many natural products, bioactive molecules and reaction
Professor Wang Lei, Huaibei Normal University Research Group: synthesis of trifluoromethyl
Time of Update: 2019-06-03
Dihydroisoquinolinone is an important structural unit of some natural products and drug molecules
It has important biological activities, such as anti-tumor, anti
JACS: trifluoromethylation of C-H bond at benzyl site in aqueous phase
Time of Update: 2018-11-05
SOC.) further, the author studied the reaction mechanism of trifluoromethylation of C-H bond at the first, second and third benzyl positions (Figure 2).
[organic] angelw: palladium catalyzed efficient carbon sequestration direct synthesis of bis (trifluoromethyl) methanol derivatives
Time of Update: 2018-05-08
Recently, the team of troelsskrydstrup, University of Aarhus, Denmark, reported a method (scheme 1c) for direct conversion of bromide or aryl fluorosulfate to (hetero) aryl α, α - bis (trifluoromethyl) methanol by palladium catalyzed carbonylation strategy.
JACS: visible light catalysis and Lewis acid activation for single C (SP3) - f bond breaking of trifluoromethyl aromatic hydrocarbons
Time of Update: 2017-12-01
Under these conditions, the reaction has a good selectivity for breaking single C (SP 3) - f bond, and the product of defluorination is less than 5%.
JACS: Silver catalyzed deacidification and trifluoromethylation of aliphatic carboxylic acids
Time of Update: 2017-09-11
Trifluoromethyl (CF3) is a very important fluorine-containing group
Its van der Waals radius (2.7 Å), van der Waals volume (42.6 Å), electronegativity (χ = 3.5) [Y1
Trifluoromethylation of "jinshanshan"
Time of Update: 2017-06-27
Drug chemists like to introduce trifluoromethyl (CF 3) into the molecular structure of drugs, because the existence of C-F bond strengthens the stability of drug metabolism in vivo
Production technology of trifluoromethyl salicylic acid
Time of Update: 2007-02-01
Trifluoromethyl salicylic acid is the key raw material and intermediate of pesticide and medicine
Trifluoromethyl salicylic acid series products are widely used