Lancet Neurol: Plasma phosphorylated tau 217 and phosphorylated tau 181 as biomarkers for Alzheimer's disease and frontotemporal degeneration
Time of Update: 2021-11-01
Plasma tau protein phosphorylation at threonine 217 (p-tau217) and plasma tau protein phosphorylation at threonine 181 (p-tau181) are related to the tau pathology of Alzheimer's disease . Recently,
Diagnosis of Krabbe Disease by Use of a Natural Substrate
Time of Update: 2021-02-27
Because of its low abundance this enzyme is difficult to assay in certain situations, such as prenatal diagnosis by chorionic villus sampling.
To obviate this a modified assay is used where only the radiolabeled substrate is included in the incubation.
Assay of Antibacterial Activities of the Bactericidal/Permeability-Increasing Protein in Natural Biological Fluids
Time of Update: 2021-02-01
This process is driven by microbe-specific signals, including highly conserved and chemically unique microbial (envelope) components, such as Gram-negative bacterial lipopolysaccharides (LPS) ( 1 , 2 ).
Determination of Ornithine Decarboxylase Activity Using [3H]Omithine
Time of Update: 2021-01-02
This reaction is the rate-limiting step in the biosynthesis of the naturally occurring polyamines, which regulate proliferation and which are closely linked to neoplastic growth.
Because of the central role played by ODC in various biological systems, attempts have been made to develop sensitive, specific, and simple methods for its assay.
Assay for Isolation of Inhibitors of Her2-Kinase Expression
Time of Update: 2020-12-20
Her2 (ErbB2) protein is overexpressed in breast and other solid tumors, and its expression is associated with progressive disease.
However, little is known about alternative mechanisms for suppressing Her2 expression, possibly by inducing degradation or blocking synthesis.
The structure and function of several important types of protein molecules mediated by single trans-membrane conductor signal transductivity
Time of Update: 2020-10-26
In unstilled cells, MAPK is stationary, and when it receives the phosphatation regulatory signal of the upstream molecule MAPKK (MAp Kinase Kinase), the adjacent suline and tyrosine in mapK are phosphatized, thus becoming the active form of MAPK.