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Innovative gene therapies, ADCs... These four innovative drugs are expected to be approved by the FDA in November
Time of Update: 2022-11-04
According to PDUFA's expected target date, it is expected that in November, the US FDA will make a regulatory decision on the approval of 3 innovative drugs. If the approval process is faster, another
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Introduction of Cell Separation Technology Based on Cell Adhesion
Time of Update: 2022-08-30
Adhesion properties of cell culture vessels Oxidation Protein coating Coating with polylysineIsolation of Cells by Adhesion Properties Adherent Cultures Suspension Cultures Applications, Benefits and Limitations of Adhesion-Based Isolation Specific applications include:Digestion/decomposition of solid tissue Separation of plasma from blood to remove dead cells and debris type
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Application of real-time live cell analysis in hepatocellular carcinoma (HCC) research
Time of Update: 2022-08-30
Case Study Nature Inducing and exploiting vulnerabilities for the treatment of liver cancer Incucyte® Real-Time Live Cell Imaging System CDC7 is a target of senescence-inducing strategies in liver can
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【Science Sub-Journal】Single-cell sequencing for male infertility—optimizing circular sperm cell injection technology
Time of Update: 2022-08-20
This article is original from Translational Medicine Network, please indicate the source for reprinting Author: kopeIntroduction: Azoospermia is the main cause of male infertility, and its incidence i
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2022 Announcement of preliminary results of ASCO MEDI5752 monotherapy in advanced renal cell carcinoma
Time of Update: 2022-08-15
3% histologically clear cell carcinoma) received MEDI5752 (1500 mg) , intravenous injection every 3 weeks), 10 patients achieved objective remission (2 complete remission, 8 partial remission) In the EXP cohort, patients (none were immunotherapy-naïve, 63.
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APS: The antipsychotic penfluidol targets PFKL to inhibit the growth of esophageal cancer and may have broad antitumor effects
Time of Update: 2022-08-12
Mechanistically, the direct binding of penflulidol to PFKL inhibits the glycolysis of esophageal cancer cells and activates the AMPK/FOXO3a/BIM signaling pathway, thereby inhibiting tumorigenesis (Figure 3).
Mechanistically, the direct binding of penflulidol to PFKL inhibits the glycolysis of esophageal cancer cells and activates the AMPK/FOXO3a/BIM signaling pathway, thereby inhibiting tumorigenesis (Figure 3).
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"Magic medicine" becomes an ideal partner for cancer immunotherapy
Time of Update: 2022-08-12
Therefore, the results of this study suggest that the use of statins may contribute to the favorable prognosis of NSCLC patients receiving anti- PD-1 monotherapy , and statin therapy may be a combined tool for cancer immunotherapy in NSCLC patients .
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Identification of mint
Time of Update: 2022-06-19
The leaves are opposite, with short stalks; the leaves are shrunken and curled, and the intact ones are broadly lanceolate, oblong or ovate when flattened, 2～7cm long and 1～3cm wide; the upper surface is dark green, and the lower surface is gray-green , Sparsely hairy, with concave punctate adenoid scales .
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The latest research progress of six rare targets in lung cancer, one article inventory
Time of Update: 2022-04-27
Research progress in the treatment of rare gene mutations in non-small cell lung cancer [J].
[5]Zhou Jie. Research progress of NTRK gene fusion and TRK inhibitor in non-small cell lung cancer[J].
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Transformation and prognosis of nodular lymphocyte-predominant Hodgkin lymphoma: a Finnish national population-based study
Time of Update: 2022-03-09
Ilja Kalashnikov et al conducted a Finnish national population-based study to assess the risk and relative survival of transformation to large B-cell lymphoma in Finnish patients diagnosed with NLPHL from 1995 to 2018, comparing disease transformation with and without disease transformation mortality of patients .
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How far has medicine come in the tough road to protect pancreatic beta cells
Time of Update: 2022-01-26
Existing clinical research evidence shows that insulin as an early intensive treatment plan is more effective than traditional oral hypoglycemic drugs in improving islet β-cell function .
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Stroke prevention in high-risk patients with atrial fibrillation, left atrial appendage occlusion or NOAC? PRAGUE-17 study 4-year follow-up results announced
Time of Update: 2022-01-09
Conclusion The long-term follow-up results of the PRAGUE-17 study showed that for patients with nonvalvular atrial fibrillation at high risk of stroke and bleeding, cardiogenic thromboembolic events, cardiovascular deaths, clinically related bleeding, and surgical/device-related complications in the LAAC treatment group The composite endpoint is not inferior to the NOAC treatment group .
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JAAD: How to distinguish irritant seborrheic keratosis from squamous cell carcinoma
Time of Update: 2021-11-02
The main dermoscopic predictors of SCC are punctate blood vessels (odds ratio [OR], 10.
Heymann, Irritated seborrheic keratosis versus squamous cell carcinoma: Circling in on their differentiation, Journal of the American Academy of Dermatology,Volume 85, Issue 5,2021,Pages 1119-1120, ISSN 0190-9622, https: //doi.
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Express targeting CD4, legendary biological CAR-T therapy starts clinical trials in the United States
Time of Update: 2021-10-01
▎ WuXi AppTec content team editor September 13, 2021, Legend Biotech announced that based on the IND application approved by the US FDA, it will start a phase 1 clinical trial of the cell therapy LB1901 under investigation for the treatment of adult relapse/ Refractory peripheral T-cell lymphoma (PTCL), or cutaneous T-cell lymphoma (CTCL) .
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Mingzhao Zhu and Xiaoqun Wang's research team collaborated to identify the key vascular endothelial cells that regulate T cell thymic emigration
Time of Update: 2021-08-12
The researchers also further studied the developmental homeostasis of eTPEC and the cellular and molecular regulation mechanisms of mature T cell thymus emigration .
