Automated Structure Verification of Small Molecules Libraries Using 1D and 2D NMR Techniques
Time of Update: 2021-03-05
The purity control and the structure verification of compound collections from automated synthesis and combinatorial chemistry play an essential role in the success of medicinal chemistry programs. High performance liquid chromatography
Structural and Functional Changes in the Insulin Molecule Produced by Oxidative Stress
Time of Update: 2020-12-02
The change produced by oxidative stress on proteins (cross-links, backbone cleavage, amino acid modification) generates structural changes with a wide range of consequences such as increased propensity to the aggregation or proteolysis
The structure and function of several important types of protein molecules mediated by single trans-membrane conductor signal transductivity.
Time of Update: 2020-10-26
In unstilled cells, MAPK is stationary, and when it receives the phosphatation regulatory signal of the upstream molecule MAPKK (MAp Kinase Kinase), the adjacent suline and tyrosine in mapK are phosphatized, thus becoming the active form of MAPK.
Progress has been made in the study of asymmetric reductamine construction hand 1,4-nitrous zodiazepine structure modules in enzyme-promoting molecules.
Time of Update: 2020-09-16
sleep. , the efficient synthesis of The Handy 1,4-Nitrous Zodiac Ring, a key structural unit of Suvoreson, is still challenging. The bio-catalytic and green chemical team led by Zhu Dunming and Wu Qiqing, researchers at the Tianjin
The 3D atomic structure of protein molecules.
Time of Update: 2020-09-13
, a doctoral student at the University of Toronto and one of the researchers, explains that determining the structure of 3D atoms in protein molecules is critical to understanding how they work and how they respond to drug treatment.
Based on single-molecule imaging: a new method of structural analysis.
Time of Update: 2020-09-12
/> this method does not require large molecules to form crystals, and combined with other sample preparation methods, frozen etched electron mirrors have become a hot topic in the field of single-molecule imaging and can be used to parse more than 50 thousand
NMR structure of the V-shaped G-quad-chain complex between DNA molecules.
Time of Update: 2020-08-06
Recently, Zhang Sodium, a researcher at the Center for Strong Magnetic Field Science at hefei Material Science Institute of the Chinese Academy of Sciences, used nuclear magnetic resonance (NMR) technology to analyze the intermolecular V-shapeD G
of technology on the structure and dynamic behavior of water molecules in blue phosphorus nanopores
Time of Update: 2019-09-15
At the same time, the realization of molecular scale observation and the maintenance of the intrinsic properties of water are very harsh for the selection of the model system of STM with atomic resolution.
Nat commun: scientists use small molecules to change the three-dimensional structure of DNA, which is expected to develop new anticancer drugs
Time of Update: 2019-04-28
April 28, 2019 / BIOON / - researchers found that small molecular compounds can change the spatial structure of genome, which are considered to be promising anticancer drugs.
Research group of Professor Ma Yanming of Jilin University: if8 molecules with supervalent cubic structure induced by pressure
Time of Update: 2019-02-13
The author of the paper: Ma Yanming's research group's oxidation state reflects the chemical state of elements in compounds and their electronic gains and losses in the chemical