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ACS catalyst: Zhang Junliang, Fudan University and Wu Haihong, Huashi University reported the palladium / WJ Phos catalyzed asymmetric Suzuki miyaara cross coupling reaction
Time of Update: 2020-01-26
(source: ACS catalyst.) Summary: the palladium catalyzed Suzuki miyaara cross coupling reaction has been developed by using WJ Phos as chiral ligand.
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JACS: light activated formaldehyde donor reveals the threshold of cell migration inhibition
Time of Update: 2020-01-24
Chemical tools that can monitor complex biological networks are a powerful means to evaluate biological signals
Formaldehyde (FA) is not only a byproduct of cell
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JACS: the E. J. Corey group of Harvard University synthesized chiral α - azido / α - aminoketone by racemic α - bromoketone
Time of Update: 2019-12-29
Recently, Corey group developed a method of enantioselective synthesis of chiral α - aminoketone by racemic α - bromoketone catalyzed by chiral quaternary ammonium salt, which was recently published in j.am.
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JACS of Newhouse group: Benzyl dehydrogenation of electron deficient Heterocyclic Aromatic Hydrocarbons Catalyzed by aryl nickel
Time of Update: 2019-12-25
Newhouse team reported the benzyl dehydrogenation of electron deficient Heterocyclic Aromatic Hydrocarbons Catalyzed by nickel, which uses ligands and oxidants to promote the β - hydrogen elimination process.
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91 year old Nobel Prize winner Professor Corey of Harvard University latest JACS synthesis of chiral α - aminoketone
Time of Update: 2019-12-18
When it comes to organic synthetic chemist E
J
Corey (Elias James Corey), perhaps the first thing you think about is "reverse synthetic analysis"
E
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Chem. SCI.: endoplasmic reticulum targeted fluorescence probe for zinc ion imaging
Time of Update: 2019-11-08
(source: Chemical Science) based on the good ER localization ability and Zn2 + response ability of probe 9, the author explored its imaging ability for endoplasmic reticulum stress induced by tunicamycin and Dauricine.
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Liang Yun, Professor of Hunan Normal University: palladium catalyzed synthesis of indole [2,1-a] isoquinoline
Time of Update: 2019-10-24
Lead indole [2,1-a] isoquinoline is a kind of polycyclic fused nitrogen heterocyclic compound, and it is also the structural unit of many bioactive molecules
Because
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ACS center. SCI.: fluorescent label with spontaneous scintillation mark designed for super-resolution imaging
Time of Update: 2019-10-17
(source: ACS Central Science) then, the author combined the structural modification methods of compounds 7 and 9 to obtain a new fluorescence group rhodamine hexafluoride 10 (Figure 4a).
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Angelw: the rycnovsky group of the University of California completed the asymmetric synthesis of (- - himeradine
Time of Update: 2019-10-08
rychnovsky group of University of California, Irvine completed the asymmetric synthesis of (- - himeradine a through the key cross ring Mannich reaction and rapid construction of quinazoline ring through 17 longest linear steps, which was recently published in angel.
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Angelw: synergistic therapy photocatalysis for singlet oxygen generation with activation of Pt (IV) prodrug
Time of Update: 2019-09-09
Int. ed.) in a word, based on Ru photosensitizer, the author developed a photocatalytic platform for activating Pt (IV) prodrug and producing singlet oxygen simultaneously.
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Professor Zhou Ling group of Northwest University: Series asymmetric PRINS reaction catalyzed by chiral phosphoric acid
Time of Update: 2019-09-02
Recently, a series of trans tetrahydropyrfuran tetrahydroquinoline derivatives have been synthesized for the first time by a series of asymmetric PRINS cyclization reaction based on the design of chiral phosphoric acid catalyst and substrate.
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Group of Conghuan, Institute of physics and chemistry, Chinese Academy of Sciences: the application of phosphine ligands derived from the framework of anthracene photodimers in palladium catalyzed coupling reaction
Time of Update: 2019-08-30
Recently, the research group of Conghuan, Institute of physics and chemistry, Chinese Academy of Sciences, has made new progress in the design of novel phosphine ligands for palladium catalyzed coupling reactions (org.
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Professor Xu Pengfei's research group of Lanzhou University: the introduction of axial chirality on the carbon ring of indole by using chiral hydrogen bond catalysis
Time of Update: 2019-07-26
2019, 21, 5219-5224), a new type of asymmetric catalyst with high catalytic activity, was synthesized on indole carbon ring by using chiral hydrogen bond catalysis for the first time.
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Wang Qingmin, Professor of Nankai University: light mediated Minisci C-H alkylation of non activated haloalkanes
Time of Update: 2018-12-06
However, the use of 5 mol% expensive Au photocatalyst and the use of high-energy UV lamp as the light source limited the functional group compatibility, substrate application and the application in drugs and natural products.
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Research group of Fu Junkai, associate professor of Northeast Normal University: the first realization of intermolecular heck coupling reaction between non activated alkenes and alkyl halides
Time of Update: 2018-12-03
Introduction heck coupling reaction is one of the important methods to construct carbon carbon bond
However, there are few reports on the intermolecular heck coupling
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Research team of Hu Xiaoke from Yantai Coastal Zone Institute of Chinese Academy of Sciences made progress in microbial degradation mechanism of nitroaromatic pollutants
Time of Update: 2018-09-11
Nitroaromatic compounds are a kind of important chemical raw materials, which are widely used in the production of medicine, pesticide, dye, pesticide and other chemical products
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Xie Jin and Zhu Chengjian of Nanjing University made important breakthrough in visible light catalysis
Time of Update: 2018-08-30
Author: Wang Dongping recently, Xie Jin group and Zhu Chengjian group of the research team of molecular and material synthesis, School of chemistry and chemical engineering
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Li Junlong, Sichuan Institute of antibiotic industry, Chengdu University: asymmetric cyclization of α - halogenated carbonyl compounds
Time of Update: 2018-08-30
Introduction in recent years, structural biology, molecular pharmacology, precision medicine and other related new disciplines have developed vigorously, providing new
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Ma Jun'an research group of Tianjin University: synthesis of difluoromethylpyrazoles with new difluoroalkyl diazo
Time of Update: 2018-08-06
On the basis of the previous work, the research team used thiophene and ethyl bromodifluoroacetate as starting materials to prepare a new difluoromethylation reagent, phenylsulfonyldifluoro diazoethane, through five steps reaction, and realized the efficient synthesis of difluoromethylpyrazoles.
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ACS catalyst: copper catalyzed radical mediated Suzuki miyaara coupling reaction
Time of Update: 2018-08-06
(source: ACS catalyst.) conclusion: Professor Takashi nishikata, Yamaguchi University, Japan, has developed a copper catalyzed Suzuki miyaara cross coupling reaction of tertiary alkyl bromide and alkenylborate.
