What is the key chemical transformation enabled by the new skeletal editing technique developed by University of Chicago researchers?

The new skeletal editing technique enables an oxygen-to-carbon swap, allowing chemists to convert easier-to-assemble isoxazole molecules into challenging pyrrole compounds.

Where and when was this skeletal editing work presented, and where was it formally published?

Abigail Bracken presented the work in a talk at the ACS Fall 2026 meeting on Tuesday morning in the Division of Organic Chemistry; coauthors Alexandra Lawrie and Isabella Romita reported on the study in poster presentations on Tuesday afternoon; the work was published in Nature the week before the meeting (DOI: 10.1038/s41586-026-10933-6).

Skeletal editing helps chemists access elusive pyrroles

Aug 25, 2026

University of Chicago researchers developed a novel skeletal editing technique to synthesize pyrrole compounds from isoxazoles, with findings published in Nature and presented at the ACS Fall 2026 meeting.

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Skeletal editing helps chemists access elusive pyrroles

Skeletal editing helps chemists access elusive pyrroles

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