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Chinese medicine, Acoladine, down-regulates the production and activation of hepatocarcinoma myeloid-derived immunosuppressive cells (MDSC)
Time of Update: 2021-03-24
These findings reveal that Akoladine reduces the production and activation of MDSC by down-regulating the extramedullary hematopoiesis of the spleen, which is one of its immunomodulatory and anti-tumor mechanisms.
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What are the focus of non-clinical research and evaluation of CDE's release of genetically modified cell therapy products?
Time of Update: 2021-03-24
Knowing that, this article interprets several related issues in the "Technical Guidelines for Non-clinical Research and Evaluation of Gene Modified Cell Therapy Products".
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Takeda will acquire Maverick Therapeutics to promote T-cell conjugation therapy for solid tumors and expand its new immuno-oncology product portfolio
Time of Update: 2021-03-19
com/ct/CT?id=smartlink&url=https%3A%2F%2F">TSE:4502/NYSE:TAK ) ("Takeda") today announced the exercise of its option to acquire a privately-owned biopharmaceutical company pioneering conditional active bispecific T cell targeted immunotherapy Maverick Therapeutics, Inc.
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/Insect Cell System: Adeno-Associated Virus-Based Products
Time of Update: 2021-02-22
The ability to make a large variety of virus-like particles (VLPs) has been successfully achieved in the baculovirus expression vector system (BEVS)/insect cell system.
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Europe's first! Novaral CAR-T cell product Kymriah was approved on the same day: ALL and DLBCL
Time of Update: 2021-02-14
In these trials, Kymriah showed strong and long-lasting response rates and consistent safety in two groups of patients who were difficult to treat.
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Uncovering the mature mechanisms for the production of NK cells promises to lead to the development of new immunotherapy for cancer and infectious diseases
Time of Update: 2021-02-12
researcher Ewa Sitnicka explains that without the Notch signaling path, NK cells would not mature properly and their numbers would decline, which is important for NK cells to fight cancer and infectious diseases effectively; (Bio Valley)
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In-body production of red blood cells helps solve the world's problems of blood shortage
Time of Update: 2021-02-11
the task force and cooperation team, research and establishment of a large number of extraterrocity of individual nuclear cells from human blood red system The experimental system of the ancestral cells and the efficient induction of differentiation
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Murray and Tencent have jointly developed AI products for blood cell analysis
Time of Update: 2021-02-11
to occupy more than 80% of the market share. blood cell counting products consist of blood cell analyzers, reagents, calibrations and quality control products. blood cell analyzer is one of the most widely used instruments in clinical
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In-body production of red blood cells helps solve the world's problems of blood shortage
Time of Update: 2021-02-10
to obtain large numbers of functional red blood cells through in-body culture is an important challenge in this field.
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Scientists have found that natural killer cells regulate anti-HIV antibody production
Time of Update: 2021-02-07
In developing a vaccine that stimulates an immune response to prevent HIV infection, researchers have been focusing on finding or producing a specific antibody that can mediat the virus. These broadly neutral antibodies (bnAbs) are eventually
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Production of SV40 Proteins in Insect Cells and In Vitro Packaging of Virions and Pseudovirions
Time of Update: 2021-01-31
The use of insect cells and lytic baculovirus for expression of biologically active mammalian proteins has been the method of choice of many investigators.
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Br J Cancer: Inhibiting CBX4 can effectively inhibit the production of sorafinia resistance in liver cancer cells
Time of Update: 2021-01-30
the study aims to explore the potential role of inhibiting CBX4-regulated cancer stem cells (CSCs) and to assess their contribution to Solafinib resistance in advanced liver cancer (HCC).
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Br J Cancer: Targeted cell autophagy improves the production of PARP inhibitor resistance in breast cancer treatment
Time of Update: 2021-01-30
in breast cancer patients with BRCA mutations, PARP inhibitors (PARPis) show potential single-drug anti-tumor efficacy.
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How to conduct non-clinical research on cloud-based cell therapy products?
Time of Update: 2021-01-21
, cell therapy products have their particularity, in the development process can not be carried out in full accordance with the idea of small molecular compounds, to the traditional non-clinical research methods put forward a huge challenge.
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Alkaloid Secondary Products from Catharanthus roseus Cell Suspension
Time of Update: 2021-01-15
However, it was soon found that plant cell cultures were often capable of producing compounds characteristic of the original plant.
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China's first autonomous CAR-T cell therapy products by CDE "breakthrough therapy drug" identified
Time of Update: 2021-01-02
to be formally incorporated into the "breakthrough treatment drug", adaptive to recurring or difficult acute lymphoblastic leukemia. , there is no CAR-T product approved worldwide for adult recurrence or resoicable acute lymphoblastic leukemia
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Measurement of Phosphoinositide 3-Kinase Products in Cultured Mammalian Cells by HPLC
Time of Update: 2021-01-02
The phosphoinositide 3-kinase (PI3K) family catalyses the addition of a phosphate group to the D-3 position of polyphosphoinositides (PPIn). Since the discovery in the late 80s that phosphatidylinositol is phosphorylated in the D-3
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Construction and Transfection of PCR Products Expressing siRNAs or shRNAs in Mammalian Cells
Time of Update: 2021-01-01
The siRNA expression constructs are constructed by PCR, and the PCR products are directly transfected into mammalian cells for functional testing.
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Card-mediated seedlings promote immune cell production
Time of Update: 2020-12-30
understanding the mechanisms behind this effect will support the prevention of neonatal sepsis with card-mediated seedlings," said Nelly Amenyogbe of the Telethon Children's Institute in Australia.
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Cell Stem Cell: Accident! Free fundamentals are good for the brain and can promote the production of new nerve cells by neural stem cells
Time of Update: 2020-12-18
team was able to confirm in mice that neural stem cells contained large amounts of free fundamentals compared to adult nerve cells.
