japonicum at the chromosome level and analyzed the genetic basis of the host adaptation of Schistosoma japonicum
Time of Update: 2022-05-20
>. The study used three-generation sequencing, Hi-C , full-length transcriptome ( Iso-Seq ) and other
The molecular mechanism of the chromatin remodeling complex regulating the higher-order structure of chromosomes
Time of Update: 2022-05-17
of nucleosomes and then affecting the binding of transcription factors to target genes . The chromatin of Arabidopsis also has higher-order structures similar to those of animals, such as chromatin regions
J Clin Oncol: Efficacy of blinatumomab-induced consolidation + POMP maintenance in elderly patients with Ph chromosome-negative B-ALL
Time of Update: 2022-03-05
blinatumomab was well tolerated and effective in the treatment of elderly patients with newly diagnosed Ph chromosome-negative B-ALL, including those at poor cytogenetic risk.
Magic 'switch' for mammals to sense chromosome number
Time of Update: 2022-01-26
"division of labor in spaceTo study the function of the new sequences, the scientists compared their activity in stem cells, developing cells, and cells with two or only one X chromosome .
information about the in vivo activity of artificial chromosomes
Time of Update: 2022-01-09
>Information storage artificial chromosomes (data-carrying chromosome, dChr) can be used for data storage in a stable and inexpensive way to replicate . However, the one-dimensional
Chromosome-level genome assembly of human fungal pathogens reveals collinearity between geographically different species
Time of Update: 2022-01-07
This study provides an important resource for fungal researchers and further emphasizes the importance of chromosome-level assembly in the analysis of high-throughput data sets .
Changes in DNA (inside and out of chromosomes) are driving factors for tumorigenesis and treatment resistance
Time of Update: 2021-12-25
Picture: Melanoma cell lines can carry BRAF gene amplification (red signal) in two significantly different modes, namely, extrachromosomal DNA (ecDNA) (left) and intrachromosomal uniformly stained region (HSR) (right) are inhibiting MAPK After drug resistance develops .
The first legume green manure crop chromosome level genome assembly is completed
Time of Update: 2021-12-02
This research fills the gap in the genomics research of legume green manure crops and provides new insights for the symbiosis of legumes and rhizobia .
FDA updates asciminib to treat Philadelphia chromosome-positive patients with chronic myeloid leukemia
Time of Update: 2021-11-15
of asciminib in CP Ph+ CML patients who have previously received ≥2 TKI treatments . A total of 233 patients were randomized (2:1) stratified according to the main cytogenetic response
Why cancer chromosome disorder can thrive
Time of Update: 2021-11-15
In this new study, Zanetti, Carter and colleagues analyzed 9375 human tumor samples and found that cancer cell aneuploidy preferentially intersects with certain branches of the stress response signal.
Published two "NAR" in a row, artificial chromosome research provides new ideas for gene therapy
Time of Update: 2021-11-03
These studies provide in-depth understanding of the mechanisms of DNA assembly and new centromere formation, and promote the cloning and gene therapy engineering of ACs .
Breaking the traditional view: connecting histones regulate the length and shape of chromosomes
Time of Update: 2021-10-20
Now, new research has determined a protein called junctional histone, which controls whether DNA is wound into long and thin chromosomes (consisting of many small loops) or short and thick chromosomes (consisting of fewer loops).
Supercomputer reveals how the X chromosome is folded and inactivated
Time of Update: 2021-10-19
"This is the first time we have been able to simulate all RNA that spreads around chromosomes and shuts them down," said a visiting scientist at Los Alamos National Laboratory, Massachusetts General Hospital and Harvard.
The Ji Kunmei/Chen Jiajie group of the Department of Medicine of Shenzhen University successfully mapped the chromosome level of the dust mite genome
Time of Update: 2021-10-10
College Hospital, and Li Jiang from Shenzhen Yima Biotechnology Company, adopted three sequencing technologies, including NGS, PacBio and Nanopore, and extracted the DNA of dust mite eggs. It minimized the contamination of the microbial genome
The relationship between chromosomal instability and senescence in Drosophila
Time of Update: 2021-09-19
the contribution of chromosomal instability and aging to cancer, and help identify possible treatments. Target . > Reversing the effects of chromosomal instability
New ideas for cancer therapy targeting mutant p53: consider the role of chromosomal changes
Time of Update: 2021-09-12
Now, researchers at Vanderbilt University Medical Center have discovered that in cells expressing mutant p53, aneuploidy drives the function to acquire a phenotype .
Telomere dysfunction and chromosomal instability in cancer cells
Time of Update: 2021-09-11
The authors found that treatment of cancer cells with Pt-cpym, Pt-vpym, Pt-ttpy or Pt-tpy will induce telomere dysfunction, leading to high chromosome instability .
What is the significance of the existence of the male Y chromosome?
Time of Update: 2021-09-03
if the genetic difference between the sexes is small, it can promote the evolution of the dimorphism of the sexes, so it can evolve within a few generations . >"Our experiments have shown
Chinese and foreign scholars PNAS cooperate to complete the maize B chromosome fine map and functional research
Time of Update: 2021-08-10
chromosomal variation materials, which were widely used in maize genetics, artificial chromosomes, gene dosage effects, and centromere studies . For example, it is found in corn that the inactivated B
Zhengkang revealed that dasatinib is more effective in treating children with Philadelphia chromosome-positive acute lymphoblastic leukemia
Time of Update: 2021-08-10
iNature requires a randomized clinical trial to determine whether the second-generation Abl-tyrosine kinase inhibitor dasatinib (dasatinib) is better than the first-generation inhibitor imatinib mesylate in the treatment of children with Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL) is more effective .