-
JAMA sub-journal: Xu Ruihua/Qiu Miaozhen team of Sun Yat-sen University reveals for the first time
Time of Update: 2023-02-03
Subsequently, Xu Ruihua's team compared the somatic variation burden of Chinese HDGC patients and TCGA sporadic diffuse gastric adenocarcinoma (D-STAD) patients, and found that the frequency of gene mutations in the two cohorts was significantly correlated (R=0.
-
Nature sub-journal: Gao Qiang/Huanghe team to draw the mastoylation modification map of liver cancer tissue
Time of Update: 2023-02-03
In 2019, Professor Yingming Zhao's team at the University of Chicago discovered that lactic acid in mammalian cells can drive the formation of a novel histone post-translational modification (PTM), lysine lactylation (Kla), which in turn plays an important gene transcription regulatory function, thus proposing new insights into the non-metabolic function of lactic acid 。 As one of the key organs of glycolipid metabolism, various lesions of the liver are closely related to metabolic abnormalities.
-
Tumor "God Journal" published: "Weight loss" helps reduce the risk of 13 types of cancer!
Time of Update: 2023-01-06
Weight loss may reduce cancer risk by 32%!The results were impressive: compared with the non-surgical control group, the bariatric surgery group had a 32% lower incidence of 13 obesity-related cancers (esophageal adenocarcinoma, renal cell carcinoma, postmenopausal breast cancer, cardia cancer, colon cancer, rectal cancer, liver cancer, gallbladder cancer, pancreatic cancer, ovarian cancer, body cancer, thyroid cancer, and multiple myeloma) and a 48% lower risk of cancer death.
-
Tumor "God Journal" published: "Weight loss" helps reduce the risk of 13 types of cancer!
Time of Update: 2023-01-06
Weight loss may reduce cancer risk by 32%!The results were impressive: compared with the non-surgical control group, the bariatric surgery group had a 32% lower incidence of 13 obesity-related cancers (esophageal adenocarcinoma, renal cell carcinoma, postmenopausal breast cancer, cardia cancer, colon cancer, rectal cancer, liver cancer, gallbladder cancer, pancreatic cancer, ovarian cancer, body cancer, thyroid cancer, and multiple myeloma) and a 48% lower risk of cancer death.
-
KN026 Second-line treatment of HER2-expressing gastric cancer or gastroesophageal junction cancer
Time of Update: 2023-01-05
Suzhou, China, November 23, 2022 – Corning Jerry Biopharmaceuticals (stock code: 9966. HK) and CSPC Pharmaceutical Group (stock code: 1093. HK) HK) jointly announced that the results of the phase II.
-
Science sub-journal: Developed a CAR combined screening method to determine the most effective CAR-T cells for cancer treatment
Time of Update: 2023-01-05
Now, in a new study, researchers from the University of California, San Francisco, have developed a new way to compare large numbers of CAR-T cells, each with slightly different molecular characteristics, to determine which CAR-T cells are most effective and durable against cancer 。 The results were published in the Nov. 9, 2022 issue of Science Translational Medicine as "Pooled screening of CAR T cells identifies diverse immune signaling domains for next-generation immunotherapies.
-
Nature sub-journal: Wang Cun/Qin Wenxin et al. of Shanghai Jiao Tong University published a review
Time of Update: 2023-01-04
Immunomodulatory effects of molecular targeted agents (Image from Nature Reviews Gastroenterology & Hepatology)Subsequently, more successful projects have been completed, leading to regulatory approvals for lenvatinib, cabozantinib and ramucirumab, as well as breakthrough combination therapies for atezolizumab + bevacizumab.
-
Nature sub-journal: Sun Yat-sen University Song Erwei/Luo Manli discovered potential new mechanism of aromatase inhibitor resistance in breast cancer
Time of Update: 2023-01-04
On November 22, 2022, Sun Yat-sen University Song Erwei and Luo Manli jointly published a report on Nature Communications The study paper "Long noncoding RNA DIO3OS induces glycolytic-dominant metabolic reprogramming to promote aromatase inhibitor resistance in breast cancer," which showed aromatase inhibitors (AI).
-
junction cancer were published in the internationally renowned journal EJC
Time of Update: 2023-01-01
About KN026 KN026 is a HER2 bispecific antibody developed by Corning Jereh using Fc heterodimer platform technology (CRIB) with independent intellectual property rights, which can bind two non-overlapping epitopes of HER2 at the same time, resulting in HER2 signal blockade, which is better than the combination of trastuzumab and pertuzumab, such as showing higher affinity, and has a potent tumor suppressor effect in HER2-positive tumor cell lines.
-
Science sub-journal: How does oil smoke induce lung cancer? Scientists have found that long-term
Time of Update: 2022-12-30
The team found that long-term inhalation of nanoscale carbon black particles of 15-75nm can lead to mitochondrial damage and metabolic reprogramming of lung macrophages, which in turn leads to increased lactic acid secretion and immunosuppressive microenvironment formation, promoting the occurrence and metastasis of lung cancer.
-
Nature sub-journal: Prevention of serious side effects of chemotherapy used to treat breast cancer patients
Time of Update: 2022-12-29
essayA non-coding GWAS variant impacts anthracycline-induced cardiotoxic phenotypes in human iPSC-derived cardiomyocytes Researchers at Indiana University School of Medicine are learning more about ways to prevent the serious side effects of chemotherapy used to treat breast cancer patients.
-
Cell sub-journal: DNA repair defects may lead to BRCA-related cancers
Time of Update: 2022-11-26
Photo by Weill Cornell MedicineAccording to a new study from Weill Cornell Medical College, individuals who inherit a mutated copy of the BRCA1 gene can have error-prone DNA replication and repair that can lead to mutations and cancer.
-
JAMA sub-journal: Walking 10,000 steps a day can effectively reduce the incidence and mortality of cancer and cardiovascular diseases
Time of Update: 2022-11-25
409) published an article examining the association between daily steps and walking intensity and all-cause morbidity/mortality of all-cause mortality, cancer, and cardiovascular disease (CVD), finding that the risk of all-cause mortality, cancer death, and CVD death tended to decrease significantly as the number of steps per day increased, and the highest health benefits were achieved when walking about 10,000 steps per day。This prospective cohort study included 78,500 participants (mean age 61±8 years) with a total of 7 years of follow-up.
-
Cell Journal (IF=17) Zu Xiongbing's team at Central South University discovered a safe
Time of Update: 2022-11-01
Immune checkpoint blockade (ICB), including anti-PD-1/PD-L1, has shown promising survival benefits and revolutionized the status quo of treatment for patients with advanced MIBC.
Original link: #—END—content is 【iNature】 Immune checkpoint blockade (ICB), including anti-PD-1/PD-L1, has shown promising survival benefits and revolutionized the status quo of treatment for patients with advanced MIBC.
-
【Science Sub-Journal】Shocked! A team of foreign universities found that it is the culprit
Time of Update: 2022-11-01
This article is the original of Translational Medicine Network, please indicate the source of reprinting Written by SophiaPancreatic cancer, a particularly aggressive pancreatic cancer, is pancreatic