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New NBT cell therapy strategies protect patients from antibody-mediated rejection
Time of Update: 2023-02-01
In the next step, human CD64 was overexpressed in B6 B2m−/−Ciita−/−Cd47+ immunocompromisedCd64CD64−−/−+(HIP)[2]iECsCD64, B6 HIP iECs CD64 showed IgG1 Fc capture ability in a concentration-dependent manner, and subcutaneous transplantation experiments in ADCC model Rag-1-deficient mice also confirmedCD64 ability to capture Fc. Cd64-expressing mouse iECs were indeed able to protect against antibody-mediated killing effects.
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Transl Res: Major advances in concomitant diagnostics with targeted drugs for lung cancer: a systematic assessment of the sensitivity of 74,389 rare EGFR mutations to 5 first-line targeted inhibitors
Time of Update: 2023-01-04
Enrichment of EGFR Sub-Del library mutants and EGFR Ins-1 library variants for the cytotoxicity of five TKIsIn summary, the sensitivity of relevant mutations to five first-line EGFR-TKI-targeted drugs was evaluated by systematic drug sensitivity screening experiments for 7,4389 rare variants of EGFR gene in lung cancer.
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The European Union is developing new batteries based on graphene
Time of Update: 2022-11-20
Graphene It is reported that perovskite photovoltaic cells with graphene are the core topic of Working Group Nine.
Graphene It is reported that perovskite photovoltaic cells with graphene are the core topic of Working Group Nine.
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Peking University Nature Publishes Breakthrough Research Achievement: Artificial Intelligence Assists Time-Resolved Cryo-EM to Discover Dynamic Regulation Mechanisms of Major Drug Targets
Time of Update: 2022-05-12
Molecular machines of life achieve their special functions through highly complex non-equilibrium kinetic processes and structural changes, which are then precisely regulated by various complex interm
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Which innovative drugs/therapies will bring us surprises and hopes in 2021
Time of Update: 2021-12-30
With the construction of these platforms, the technical level and standardization of domestic innovative drug research and development have also been improved, and new innovations have continued to emerge .
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Eliminate cancer cells by changing their identity
Time of Update: 2021-12-29
"Now, Blanco and his colleagues have discovered a new way to trigger the differentiation of AML-one and potentially treat a wider range of AML patients, according to the team published their research (“KAT6A ENL forms an epigenetic transcription control module Drive the key gene expression program that causes leukemia") in the discovery of cancer .
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Early stages of human development can be "perspected
Time of Update: 2021-12-01
People's current understanding of the formation of human gastrulation is basically limited to experimental models, and it is impossible to directly conduct research on it, because human embryos at this stage are difficult to obtain.
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Science new mechanism of muscle regeneration
Time of Update: 2021-11-02
The lead author of the study, iMM and UPF researcher William Roman explained: "Even under physiological conditions, regeneration is essential for muscles to withstand the mechanical stress of contraction, which often leads to cell damage .
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The "double-edged sword" of Dev Cell neurons—Xiao Bo's team reveals a new mechanism by which lactic acid induces peripheral nerve damage
Time of Update: 2021-10-22
On October 6, 2021, a research team led by Professor Xiao Bo from the School of Life Sciences of Southern University of Science and Technology published an article Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability in the Journal of Developmental Cell, and found that peripheral glial cells-Schwann The pyruvate-lactic acid conversion metabolism regulated by Rheb in cells is very important for maintaining the stability of axons in the peripheral nervous system .
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"Science" The inner workings of the membraneless cell compartment
Time of Update: 2021-09-19
The researchers say that their work can promote scientific understanding of cell evolution and help scientists in the food and chemical industries develop better ways to prevent the separation of liquid mixtures .
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The team of academician Gao Fu proposes a new strategy for safe and effective Zika vaccine
Time of Update: 2021-08-08
The rational design of the ADE antibody based on the structure of the FL epitope-targeted antigen shows that the MutB/C vaccine can produce a clear immune response in a single immunization, which completely protects the mice against the Zika virus challenge, in all cases of viral infection No viral load was detected in the target tissues .
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Johnson & Johnson Imbruvica combined with Roche Venclexta successfully treats CLL/SLL Phase III clinical trial
Time of Update: 2021-06-21
The study conducted by Johnson & Johnson subsidiary Janssen compared Imbruvica+Venclexta combination therapy with chlorambucil + obinutuzumab (Clb+O) in this patient population .
The data shows that oral Imbruvica + Venclexta shows superior progression-free survival (PFS) compared to other combined infusion regimens .
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Blood: Long-term prognosis after gene therapy for patients with adenosine deaminase severe combined immunodeficiency (ADA SCID
Time of Update: 2021-06-21
Patients who lack functional adenosine deaminase activity will develop severe combined immunodeficiency (ADA SCID) and can be treated with ADA enzyme replacement therapy (ERT), allogeneic hematopoietic stem cell transplantation (HSCT) or autologous HSCT with genetically corrected cells ( Gene Therapy-GT) Treatment of ImmunityA cohort of 10 ADA SCID patients aged 3 months to 15 years old received GT treatment in a phase II clinical trial from 2009 to 2012 .
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Nat Neurosci︱ For the first time! Neuron ApoE affects the new mechanism of AD pathology by affecting immune response genes
Time of Update: 2021-06-02
(2021) ) Nat Neurosci) Article conclusions and discussion In general, first, this study proposes a new model, that is, during the aging process, the increase of ApoE expression in neurons acts as a molecular switch that can trigger the immune response pathway in neurons The abnormal up-regulation of related gene MHC-I drives tau pathology and selective neurodegeneration in synapses and neurons.
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Interpretation of the 2021 CSCO Guidelines for Composite SCLC and Transformational SCLC Guidelines
Time of Update: 2021-05-09
The guidelines for complex small cell lung cancer recommend interpretation of the treatment of C-SCLC so far, there is still a lack of large-sample prospective randomized controlled clinical research data, most of which are small-sample retrospective analysis and case reports.
What is recommended by the compound SCLC guidelines as transforming small cell lung cancer?
