>Proteolysis targeting chimera (PROTAC) is a bifunctional small molecule, in which the target protein ligand and E3 ubiquitin ligase ligand are linked together by a linking arm.
ACS Chem Neuro: Polymeric estrogen has the effect of protecting nerves
Time of Update: 2021-05-23
March 21, 2021 //---According to a recent study, a new type of polymeric estrogen developed by the Rensselaer Institute can provide neuroprotection when implanted in the spinal cord injury site, thereby preventing further damage.
Chem: To achieve deeper tumor photodynamic therapy, Zhejiang University Deng Renren/Zhou Min team develops new photosensitization technology
Time of Update: 2021-04-23
low-power density 808 nm laser irradiation. Compared with the traditional singlet-triple state PDT method, the lanthanide-triple state sensitization method has deeper tumor penetration and stronger anti-tumor
Nat Chem Biol | Rao Yu/Ying Meidan team designed CDK2 degradation agent and applied it to AML differentiation treatment
Time of Update: 2021-03-23
This work reports a new type of CDK2 selective degrading agent that achieves high-efficiency and low-toxicity in AML cell differentiation therapy, and provides a potential differentiation therapy for AML therapy.
Human progesterone (PROG) enzyme-linked immunology analysis (ELISA)
Time of Update: 2021-02-28
only Purpose: This kit is used to determine human serum , the cells were cleared
J AGR FOOD CHEM: A high-salt diet may damage the liver
Time of Update: 2021-02-16
A new study published in the journal Journal of Agricultural and Food Chemistry suggests that a high-salt diet can also lead to liver damage in adults and embryos.
Crude oil tank corrosion prevention must be conductive inorgable anti-corrosion paint
Time of Update: 2021-02-09
tanks doubled, the demand for oil storage tank coatings also surged, the quality requirements of coatings are also increasing. With the development of storage tank construction, the amount of coatings for future maintenance and maintenance will gradually
The excellent economic performance of water-based inorgable steel structure anti-corrosion coatings is of great significance
Time of Update: 2021-02-06
is expensive, the price is several times to ten times the specifications of ordinary high-quality steel, and the service life is limited. Other corrosion-resistant materials are mainly not strong enough, limited service life, poor economy and a series
Nat Chem Biol: Fbxo48 inhibitors reduce insulin resistance by preventing pAMPK alpha degradation
Time of Update: 2021-02-02
is considered an attractive therapeutic target for a wide range of diseases. in the recent study "A Fbxo48 inhibitor prevents pAMPK alpha degradation and ameliorates insulin resistance", researchers say they have identified an orphan Ubithin E3
CLIN CHEM LAB MED: High-efficiency liquid chromatography-series mass spectrometry to simultaneously
Time of Update: 2020-12-11
this study describes the effectiveness of liquid chromatography series mass spectrometry (LC-MS/MS) for simultaneous determination of HCQ and its two main metabolites, deethyl chloroquine (DCQ) and DDDCQ.
Heavy! Win paid $625 million for Peroxy Chem
Time of Update: 2020-12-10
Umtron's $625 million acquisition of PeroxyChem 's business to enhance the resource efficiency of the growth segment expanding hydrogen peroxide's high-margin specialty applications its strong growth and sound financial position
Prog. Neurobiol: The effects of chronic drinking on the brain's immune system
Time of Update: 2020-11-28
lecierle interletin 10 or IL-10, which is common in the brain. , IL-10 has powerful anti-inflammatory properties that ensure that the immune system is a threat to the disease in the brain, and IL-10 helps reduce disruption caused by injuries
Ang Chem Int Ed: Scientists have developed a new collaborative anti-cancer combination therapy that could hopefully target multiple types of cancer
Time of Update: 2020-11-01
are too low to produce enough reactive oxygen, so scientists used a modified system to partially recover oxygen, in which photosensitive agents produce reactive oxygen when exposed to light. Enzymes in cells convert reactive oxygen into hydrogen
Encyclodediency knowledge of inorgeable pigments.
Time of Update: 2020-10-24
inorderable color pigments can be used in a variety of fields, including coil coatings, powder coatings, industrial coatings, architectural coatings, etc., and are also used to provide colors for plastics, construction and other fields.
$640 million! Ingtron successfully completed the acquisition of Peroxy Chem.
Time of Update: 2020-10-22
the combined global business to generate $20 million in synergies, the same as previously reported figures, particularly in operations and logistics, product portfolio expansion and new technology development. These synergies will be fully realized
Analy Chem: Scientists have developed new tools to study the function of the human body's immune system.
Time of Update: 2020-10-22
15, 2020 // -- In a recent study published in the international journal Analytic Chemistry, scientists from the University of Alberta and other institutions developed a new tool to help study the function of the human body's immune system
Nat Chem Biol: Reveals the molecular structure of the effective treatment of multiple myeloma with the drug Pomadamine.
Time of Update: 2020-10-13
: Yamamoto, J., Suwa, T., Murase, Y. et al. ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells. Nat Chem Biol (2020).doi:10.1038/s41589-020-0645-3.
Clin Chem: A year of vitamin D supplementation and marine Omega-3 fatty acids did not reduce systemic inflammatory status in older adults.
Time of Update: 2020-10-10
Observational studies have shown that vitamin D and marine omega-3 fatty acid (n-3 FA) supplements are associated with a decrease in systemic inflammation. , however, past test results have not been consistent. this randomized, double
J Biol Chem: Study reveals why Redsyvir may be treating new coronaviruses!
Time of Update: 2020-10-03
), and they hope it may also be effective in treating patients infected with the new COVID-19 strain. even if you know a drug works, if you don't know how it works, it can be a red flag," said Mattias Gtte, a virologist at the University of New China