-
Science| Synaptic type-specific local protein synthesis regulates cortical junctions
Time of Update: 2023-02-02
1038/ncb840; pmid: 12172554Reprint instructions【Original article】BioArt original article, welcome to share by individuals, reproduction is prohibited without permission, the copyright of all works published is owned by BioArt. BioArt reserves all statutory rights and violators will be prosecuted.
-
Nature publishes a "truly useful" cell atlas: containing more than 300 types of protein kinases found in human cells
Time of Update: 2023-02-01
Original:An atlas of substrate specificities for the human serine/threonine kinome Protein kinase, the most important class of enzymes in humans, is a signaling molecule that regulates almost all cellular activities, including growth, cell division, and metabolism.
-
Rheumatology: HOXA5 is a key regulator of the expression of 3 types of signaling proteins in the synovial membrane of rheumatoid arthritis patients
Time of Update: 2023-01-04
synovial tissue, human umbilical vein endothelial cells (HUVECs) and RA fibroblast-like synovial cells (FLS)of TCF-3, EBF-1, and HOXA5Results: Compared with IAR patients, mRNA expression of all 3 types of signaling proteins in the synovial membrane of RA was significantly reduced.
-
Guangzhou Health Center revealed the molecular mechanism of bacterial type VI. secretion effector protein RhsP targeting prey cells
Time of Update: 2022-12-30
Recently, the Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences and the University of Macau jointly published a report entitled Vibrio parahaemolyticus prey targeting require
-
Cardiovasc diabetol: Prospective association of circulating thromboreactive protein-2 levels
Time of Update: 2022-11-14
Due to the increased expression of TSP2 induced by hyperglycemia and its tissue expression in type 2 diabetes, a research article was published in Cardiovasc Diabetol, an authoritative journal in the field of cardiometabolic diseases, in which researchers analyzed the prospective association between circulating TSP2 levels and hospitalization for heart failure, and its association with longitudinal changes in echocardiographic parameters for type 2 diabetes.
-
Cell sub-issue: Protein profiles of 949 cancer cell lines across over 40 cancer types released
Time of Update: 2022-08-19
References: Introduction: Proteome research is a science that studies the composition and activity of proteins in cells, tissues and even the whole life at the overall level, so as to obtain an overall and comprehensive understanding of disease occurrence, cell metabolism and other processes at the protein level .
-
JCEM: Racial differences in the association of C-reactive protein with incidence of type 2 diabetes
Time of Update: 2022-03-04
Inflammation was associated with an increased risk of diabetes in both men and women , and black adults had significantly elevated inflammatory biomarkers, including C-reactive protein, compared with white adults .
-
Alz Res Therapy: a new type of cerebrospinal fluid protein that can effectively distinguish dementia from cognitive decline
Time of Update: 2021-11-11
Healthy control group, SCD, mild cognitive impairment (MCI), AD and non-AD dementia patients (cohort 2) .
-
CAR-T cells targeting intracellular proteins are expected to greatly expand the types of cancers that can be treated
Time of Update: 2021-11-11
Moreover, further studies have shown that even if the PHOX2B polypeptide is presented to the cell surface by different MHC types, this CAR-T cell therapy can recognize it .
bio/myrio-therapeutics-data-published-in-nature-unlocking-new- targets-for-antibody-based-therapies/[2] CHOP researchers develop a new class of CAR-T cells that target previously untargetable cancer drivers.
-
Lancet Diabetes Endo: The effect of dapagliflozin on urine protein in chronic kidney disease patients with type 2 diabetes
Time of Update: 2021-10-10
diabetesThe DAPA-CKD study is a multi-center, double-blind, placebo-controlled randomized trial conducted in 386 locations in 21 countries to evaluate the effect of dapagliflozin on proteinuria in patients with chronic kidney disease with type 2 diabetes Impact .
-
"Diabetologia" Intake of new whey protein before meals can improve blood sugar control in patients with type 2 diabetes
Time of Update: 2021-10-10
Whey protein microgel can reduce the spike in blood sugar after a meal and improve the body's insulin response (clearing glucose in the blood) .
-
Protein-regulated kainate-type glutamate receptor structure revealed
Time of Update: 2021-09-28
Photo courtesy of Nanjing UniversityThe structure of the desensitized GluK2-NETO2 complex .
In the paper of "Cryo-electron Microscope Structure of Receptors", the research team revealed the structural basis of NETO protein regulating the function of kainate-type glutamate receptors in the brain .
-
Injection of this small protein can protect type 1 diabetic cells
Time of Update: 2021-08-27
"The mitochondrial genome encodes previously unknown genes that produce small proteins with multiple physiological roles, including aging, exercise, metabolism, and immunity," Lee said .
Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune diabetes .
-
A major discovery: all cancer types can be divided into two types according to whether YAP protein is expressed or not
Time of Update: 2021-08-07
Some cancers such as prostate cancer and lung cancer can also transition from YAPon state to YAPoff state to resist treatment .
In general, this study shows that all cancers can be divided into two categories based on the presence or absence of YAP protein-YAPon cancer and YAPoff cancer .
-
Clinical Nutrition: Habitual intake of soy protein and isoflavones can reduce the risk of type 2 diabetes in women
Time of Update: 2021-03-21
Therefore, the researchers conducted a prospective study on the relationship between dietary soy protein and isoflavone intake and the risk of type 2 diabetes among Korean adults ≥40 years of age.
The association between soy protein and isoflavone intake is very obvious in women, but not in men.