Neuron: Drosophila helps identify human neuroprotective genetic programs
Time of Update: 2021-08-27
Dietmar Schmucker, a Humboldt professor at the Institute of Life and Medical Sciences at the University of Bonn and the co-corresponding author of the study, said: “We specifically turned off individual genes and observed how neurons change .
Scientists have discovered new characteristics that distinguish modern people from Neanderthals
Time of Update: 2021-08-11
The team found that the modern human genome has undergone mutations, which reduces the stability of adenylate succinate lyase, resulting in a decrease in purine synthesis .
Nature Cell Biology: Golgi-derived vesicles regulate the division of endosomes
Time of Update: 2021-08-07
with electron microscopy to identify a vesicle derived from the Golgi apparatus and highly expressing SEC14L2, named SEC14L2 vesicle . When the chemical inhibitor BFA is used to treat cells
How small bee mites affect the behavior of western bees
Time of Update: 2021-08-01
Photo courtesy of the Institute of Bees, Chinese Academy of Agricultural Sciences The parasitic mites of May's heat mite significantly reduced the ability of flying homing and olfactory learning and memory of bees.
A new evolutionary mechanism for the accumulation of beneficial mutations in vegetative fungi revealed
Time of Update: 2021-08-01
Photo courtesy of the Institute of Plant Protection, Chinese Academy of Agricultural Sciences Beneficial mutation mechanism of Verticillium dahliae accumulation in agricultural ecosystems .
Grapefruit + lipid-lowering drugs eat "myolysis
Time of Update: 2021-07-25
Liu, 58 years old in Wuhan, ate some grapefruit while taking the lipid-lowering drug atorvastatin, which caused "rhabdomyolysis syndrome .
Clinical trial of Taletrectinib in the treatment of NTRK fusion solid tumors completed the first patient administration
Time of Update: 2021-06-28
Innovent announced today that the second phase basket trial of taletrectinib in the treatment of NTRK fusion solid tumors has completed the first patient administration (NCT04617054) .
This gene allows rice to "eat less" nitrogen and produce more rice
Time of Update: 2021-06-28
Photo courtesy of the Chinese Academy of Agricultural SciencesSBM1 negatively regulates rice plant height, grain number per panicle, biomass and yield.
Cell Death Differ: MLKL-mediated G-CSF release promotes myeloid differentiation in acute myeloid leukemia
Time of Update: 2021-06-16
MLKL can regulate myeloid differentiation in AML by mediating the release of G-CSF from leukemia progenitor cells .
Neuron | Mei Lin/Xiong Wencheng's group reveals a new mechanism of postsynaptic receptor aggregation and neuromuscular junction formation
Time of Update: 2021-06-01
Editor | xi Every activity in our daily life, such as walking, eating, drinking, breathing, and even sitting still
Immunity: Xiao Yichuan's team and others reveal new DNA sensing pathways in CD4+ T cells and their regulatory mechanisms that mediate aging-related autoimmune diseases
Time of Update: 2021-03-23
Therefore, the activation of the DNA sensing pathway mediated by the KU complex in CD4+ T cells is a key mechanism leading to the occurrence and development of autoimmune inflammation in aged mice.
Idea Di Pharmaceutical 3D011 has been approved for clinical use in advanced solid tumors
Time of Update: 2021-03-12
, the Research and Development Team of Mindy Pharmaceuticals decided to improve its pharmacological dynamics through pre-drug design, thereby reducing its systemic toxicity.
Measurement of Plant Cyclin-Dependent Kinase Activity Using Immunoprecipitation-Coupled and Affinity Purification-Based Kinase Assays and the Baculovirus Expression System
Time of Update: 2021-03-11
Orderly progression of the eukaryotic cell cycle is governed by a coordinated response to intrinsic and extracellular cues through activation of cyclin-dependent kinases (CDKs).
A uniform procedure for the purification of CDK7/CycH/MAT1, CDK8/CycC and CDK9/CycT1
Time of Update: 2021-03-06
Our protocol provides a novel systematic approach for the purification of these three (and possibly other) recombinant CDKs.
17-year-old Biono award winner Rosbash's Scientific Reports paper
Time of Update: 2021-03-05
biological clock is one of many fascinating mysteries that can be found in life. This year's Nobel Prize in Physiology and Medicine went to three geneticists who study biological clocks, including Nobel Laureate Michael Rosbash, who published
Insulin enhances mosquitoes' immunity to the yellow virus
Time of Update: 2021-03-02
virus, dengue virus and Zika virus. Researchers say the findings could help develop interventions to reduce mosquito-borne infections. West Nile virus, dengue virus and Zika virus are representative viruses of the yellow virus genus. West Nile
Probing the Telomere Damage Response
Time of Update: 2021-02-28
Telomere dysfunctions, rendered through replicative attrition of telomericDNA or due to the inhibition of shelterin components, are recognized as DNA double-stranded breaks (DSBs) by the DNA damage repair (DDR) pathway
New genes to fight rice pestilence are cloned
Time of Update: 2021-02-27
23rd, Cell Research published online the latest advances in the molecular mechanism of rice resistance to rice pestilence by Wan Jianmin, a member of the Chinese Academy of Engineering. They cloned OsCNGC9, a new gene that regulates
A Computational Method to Search for DNA Structural Motifs in Functional Genomic Elements
Time of Update: 2021-02-24
The rapidly increasing availability ofDNA sequence data from modern high-throughput experimental techniques has created the need for computational algorithms to aid in motif discovery in genomic DNA. Such algorithms
Lilly and Rigel have authorized a $960 million partnership to develop RIPK1 inhibitors to treat autoimmune and inflammatory diseases
Time of Update: 2021-02-23
cooperation agreement, Lilly will also lead the clinical development of brain-penetrating RIPK1 inhibitors in all central nervous system (CNS) diseases.