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Introduction of primary antibody and secondary antibody type, specificity and selection method in experiment
Time of Update: 2022-08-30
Which class or subclass does the primary antibody belong to Fragment specificity: 3.
Which class or subclass does the primary antibody belong to Fragment specificity: 3.
Which class or subclass does the primary antibody belong to Fragment specificity: 3.
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Nature Biotechnology: a high-fidelity Cas13 system with higher specificity and better safety
Time of Update: 2022-08-19
article titleHigh-fidelity Cas13 variants for targeted RNA degradation with minimal collateral effects Figure: Design, screening, and description-engineered high-fidelity Cas13 variants A new study has revealed that through mutation, the development of high-fidelity Cas13 variants significantly reduces collateral effects .
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BJH: The specificity of the manifestations and treatment of primary immune thrombocytopenia in elderly patients
Time of Update: 2021-12-01
The purpose of a foreign study is to evaluate the clinical manifestations and management of primary ITP in very elderly patients (VEPs: age ≥ 80 years) and elderly patients (EPs: age 65-79 years), and to determine risk factors for bleeding at the initial presentation .
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Neurology: What is the clinical specificity of cerebral venous thrombosis?
Time of Update: 2021-09-29
CVT in adolescents is rare and complex, with special epidemiological characteristics , including differences in clinical manifestations and related conditions between different sexes, as well as more serious results than adults .
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C-to-G single-base editor based on deep learning algorithm to optimize sequence specificity
Time of Update: 2021-08-28
The research established the deep learning model algorithm CGBE-SMART , which can accurately predict new types Single-base editing efficiency and editing effects of OPTI-CGBEs .
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It is the first report that extracellular vesicles are rich in lncRNA-encoded polypeptides/small proteins and have certain disease specificity
Time of Update: 2021-08-26
On July 12, 2021, the team of Researcher Yang Fuquan from the Institute of Biophysics of the Chinese Academy of Sciences, the team of Academician Runsheng Chen, and the team of Professor Hongwei Zhang from Beijing Sanbo Brain Hospital published an online publication titled " Journal of Extracellular Vesicles", an international authoritative journal in the field of extracellular vesicles .
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The study reveals the developmental space-time specificity of cell esoteric variation
Time of Update: 2021-03-14
Through real-time imaging and single-cell quantitative analysis of the embryo development of the beautiful reclusive rod nematode, the team found that the variation of normal embryonic cell positioning has a high degree of certainty and consistency over time, regulated by internal and external mechanisms.
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The study found gender specificity in Alzheimer's therapy
Time of Update: 2021-03-04
many drug candidates may have different effects between different genders, we need to be extra cautious in our future clinical trial designs," said Abdelrahman, a research institute.
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Nat Commun: Molecular signs of breast cancer in Asia reveal the specificity of the disease in the population
Time of Update: 2020-12-31
molecular subtype analysis of breast cancer patients in Malaysia In this study, the researchers analyzed the number of genetic mutations, transcriptions and copies in 560 malaysian breast tumor patients, and compared the incidence of breast cancer in Asian and white women.
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An in vitro assay to study the recruitment and substrate specificity of chromatin modifying enzymes
Time of Update: 2020-12-10
In this paper, we describe a novel assay that allows sequential targeting of distinct histone modifying enzymes to immobilized nucleosomal templates using recombinant chimeric targeting molecules.
As such the assay can help to understand how a certain histone code is established and interpreted.
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A rapid and sensitive assay for quantification of siRNA efficiency and specificity
Time of Update: 2020-11-24
This assay system is applicable to any RNAi study where there is a risk of targeting homologous genes and to the monitoring of off-target effects at the genome level following microarray expression profiling.
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Enzyme properties experiment - enzyme specificity
Time of Update: 2020-11-03
With buffer solution to the scale, fully shake, with two layers of gauze or four layers of gauze filtration, absorb the filter 5 ml, into a 100 ml capacity bottle, diluted with distilled water to the scale, the resulting liquid is diluted 2000 times the enzyme solution.
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Whether PRC2 binds to RNA has sequence specificity studies.
Time of Update: 2020-09-13
The international academic journal Scientific Reports recently published online a sequence-specific study of the interaction between PRC2 and long non-coding RNA (lncRNA) by the Research Group of the Chinese Academy of Sciences-Mapp Institute of Computational Biology, "The PRC2-binding long non-coding RNAs in human and mouse genomes with associated predictive sequence features".
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THE ALPHA3 helix of TEAD4 determines the specificity of the identified DNA.
Time of Update: 2020-09-06
On April 5, the international academic journal Oncogene published online the latest research results of the Research Group DNA-binding mechanism of the Hippo pathway transcription factor TEAD4 of the Institute of Biochemistry and Cell Biology/Molecular Cell Science Innovation Center of the Shanghai Institute of Life Sciences of the Chinese Academy of Sciences.
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The composition of protein aggregates affects their autophagy degradation efficiency and specificity.
Time of Update: 2020-08-25
On August 14th, Zhang Hong of the Institute of Biophysics of the Chinese Academy of Sciences published a research paper entitled The composition of a protein aggregate modulates the specificity and efficiency of its autophagic degradation in the journal Autophagy, which explains how the composition of protein aggregates affects their autophagy degradation efficiency and specificity.
