STM poly (ADP-ribose) (PAR) may be a potential therapeutic target for frontotemporal dementia
Time of Update: 2022-11-26
Rothstein's team from the Mayo Clinic in the United States co-published a paper titled Science Translational Medicine Poly(ADP-ribose) promotes toxicity of C9ORF72 arginine-rich dipeptide repeat proteins, they demonstrate that PAR can induce R-DPR agglomeration and promote its induced SGs formation and TDP-43 aggregation, and that the absence of PAR can inhibit neurodegeneration。 Together, they identified PAR as a promoter of R-DPR toxicity that could serve as a potential target for the treatment of c9ALS/FTD.
2022CSH Professor Ma Jun: Inheriting the Century-old Torch, Innovating and Creating the Future: A Review and Prospect of the Development of Hematology in China
Time of Update: 2022-10-14
On September 23-25, 2022, the 17th National Hematology Academic Conference of the Chinese Medical Association was grandly opened at the National Exhibition and Convention Center in Shanghai. The confe
Brazil's first green hydrogen plant begins construction
Time of Update: 2022-09-26
The plant is expected to be put into operation by the end of 2023 and will be able to produce 10,000 tons of green hydrogen and 60,000 tons of green ammonia per year .
The innovation and quality of domestic drugs are being recognized by more and more overseas markets
Time of Update: 2022-09-21
【Pharmaceutical Network Industry Dynamics】In recent years, affected by the domestic generic drug market "inner volume" becomes the trend, innovation accelerates, and the stock market under medical insurance control fees begins to be compressed, a large number of pharmaceutical companies have begun to implement the internationalization strategy and accelerate the registration and listing of products overseas.
Advanced technology helps plastic packaging flexo to reach the top of the industry
Time of Update: 2022-08-24
". "Andrew Hewitson, co-founder and business development director of Reproflex 3, a British flexo printing company, believes that after more than ten years of technological innovation in plastic and paper packaging, flexo printing will eventually gain the recognition it deserves and will soon welcome Come to the spring of development and to the top of the industry .
These "high thermal conductivity graphite films" are very different
Time of Update: 2022-02-16
At present, the technical routes for preparing high thermal conductivity graphite films mainly include: expanded graphite calendering method, PI thin film carbonization-graphitization method, petroleum coke/coal pitch carbonization, highly oriented "pyrolytic graphite", etc.
Determination of trace sulfur in light olefins by oxidation microcoulometric method (3
Time of Update: 2022-01-06
First use a 10uL micro syringe to draw about 8uL of organic sulfur standard solution, dry the needle, and then slowly pull the needle core until the meniscus at the junction of the liquid and air is aligned with the 1uL scale, and note the position of the needle core end The reading (V1) .
Responding to the super "pig cycle": if the price of pigs cannot be controlled, then control the raising
Time of Update: 2021-11-15
mfa China Feed Industry Information Network-Based on feed, serving animal husbandry In the process of reducing costs and increasing efficiency, pig raising companies should review the current situation and continuously strengthen close cooperation with the emerging Internet and intelligent service industries to solve the "pig cycle" problem .
Hydroquinone for industrial use (4
Time of Update: 2021-10-31
Compare with the lead standard solution treated by the same method, do a limit test .
1mg/mL lead (Pb) standard solution with water before use .
Add 10ml sodium sulfide solution to each of the two colorimetric tubes, dilute to 50ml with water, and mix well .
Determination method of glucocorticoid drug residue analysis technology-capillary electrophoresis
Time of Update: 2021-09-20
Li Boxiang and others used reversed-phase pCEC-UVD technology to establish an efficient and simple GCs analysis method, which is suitable for the detection of GCs in hair .
China's second electronic chemicals zone was unveiled in Yichang and started construction
Time of Update: 2021-06-08
Among them, the opening day of Hubei electronic chemicals area, is the nation's first 2 Ge, Central Area 1 electronic chemicals area, Yichang is actively involved in the international integrated circuit break the blockade " strangle hold " problem of construction.
From drug-free to multiple treatments, 34 clinically urgently needed new drugs have been approved
Time of Update: 2021-03-08
statistics, NMPA has approved four clinically urgent need for new drugs for psoriasis, and the adaptations are moderate to severe plaque-like/type psoriasis.
addition, NMPA has approved a number of clinically urgent new drugs from abroad to bring innovative therapies to patients with multiple types of diseases.
Scale-Up of Oligonucleotide Synthesis: Solution Phase
Time of Update: 2021-03-06
At that time, their present-day competitor, the polymer support technique, was also developed and saw some first applications to oligonucleotide preparations ( 2 ), but it took nearly 15 further years until the solid-phase methods became a serious rival to solution methods.
16 DNA Analysis Under Highly Denaturing Conditions in Bare Fused Silica Capillaries
Time of Update: 2021-02-26
In the technique of single-strand conformation polymorphism (SSCP) analysis, completely denatured samples are loaded into a native sieving medium where ssDNA fragments adopt a conformation that is determined by their nucleotide sequence ( 6 , 7 ).
Triton X-100 nature and use precautions
Time of Update: 2020-10-24
3. Triton X-100 is often used with zwitterionic descaling agents such as CHAPS to purify membrane proteins so that membrane proteins maintain their natural appearance.
K remains active in solutions containing 1% Triton X-100.