Ai Beitai sincerely invites you to participate in the 7th EBC Bio-Industry Conference in 2022
Time of Update: 2022-08-30
In order to meet the needs of the rapid development of the biopharmaceutical industry, Ai Beitai also specializes in the development and production of disposable bioprocessing equipment and consumables .
Overcoming Barriers: How Rabbit Myxoma Virus Leaps into New Species
Time of Update: 2022-05-13
In a new study published in the journal mBio, Masmudur Rahman and his Arizona State University colleagues joined an international team of researchers to investigate one such spillover event, myxoma virus (MYXV) from Europe Rabbit crosses to the species of the Iberian hare .
"Building" a salt bridge to break the curse of "uncurable", the key target of the king of cancer
Time of Update: 2022-05-02
KRAS gene often 'untargetable'Zhang Yonghui, the corresponding author of the paper, said: "When we develop drugs, we will carefully observe the structure of the target protein and look for compounds that can bind to two key sites .
A new target for colorectal cancer immunotherapy: B7H3/B7H4
Time of Update: 2022-04-15
Because myeloid cells express a functional calcineurin NFAT axis that can be activated by Toll-like receptor agonists, the researchers explored the role of this pathway in intestinal tumor development .
Effective mixed backbone antisense oligonucleotides inhibit the expression of mutant C9orf72
Time of Update: 2022-01-10
Using C9-ALS/FTD patient-derived cells and C9ORF72 BAC transgenic mice, we generated and optimized antisense oligonucleotides (ASOs), which can selectively attenuate the expression of G4C2 repeat transcripts and effectively Inhibit the level of poly (GP) dipeptide in the tissue .
FDA blockbuster drug approval plan in October 2021
Time of Update: 2021-10-21
CompilenewbornAs of September this year, the US FDA has approved a total of 40 innovative drugs, compared with 40 in the same period last year and 53 in the whole year of last year .
Entering October, a number of drugs will usher in an important review decision by the FDA .
"Science": Innovative mRNA delivery technology is expected to bring changes to gene therapy
Time of Update: 2021-08-26
This pioneer in the CRISPR field worked with the team to develop a new mRNA delivery technology, which is expected to bring a disruptive change in the field of gene therapy!The inspiration for this breakthrough technology comes from the human body itself .
Roche's PD-1/LAG-3 bispecific antibody has been declared for clinical use in China, and is expected to be used for the treatment of metastatic melanoma, non-small cell lung cancer, esophageal squamous
Time of Update: 2021-08-01
gov website publicity information display, Roche is carrying out clinical trials to assess the safety and efficacy of RO7247669 indications covered include metastatic melanoma, non-small cell lung cancer, esophageal squamous cell carcinoma, advanced liver cancer and so on .
Innomicropharmaceuticals MVR-T3011 (intratumor injection) clinical phase II first case of drug delivery completed simultaneously in China and the United States
Time of Update: 2021-06-22
Innomicropharmaceuticals announced that its leading oncolytic virus product MVR-T3011 intratumoral injection (MVR-T3011 IT) phase II clinical study will be completed on May 28 and June 11, 2021, in China and the United States, respectively.
Strong combination | four-drug regimen D-KRd has significant efficacy in NDMM patients
Time of Update: 2021-05-22
The results of a prospective, randomized, phase III clinical study showed that the first-generation proteasome inhibitor bortezomib, lenalidomide, and dexamethasone were induced by a three-drug regimen (VRd) combined with ASCT in NDMM, and the median progression-free survival The period (PFS) is up to 50 months.
Simultaneous Detection of RNA and Proteins in Adenovirus-Infected Cells by Fluorescence In Situ Hybridization (FISH) and lmmunostaining
Time of Update: 2021-02-17
Adenovirus (Ad)-infected cells have been used extensively as a model system for studying the expression of eukaryotic genes and were instrumental in elucidating steps m the production of RNA.
Much of this work involved genetic and molecular analyses of viral gene expression.
The Analysis of Innate Immune Response to Adenovirus Using Antibody Arrays
Time of Update: 2021-02-16
In animal models, intravenous Ad administration has been shown to induce transcription and release in the serum of a great number of pro-inflammatory cytokines and chemokines.
Adenovirus Capsid Chimeras: Fiber Terminal Exon Insertions/Gene Replacements in the Major Late Transcription Unit
Time of Update: 2021-02-14
The capsid proteins hexon, penton, and fiber contribute to efficient infection by adenovirus, and each contributes in some manner to the antiviral immune response against adenovirus infection.
In this chapter, we are presenting a terminal exon-replacement strategy that can be used to genetically manipulate capsid proteins expressed from the MLTU.
A treatment that reduced bad cholesterol by 61% In animal experiments with gene editing therapy showed lasting results
Time of Update: 2021-01-22
previous studies have shown that PCSK9 gene infestion can increase LDL-patient expression, leading to lower LDL-C levels and reducing the risk of coronary heart disease.
the average blood PCSK9 protein level decreased by 89% over the same six-month period.
Autism is associated with specific brain cell abnormalities
Time of Update: 2020-12-26
U.S. researchers found that in the brains of children and young people with autism, several specific types of nerve cell gene expression abnormalities affect neuron growth and communication with each other, and that the extent of some gene expression abnormalities is associated with the severity of the condition.