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Induction of IL19 expression through JNK and cGAS STING to regulate DNA damage-induced cytokine production
Time of Update: 2021-12-24
Stress produces cytokinesDNA damage, such as damage caused by ionizing radiation or inhibition of DNA replication checkpoint kinases, activates the cGAS-STING pathway and the transcription factor NF-κB, thereby triggering the secretion of pro-inflammatory cytokines, such as IL-1, IL-6 and IL- 8 .
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New study finds that extrachromosomal circular DNA regulates autosomal gene expression
Time of Update: 2021-04-17
The researchers used FISH experiments to verify the specificity of the interaction between ecDNA and its target region, and through in vitro circular DNA transformation experiments confirmed that ecDNA can indeed up-regulate the expression of autosomal genes.
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Use of DNA Microarrays to Study Global Patterns of Gene Expression
Time of Update: 2021-02-20
The images obtained are then analyzed by several software packages to identify and quantify the spots corresponding with the gene-specific probes.
After image processing, the data are normalized and then analyzed to determine those genes whose differential expression between the two samples is statistically significant.
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Real-Time Imaging of Gene Delivery and Expression with DNA Nanoparticle Technologies
Time of Update: 2020-12-23
The construction of safe, efficient, and modifiable syntheticDNA nanoparticles is an emerging technology that has achieved important milestones of success in the past 5 years.
A very important recent development in the study of DNA nanoparticles is the use of small-animal imaging.
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Transient and Stable Expression of Foreign DNA Introduced into Plant Protoplasts by Electroporation
Time of Update: 2020-11-07
Because of its general efficacy, electroporation is becoming a valuable technique for the introduction of DNA into cell types that are resistant to transformation by other procedures ( 6 - 8 ).
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The effect of Neanderthal DNA on gene expression in modern people.
Time of Update: 2020-09-12
," said Joshua Akey, a geneticist at the University of Washington and co-author of the paper, "and changes in the amount of those genes expressed further affect our esotexuality and susceptivity to disease." previous studies have shown that Neanderthal genes are associated with symptoms such as fat metabolism, depression and lupus.
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Promoting cell proliferation or inhibiting DNSMT1 expression can effectively induce passive DNA de methylation.
Time of Update: 2020-08-23
recently, Zheng Hui of the Guangzhou Institute of Biomedicine and Health of the Chinese Academy of Sciences discovered the new role of passive decethylation of DNA by studying the regulation of DNA methylation (methylation of cytosine) during cell proliferation.
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New discovery: Extra-chromosome DNA can express a large number of cancer-causing genes to promote rapid growth of cancer cells
Time of Update: 2020-06-07
Just a day later, a major study of ecDNA was published again in the leading academic journal, Cell This time, the scientists who led the study were from UCSD and Case Western Reserve University They f
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Classification of central nervous system tumors based on DNA methylation expression spectrum
Time of Update: 2020-06-03
Ref: Capper D, et al Nature. 2018 Mar 22;555 (7697):469-474 doi: 10.1038/nature26000 Epub 2018 Mar 14 But tumor methylation testing can reflect changes in DNA methylation and cell origin in somatic
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New findings: extracellular DNA can express carcinogenic genes in large quantities and promote the rapid growth of cancer cells
Time of Update: 2019-11-22
Yesterday, we reported a massive study in the journal Nature A team from Stanford University and the University of California, San Diego, found that extra chromosomal DNA (ecdna) can express a large n
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Studies have found that drinking alcohol during pregnancy may change the expression of fetal DNA
Time of Update: 2019-08-21
Recently, scientists from Rutgers University in the United States found that moderate to heavy drinking during pregnancy may change the expression of fetal DNA Relevant research is published in the in