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algorithm that revealed that adaptive mutations are associated with disease susceptibility
Time of Update: 2022-09-30
Recently, the team of Professor Zhu Hao of Southern Medical University in China published a research article entitled "Uncovering the extensive trade-off between adaptive evolution and disease susceptibility" in the journal Cell Reports 。 The research team has developed a deep learning algorithm called DeepFavored, which can distinguish between favorable mutations and "free-rider" mutations by statistically testing existing genome-wide association study (GWAS) datasets.
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ARD: lifetime risk of interstitial lung disease associated with rheumatoid arthritis in MUC5B mutation carriers
Time of Update: 2022-01-08
Based on the strongest known risk factor for pulmonary fibrosis (a MUC5B promoter mutation), the lifetime risk of developing rheumatoid arthritis-related interstitial lung disease (RA-ILD) is assessed .
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Hepatocyte mutations associated with liver disease and fat metabolism
Time of Update: 2021-11-04
In addition, although more research is needed, this research may lead to a potential new model to understand how mutations in specific cell types can lead to systemic metabolic diseases, such as diabetes .
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Nat Genet: Genetic mutations associated with immune cells may affect an individual's risk of developing autoimmune diseases.
Time of Update: 2020-10-06
In the study, researchers studied blood samples from 3,500 participants in sardinia, Italy, using genotype spectrometry and attribution analysis as a means of finding mutations involving 731 immune cell properties, including the use of cell surface markers and cell segments based on fluid cytometry.
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Brain: First time! Xiangya Hospital, Central South University, mapped the genetic mutations associated with Parkinson's disease in China.
Time of Update: 2020-07-18
first systematically drew the mutation map of the Parkinson disease related gene in Chinese mainland, and provided genetic evidence for the treatment of Parkinson disease.
