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Nature: Whether previous infection with SARS-CoV-2 alters the body's immune response to other threats depends on the sex of the body
Time of Update: 2023-02-02
Tsang thinks the findings could also help scientists develop better vaccines to deal with different threats, such as simulating how mild COVID-19 can alter men's immune baselines.
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2022 PANCCO Guidelines: Treatment Essentials for Ulcerative Colitis in Adults (Part I
Time of Update: 2023-01-06
(Recommended level: strong; Quality of evidence: very low)Recommendation 6: Equivalent doses of oral mesalazine or sulfasalazine are recommended for induction of clinical remission in patients with mildly to moderately active left or extensively diseased UC.
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2022 PANCCO Guidelines: Treatment Essentials for Ulcerative Colitis in Adults (Part I
Time of Update: 2023-01-06
(Recommended level: strong; Quality of evidence: very low)Recommendation 6: Equivalent doses of oral mesalazine or sulfasalazine are recommended for induction of clinical remission in patients with mildly to moderately active left or extensively diseased UC.
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Southern Medical University has made progress in the research on the mechanism of enterogenic lung injury
Time of Update: 2022-10-31
Fig. The intestinal flora metabolite succinic acid acts on its receptor SUCNR1 to promote the M1 polarization of alveolar macrophages and aggravates acute lung injury after intestinal ischemia and reperfusion With the support of the National Natural Science Foundation of China (grant numbers: 81730058, 82172141, 82002088), Professor Liu Kexuan's team at Southern Medical University has made progress in the study of the mechanism of intestinal lung injury, and the research results are "Gut microbiota-derived succinate aggravatesacute lung.
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Sun Yat-Sen University: How does the microbiota metabolite IPA inhibit atherosclerosis
Time of Update: 2022-08-15
321253 In a recent study published by his team in Circulation Research, it was found that the gut microbiota metabolite indole-3-propionic acid (IPA) can promote cholesterol reversion in macrophages through the miR-142-5p/ABCA1 axis in humans and mice Therefore, it has a protective effect on atherosclerotic cardiovascular disease (ASCVD) and provides a new potential intervention target for improving ASCVD .
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How to choose imipenem, meropenem, biapenem and ertapenem
Time of Update: 2022-01-24
Imipenem, meropenem, biapenem, and ertapenem are four carbapenem antibiotics commonly used in clinic.
1 There are four carbapenem antibiotics included in the 2020 medical insurance list: imipenem, cilastatin, meropenem, biapenem, and ertapenem .
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Gut: Multi-omics reveals the unique characteristics of epidermal adipose tissue related to systemic insulin resistance
Time of Update: 2021-10-10
It can be seen that the multi-omics epiAT feature reflects a systemic IR and obesity subphenotype that is different from other fat depots .
The multi-omics epiAT feature reflects a systemic IR and obesity subphenotype that is different from other fat depots .
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Science: "Detergent" widely present in cells
Time of Update: 2021-07-29
Although scientists know that cells can attack bacterial membranes, this study reveals the first example of a protective intracellular protein that acts like a detergent .
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These new antibiotics can treat community-based pneumonia
Time of Update: 2021-03-23
Clinicians should also be aware that patients with pneumonia admitted to the hospital may have specific risk factors (recent intravenous antibiotics, admission from a long-term care facility) that make them susceptible to bacterial pathogens in the hospital, including Pseudomonas aeruginosa and methicillin-resistant gold Staphylococcus aureus, although these patients come from outside the hospital, there has been controversy regarding classification, empiric therapy, and frequent failure of initial antibacterial therapy.
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Vaccines - a never-out-of-time "golden good
Time of Update: 2021-03-09
our bodies recognize that the protein should not exist and produce T lymphocytes and B lymphocytes, which remember how to fight the virus that causes COVID-19 if we are infected in the future.
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Scientific research has found that the human bacteria are also divided between men and women
Time of Update: 2021-03-01
Recently, a study Kunming Animal Research Institute in China revealed the gender differences in the bacteria.
study showed that men and women differ in their susceptibleness to certain diseases, including obesity, diabetes, gyringe, autism, depression, and so on.
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Identification of Novel Pathogenicity Genes by PCR Signature-Tagged Mutagenesis and Related Technologies
Time of Update: 2021-02-17
This is a PCR-based STM mutation-based screening method using a population of bacterial mutants for the simultaneous identification of multiple virulence genes in microbial pathogens by negative selection.
PCR-based STM represent a genomics-based method for in vivo high-throughput screening of new virulence factors.
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Probiotics regulate gut microorganisms to relieve mental anxiety during crew sailing
Time of Update: 2021-02-10
The results showed that after the voyage, 42 seafarers who took placebo had intestinal bacteri group disorders, increased levels of pathogenic bacteria (Gordon's Streptococcus and Pneumonia Kreber), and the crew's psychological stress and mental anxiety were at risk.
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J Infect Chemother: Epidemiological and risk factors for CRE-induced neurosurgery bacterial meningitis/encephalitis
Time of Update: 2020-12-22
, a single-variable analysis showed that the risk factors for CRE meningitis were ventilators, bacteremia, hospitalization in the intensive care unit (ICU), hospital-based pneumonia, and death from infection.
multivariative analysis shows that hospital-based pneumonia and infection-caused deaths are independent risk factors for CRE meningitis.
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New antibiotics have shown great therapeutic potential in the Study of Thyrobacter Difficile II
Time of Update: 2020-11-25
Acurx Pharmaceuticals recently announced positive results in a phase II clinical trial of a new antibiotic, a DNA polymerase IIIC inhibitor called ibezapolstat, used to treat CDI (Difficult Thoresium infection).
