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"Nature" heavy: Chinese scientists crack the mechanism of action of metformin

 Time of Update: 2022-05-23

▲Metformin binds to PEN2 to activate AMPK (Image source: Reference [1])Next, the research team revealed the pathway by which metformin works based on this newly discovered target .
Nature: Widespread brain receptor hides surprising mechanism of action

 Time of Update: 2022-05-17

Rather than a direct step-by-step transition, Sobolevsky and his colleagues found that the glutamate molecule must first bind to one of two specific subunits of the receptor before it can bind to the other two .
Science Advances: Massachusetts General Hospital discovers the regulation mechanism of natural

 Time of Update: 2022-05-14

A new study from Massachusetts General Hospital reveals the interaction between affecting natural killer (NK) cells -- which are part of the body's innate or first-line immune response -- and tumor cells, viral infections and solid organ transplantation.
Cell: Mechanism of action of GPCRs

 Time of Update: 2022-05-12

"In our study, we used an approach that allowed us to explore, in unprecedented detail, how drug-stimulated GPCRs activate β-arrestin, a protein that both terminates some signals and mediates others ” said Wesley B.
JCI: Shen Zhanlong's team from Peking University People's Hospital reveals the mechanism of action

 Time of Update: 2022-05-09

screen patients who benefit from PD-L1 inhibitor therapy, from single-cell precision Revealed a new mechanism of immunotherapy targeting TAM cells and dendritic cells (DC), and discovered a new mechanism of ubiquitination regulation with better
Researcher Wu Haoxing's team published a hot paper in Angew. Chem.: Revealing the general design

 Time of Update: 2022-04-26

the general design method and mechanism of new near-infrared bioorthogonal fluorescent probes, and further expands the application of bioorthogonal chemistry in molecular imaging, in vivo biomedicine and other fields
The General Administration launched a special rectification action for the inspection and testing market in 6 major areas

 Time of Update: 2022-04-26

>　　(1) Carry out special rectification actions in six major areas . According to the principle of territorial jurisdiction, local market supervision departments should concentrate
spike protein and its complex structure with receptors and antiviral antibodies, and revealed the mechanism of action

 Time of Update: 2022-03-08

to the spike protein of the Omicron variant was 4 times that of the wild type, showing the potential to inhibit the Omicron variant . From the resolved complex structure, the research team found
Tsinghua University School of Pharmacy Tang Yefeng's group and their collaborators discovered anti-mycobacterial compounds with new mechanism of action

 Time of Update: 2022-03-08

bovis BCG raised against the compound Table 4 Mutations in the IND resistant mutants of M.
Significant improvement in dry eye symptoms New mechanism of action eye drops Phase 2 clinical results are positive

 Time of Update: 2022-02-23

Recently, Aldeyra Therapeutics announced positive top-line data from a Phase 2 clinical trial of its investigational therapy reproxalap eye drops in patients with dry eye disease .
Molecular mechanism of bacterial effector proteins antagonizing host antibacterial autophagy and a general mechanism of cell-selective autophagy

 Time of Update: 2022-02-20

, the team of Shao Feng from the Beijing Institute of Biological Sciences revealed the molecular mechanism of heterophagy for the first time . After bacteria invade the host cell, the V-ATPase
The unknown mechanism of T cell action before the publication of Science sub-journals: signaling pathways necessary for survival

 Time of Update: 2022-01-09

survival independently of TCR and IL-7 signaling . Science Signaling , 2021; 14 (714) DOI: 10. 1126/scisignal. abj0057> >
Deqi Pharmaceutical's first product, Civio®, was approved for the market, and the new mechanism of action has broad application prospects｜Press release

 Time of Update: 2021-12-30

Stock Exchange stock code: 6996. HK) announced today that the National Medical Products Administration (NMPA) has approved The new drug application (NDA) of Civio® (Celinisol, ATG-010), through the combination with dexamethasone
Innovative Mechanism of Action Novartis Leukemia Therapy Receives FDA Approval

 Time of Update: 2021-12-03

Retrieved October 29, 2021, from https:// 29/2323914/0/en/FDA-approves-Novartis-Scemblix-asciminib-with-novel-mechanism-of-action-for-the-treatment-of-chronic-myeloid-leukemia.
Express Innovative Mechanism of Action, Novartis Leukemia Therapy Receives FDA Approval Today

 Time of Update: 2021-11-15

▎The content team editor of WuXi AppTec today, Novartis announced that the US FDA has approved Scemblix (asciminib) for the treatment of two different indications of chronic myeloid leukemia (CML) .
[Cancer Cell] Chinese scholars reveal the mechanism of action of Anti-PD-L1 immunotherapy combined with chemotherapy in triple-negative breast cancer

 Time of Update: 2021-11-14

groups of pro-inflammatory macrophages with high expression of CXCL9 and CXCL10, and these two groups were pro-inflammatory There is a significant positive correlation between sex macrophages and CXCL13+ T cells (Figure 3)
sterol relieves atherosclerosis and its potential mechanism of action

 Time of Update: 2021-11-14

Sargassum fusiforme Modulates Cholesterol Metabolism and Alleviates Atherosclerosis in ApoE-Deficient Mice" by Ying Hao Research Group of the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences. Research results
Cancer Cell Chinese scholars reveal the mechanism of action of Anti-PD-L1 immunotherapy combined with chemotherapy in triple-negative breast cancer

 Time of Update: 2021-11-11

under different treatment options> >In addition, the researchers found that the tumor microenvironment of the responding patients was enriched in two groups of pro-inflammatory macrophages with high
"Nature" study reveals the mechanism of glycoprotein hormone action

 Time of Update: 2021-11-05

Recently, researcher Xu Huaqiang, researcher Jiang Yi, and researcher Zhang Yan of Zhejiang University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, jointly published research papers in the top academic journal "Nature
Cancer Cell: Zhang Zemin's team and others reveal the mechanism of action of anti-PD-L1

 Time of Update: 2021-11-02

is ineffective against hormone therapy and targeted therapy. At present, traditional chemotherapy is the main treatment method, but the effect is not satisfactory . >Although cancer immunotherapy has entered a period

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