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Identification of Protein-DNA Contacts with Dimethyl Sulfate: Methylation Protection and Methylation Interference

 Time of Update: 2021-02-26

Dimethyl sulfate (DMS) is an effective and widely used probe for sequence-specific protein- DNA interactions.
Clin Cancer Res: DNA methyl transferase inhibitor Guadecitabine combined with cisplatin and giscitabine to treat solid malignancies

 Time of Update: 2021-02-25

, guadecitabine combined with Giscitabine and Shunplain RP2D is 20 mg/m2 for 1st to 5th days and requires G-CSF to prevent bone marrow inhibition.
Yangzi Petrochemical pioneered the industrialization of toluene methylation technology

 Time of Update: 2021-02-24

catalytic reform and subsequent catalytic transformation and separation of python oil, which is one of the main target products of petrochemical industry, and the scale of development is seriously subject to the basic national conditions
Isolation of CpG Islands From BAC Clones Using a Methyl-CpG Binding Column

 Time of Update: 2021-02-12

Vertebrate genomes are globally heavily methylated at the sequence CpG with the exception of short patches of GC-rich DNA , usually between 1–2 kb in size, which are free of methylation and these are known as CpG islands ( see
Nature: Yuan Gang and others found that the increased activity of NSD3 histoprotein methylation led to the occurrence of lung squamous cell carcinoma

 Time of Update: 2021-02-11

NSD3 expression is closely related to gene amplification compared to other 8p11-12 candidate LUSC drivers.
methylation patterns of key developmental transcription factors

 Time of Update: 2021-02-10

During development, lowly differentiated cancer cells usually exhibit similar esopes to their linee pregenitor cells. in the development of normal organs are also reactivated in cancer cells, which also contributes to a large extent
with amines, modaphines and methyls: a randomized, crossover, double-blind trial

 Time of Update: 2021-02-04

during the illness. has a negative impact on health-related quality of life, with more than 50 percent of patients describing it as the most severe symptom of the disease. is a subjective symptom that is difficult to distinguish from
Nat Commun: Sarcoma classification tool based on DNA methylation analysis

 Time of Update: 2021-02-03

the study, researchers aim to develop a DNA methylation-based classification tool for labeling cartilage and osteosarcoma in various subsypes and age groups.
Dig Dis Sci: Methyl sulfonate is ineffective against the prevention of retrograde pancreatic bile tube oc inflammatory pancreatitis after endoscopy

 Time of Update: 2021-01-29

observations included risk factors for PEP and adverse events associated with NM.
Fully start Phase III clinical! Guoxin Pharmaceuticals has helped to conduct the first clinical trial of PEG-rhG-CSF biosynthic drugs in China

 Time of Update: 2021-01-27

in cancer patients. Guoxin Pharmaceuticals to undertake the entire course of the project clinical trial CRO services. cancer is an important disease that threatens human life at present, chemotherapy is one of the main treatment methods.
PEG precipitation method purification virus

 Time of Update: 2021-01-21

1, using ultrasound or freezing methods to break the cells to release the virus; 2, slowly stirring and adding NaCl final concentration is 0.5mol/L, helping the precipitation of the virus, and then the same amount added 10% PEG (generally
In Situ Analysis of DNA Methylation in Plants

 Time of Update: 2021-01-20

Epigenetic changes in the plant genome are associated with differential genome methylation, histone modifications, and the binding of various chromatin-binding factors.
Analysis of DNA Methylation in Plants by Bisulfite Sequencing

 Time of Update: 2021-01-18

We describe the application of bisulfite sequencing for the analysis of DNA methylation at defined individual sequences of plant genomic DNA.
Detection of Changes in Global Genome Methylation Using the Cytosine-Extension Assay

 Time of Update: 2021-01-18

Although there are various methods of methylation analysis, most of them are either laborious or expensive, or both.
The United States revised the maximum residual limit of methyl sulfon in sugar cane

 Time of Update: 2021-01-18

On March 27, 2019, the U.S. Environmental Protection Agency (EPA) issued document 2019-05877 to revise the maximum residual limit of Sulfometuron-methyl in sugar cane, according to the U.S. Federal Gazette.
Acta Neuropathologica: Transparent cell meningioma is defined as a highly different DNA methylation spectrum and SMARCE1 mutation

 Time of Update: 2021-01-15

In the study, the team described a molecularly different tumor substation, n-31, which was originally found in 3,093 meningoma queues through genome-wide DNA methylation screening, most of which were histologically diagnosed as transparent cell meningomas.
Analysis of Locus-Specific Changes in Methylation Patterns Using a COBRA (Combined Bisulfite Restriction Analysis) Assay

 Time of Update: 2021-01-15

Methylation analysis at a given locus allows one to evaluate levels of chromatin packaging, gene expression, and even homologous recombination.
Constructing Gene-Enriched Plant Genomic Libraries Using Methylation Filtration Technology

 Time of Update: 2021-01-13

The method reported here is a simple approach to generate gene-enriched plant genomic libraries called methylation filtration.
Professors Zhang Yan and Wang Shuo, Nanjia University: 2-amino-1-methyl-6-benzene-based methane and the composition of intestinal bacteria in rats

 Time of Update: 2021-01-12

biological antibody 3. Quality and safety control technology of food processing 4. Food safety risk assessment yl-6-phenylimidazo .4,5-b'pyridine Colon Injury by Disrupting the Intestinal Berry Composition and Lipid Metabolic Pathways in Rats published online at Journal of Agricultural and Food Chemistry.
For the first time, the high-resolution structure of de novo DNA methyl transferase and natural

 Time of Update: 2021-01-05

The Xu Huaqiang Task Force of the Shanghai Drug Research Institute and the Peter Jones Task Force of the Wen'anlo Institute of the United States and the Karsten Melcher Task Force published the important research results entitled Structure

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