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The Sci Transl Med Lanke/Xu Ke team traced the evolution of the virus lineage and proposed a new
Time of Update: 2023-02-03
The epidemic caused by the new coronavirus (SARS-CoV-2) is still ongoing, and so far more than 640 million people have been infected with the new coronavirus and more than 6. 6 million people have d
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The Transl Psychiatry-Suiqiang Zhu/Zhou Zhu team revealed that structural disconnection due to stroke predicts the risk of depression after stroke
Time of Update: 2023-01-06
Written by Pan Chensheng, Zhu ZhouResponsible editor—Wang Sizhen, Fang YiyiEditor—Summer LeafPost-stroke depression (PSD) occurs in about one-third of stroke people, and is associated with poor post-s
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The Transl Psychiatry-Suiqiang Zhu/Zhou Zhu team revealed that structural disconnection due to stroke predicts the risk of depression after stroke
Time of Update: 2023-01-06
Written by Pan Chensheng, Zhu ZhouResponsible editor—Wang Sizhen, Fang YiyiEditor—Summer LeafPost-stroke depression (PSD) occurs in about one-third of stroke people, and is associated with poor post-s
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Transl Res: Major advances in concomitant diagnostics with targeted drugs for lung cancer
Time of Update: 2023-01-04
Enrichment of EGFR Sub-Del library mutants and EGFR Ins-1 library variants for the cytotoxicity of five TKIsIn summary, the sensitivity of relevant mutations to five first-line EGFR-TKI-targeted drugs was evaluated by systematic drug sensitivity screening experiments for 7,4389 rare variants of EGFR gene in lung cancer.
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Clin Transl Immunol: Using cancer immunotherapy technology to develop immunotherapies with the potential to treat SARS-CoV-2 infection
Time of Update: 2023-01-01
Instead of having cells outside the body genetically engineered to kill infected cells, this ACE2-bispecific antibody therapy activates healthy T cells in the individual to target host cells that present the SARS-CoV-2 spike protein after infection.
com)Resources:Mikail Dogan et al.
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J Transl Med: High risk of melanoma polygenic is associated with improved patient survival in environments with high UV radiation
Time of Update: 2022-11-04
The results showed that in the meta-analysis of MIA and UKB, two loci were significantly associated with MSS, namely rs41309643 (G allele frequency 1.
The results showed that in the meta-analysis of MIA and UKB, two loci were significantly associated with MSS, namely rs41309643 (G allele frequency 1.
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Sci Transl Med: Niacin receptor HCAR2 regulates microglial response and AD progression
Time of Update: 2022-10-25
and activated HCAR2 using an FDA-approved niacin (Niaspan) preparation in 5xFAD mice, thereby reducing plaque load and neuronal dystrophy, reducing neuronal loss, and improving memory deficits, thereby mitigating amyloid-induced pathology, suggesting that the use of Niaspan may be a promising treatment for AD, specifically targeting neuroimmune responses.
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Transl Psychiatry—Yang Xun's team reveals the different neural mechanisms of schizophrenia in the reward expectation and reward outcome stages
Time of Update: 2022-10-25
On October 16, 2022, Yang Xun's team from the School of Public Administration of Chongqing University delivered a presentation at Translational Psychiatry "Neural substrates of reward anticipation and outcome in schizophrenia: a meta-analysis of fMRI findings in the monetary incentive delay task".
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Transl Oncol: Radiation therapy – light and darkness in the age of immunotherapy
Time of Update: 2022-10-25
Radiation therapy may effectively reduce the efficacy of immunotherapy by upregulating the infiltration of suppressive immune cells and directly damaging circulating lymphocytes, including CD8+ T cells.
Radiation therapy may effectively reduce the efficacy of immunotherapy by upregulating the infiltration of suppressive immune cells and directly damaging circulating lymphocytes, including CD8+ T cells.
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Transl Psychiatry—Accelerated aging of brain function in patients with major depression: evidence from large Chinese participants
Time of Update: 2022-10-14
The study found that patients with MDD had significantly higher Brain-PAD than the control group, a conclusion that was not affected by the age prediction algorithm.
The study found that patients with MDD had significantly higher Brain-PAD than the control group, a conclusion that was not affected by the age prediction algorithm.
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Transl Psychiatry: Physical activity partly mediates the link between cognitive function and depressive symptoms
Time of Update: 2022-10-12
Women under the age of 65 showed the highest overall effect of physical activity on depressive symptoms (total effect 1: B = -0.
Women under the age of 65 showed the highest overall effect of physical activity on depressive symptoms (total effect 1: B = -0.
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Transl Psych: Human preferences for alcohol and tobacco were inherited from Neanderthals, and this increased the risk of brain disease
Time of Update: 2022-10-12
For a long time, we know that human brain diseases such as nervous system diseases and mental diseases have the characteristics of family aggregation, which indicates that these diseases have a certai
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Transl Psychiatry—Early impairment of cortical circuit plasticity and connectivity in mouse models of Alzheimer's disease
Time of Update: 2022-10-02
In this study, the authors found that the expression of APP/PS1 mutants and the high Aβ load they produce can lead to disruption of early cortical plasticity development in the prefrontal cortex (PFC) and visual cortex (VC) of 5xFAD mice.
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Transl Psychiatry—Reticular meta-analysis: pharmacotherapy strategies for hyperprolactinemia caused by antipsychotics
Time of Update: 2022-10-02
Meta-analysis of randomized controlled trialsThe results showed that the combination of aripiprazole strategy was effective in reducing prolactin elevation due to antipsychotics (MD = -68.
Meta-analysis of randomized controlled trialsThe results showed that the combination of aripiprazole strategy was effective in reducing prolactin elevation due to antipsychotics (MD = -68.
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Ann Transl Med: analysis of m6A-related features associated with the tumor immune microenvironment and prediction of survival in acute myeloid leukemia
Time of Update: 2022-09-30
The research team built a prognostic model using m6A-related features associated with TIME to predict the survival of AML patients.
The research team built a prognostic model using m6A-related features associated with TIME to predict the survival of AML patients.