> In November 2021, the UK’s Medicines and Healthcare Products Regulatory Agency (MHRA) approved monupiravir for the treatment of adults with mild to moderate new coronary pneumonia, priced at $709 per course of treatment
Saisheng Pharmaceutical's Small Molecule Conjugate Drug Application for Clinical Application
Time of Update: 2022-05-25
PEN-866 is a small molecule drug conjugate (SMDC) developed by Saison Pharmaceuticals and is currently conducting a Phase II basket trial for solid tumors in the United States .
Research on the construction of sub-nanoscale Pd and Pt metal clusters to achieve efficient dehydrogenation of organic hydrogen molecules
Time of Update: 2022-05-20
Sub-nanoscale fully exposed Ptn metal cluster catalytic material for efficient dehydrogenation of cyclohexane to hydrogen production (J.
Aquatic Institute discovers a new molecule as a carbon sink in the oil-producing marine Nannochloropsis
Time of Update: 2022-05-14
Recently, the research group used Nannochloropsis marine as the object to reveal the important role of PDAT in regulating lipid metabolism and pooling intracellular carbon flow, and found that cells synthesize a new carbon replacement for TAG under stress conditions.
molecules by the communication between the fungi where microorganisms are located
Time of Update: 2022-05-13
mso-bidi-font-family:Helvetica'>Yin Wenbing's research group at the Institute of Microbiology, Chinese Academy of Sciences has been working on the gene regulation mechanism and function of fungal secondary metabolites .
The small molecule targeted drug market is growing rapidly and will reach 100 billion yuan in 2025
Time of Update: 2022-05-12
Small molecule drugs have great potential in the current treatment of tumors and non-tumor diseases. In recent years, with the expansion of medical insurance coverage, the continuous
Cell Research: Neuroprotective Small Molecule Agonists of NAD Biosynthetic Enzymes
Time of Update: 2022-05-11
is to supplement NAD precursors, such as NR, NMN, NAM or NA. There are several relevant clinical trials underway internationally, and NMN and NR have been used as anti-aging health care products or foods. Hot selling in the market
Nature Deng Hongkui's team published major research results - chemical small molecules induce human adult...
Time of Update: 2022-05-11
determination and transition, but also brings new possibilities for future regenerative medicine to treat major diseases . >In this study, Deng Hongkui's team reported
Progress in the study of novel small molecule mechanism of inter-fungal communication activation
Time of Update: 2022-05-09
the co-culture system of Aspergillus nidulans and Dendrobium as a model, Yin Wenbing's research group analyzed its response mechanism from the aspects of biology, chemistry and genetics .
Protein-degrading drugs and molecular glues account for one-third of the "Drug Hunters" annual list of small molecules
Time of Update: 2022-05-03
Revolution Medicines' KRAS G12C inhibitorRevolution Medicines' KRAS G12C inhibitorImage source: Reference [1]RM-018, developed by Revolution Medicines, is a small molecule inhibitor that inhibits the activity of KRAS G12C mutants by binding to their activated state .
Roche collaborates to develop brain-penetrating oral small molecules for neurodegenerative diseases
Time of Update: 2022-05-01
Aquinnah announced today that it has entered into an R&D agreement with Roche to advance the development of brain-penetrating oral small molecules for the treatment of amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases .
The PD-1/L1 track is inward, can small molecule drugs become the key to breaking the game?
Time of Update: 2022-05-01
Ascletis - ASC61 On January 10, 2022, Ascletis Pharma announced that ASC61, an oral PD-L1 small molecule inhibitor developed by itself, has been submitted for a US clinical trial application (IND) for the treatment of advanced solid tumors .
Nature: Uncovering the mechanism of bacterial rescue molecule SmrB to clear ribosome collision
Time of Update: 2022-04-29
"Ribosome collisions induce mRNA cleavage and ribosome rescue in bacteria" are described March 9, 2022 in the journal Nature by Beckmann, Green and a team of scientists in her lab led by Allen Buskirk .
Mol Cell Shi Yun et al. Reveal the mechanism of small molecule inhibitor against axonal degeneration
Time of Update: 2022-04-28
Structural Basis of SARM1 Activation, Substrate Recognition, and Inhibition by Small Molecules.
[Nature sub-issue] Marine bacteria make "anti-cancer molecules", and scientists understand the mystery for the first time!
Time of Update: 2022-04-28
>. For the first time, scientists now understand the enzyme-driven process that activates the molecule . The research solves
A new class of pteridone A2AR small molecule antagonists with high activity in the environment of high concentration of adenosine
Time of Update: 2022-04-27
This paper discovered a new class of pteridone A 2AR small molecule antagonists that maintain high activity in a high-concentration adenosine environment , showing good tumor immunotherapy potential .
