Science sub-journal: Unlocking a new strategy for in vivo editing of CAR-M for post-operative immunotherapy of glioma
Time of Update: 2022-08-20
▲Research ideas for "local" MΦ in situ CAR structure editing around the tumor cavity after surgery and its targeted clearance of GSCs Image source: ReferencesIt is worth mentioning that the researchers published a related research paper entitled: "Intracavity generation of glioma stem cell-specific CAR macrophages primes locoregional immunity for postoperative glioblastoma therapy" in Science Translational Medicine on August 3 .
Time of Update: 2022-08-19
The related research results were recently published in the Journal for ImmunoTherapy of Cancer with the title "Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment" .
Fetal exposure to drugs may affect baby's brain development
Time of Update: 2022-05-26
In utero exposure to maternal antiepileptic or antidepressant drugs may affect the development of brain networks in newborns, new research suggests .
Disintegrate tumors with sonic waves
Time of Update: 2022-05-19
▲ After using the new technology, the tumor volume decreases rapidly, and there is basically no recurrence (Image source: Reference )Eighty percent of the rats treated with ultrasound showed no recurrence or metastasis .
Moderna's new paper: mRNA encoding monoclonal antibody against Chikungunya virus
Time of Update: 2022-01-10
As early as May 2019 before the outbreak of the new crown epidemic, Moderna had published a pre-clinical research paper in Science Immunology , using lipid nanoparticles (LNP) to deliver the light chain of the encoding human monoclonal antibody (CHKV-24 IgG) And heavy chain mRNA, targeting the E2 glycoprotein of Chikungunya virus, can protect mice infected with Chikungunya virus from arthritis, musculoskeletal diseases and fatal attacks.
Siddi declares CD47 monoclonal antibody
Time of Update: 2021-12-09
On November 2nd, CDE accepted the clinical trial application for the CD47 monoclonal antibody drug 3D197 .
This application is the first phase I clinical trial of 3D197 in China.
Summary of NMPA's new anti-tumor drugs approved in June, domestic drugs ushered in a small outbreak
Time of Update: 2021-07-29
Drug name: Vidicuzumab (trade name: Aidixi, research code: RC48) R&D company: Rongchang Biological Indications: Gastric cancer (including adenocarcinoma of the gastroesophageal junction) On June 9th, NMPA announced that it had passed the priority review and approval procedure and conditionally approved the listing of Rongchang Bioinjection Vidicuzumab (trade name: Aidixi), which is suitable for HER2 patients who have received at least 2 types of systemic chemotherapy.
Science journal: Antisense oligonucleotides are expected to treat MECP2 duplication syndrome
Time of Update: 2021-03-22
Researchers from Baylor College of Medicine in the United States have previously found that antisense oligonucleotide (ASO) therapy can reduce the level of MeCP2 protein in a mouse model of MDS and reverse its disease characteristics.
Marine animal chrysanthemums have been found for the first time in amber
Time of Update: 2021-03-15
The team used high-resolution microscopic fault scanning technology (microCT) to analyze the chrysanthemum in the amber, indicating that the chrysanthemum was a larvae specimen belonging to the Puzosia subs genus.
Nature sub-journal paper details! CAR-T cells targeting CXCR5 are expected to treat feliestic lymphoma and chronic lymphocytic leukemia
Time of Update: 2021-01-27
In the new study, a team led by Dr. Uta Hoepken, head of the Autoimmune and Tumor Microenvironigning Laboratory at Max Delbrook Molecular Medical Center, developed a new form of therapy that allows T-cells in the lab to be sensitive to different identification characteristics--- the B-cell home protein CXCR5.
Early breast cancer is enough to target radiotherapy once
Time of Update: 2020-11-17
Recently, the long-term results of the TARGIT-A trial, published in the British Medical Journal (BMJ), showed that for early breast cancer patients, single-dose targeted radiotherapy during excision had a similar effect to postoperative full-breast radiotherapy, and reduced non-breast cancer mortality.
Study on the parameters of UV curing coating curing process
Time of Update: 2020-10-07
Abstract: This paper studies the relationship between UV curing process parameters and coating performance, and the experiment shows that coating thickness affects the hardness, adhesion, flexibility and wear resistance of the coating, and the UV curing light source and manufacturing environment also have a great influence on the coating material performance.
Brain, Behavior, and Immunity: Chronic pain is inextricably linked to the immune system
Time of Update: 2020-06-22
Introduction: There are three main types of pain: first, injury pain, from bee bruises, ankle sprains to inflammatory arthritis; pain happens from time to time in our lives, so we think of it as a
FDA requests that the bodyguard material be withdrawn from the market automatically belviq
Time of Update: 2020-02-14
Today, the FDA issued a drug safety notice, requiring Weicai to automatically withdraw its weight-loss drugs belviq and belviq XR (commonly known as Lorcaserin) FDA analyzed a 12000 person cardiovascu
The latest research reveals a new method of antibody drug targeting damaged heart
Time of Update: 2020-02-07
A study from the University of North Carolina and the University of North Carolina, Chapel Hill, reported a new type of platelet particle that can target anti-inflammatory drugs to the ischemic heart