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The future can be expected - "Late Non-small Cell Lung Cancer Anti-angiogenesis Drug Treatment Chinese Expert Consensus (2022 Edition)" officially released
Time of Update: 2022-10-12
The "Consensus" is based on the 2020 edition, revised by the expert group based on the new evidence published in recent years, combined with clinical experience, to guide the rational use of anti-angiogenesis drugs in the clinical departments of lung cancer treatment in China, and further improve the standardized diagnosis and treatment level of lung cancer in China.
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Neurology: Application of MRI metabolomics in idiopathic intracranial hypertension to identify markers of disease and headache
Time of Update: 2022-10-02
Using proton magnetic resonance spectroscopy, they used non-targeted metabolomics methods to determine quantitative differences in metabolites in CSF, serum, and urine in active IIH participants, and compared them with control groups that matched age, sex, and body mass index (BMI).
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Micro-classroom No. 10 Professor Jin Fengyan: Progress in the evaluation of debilitating elderly multiple myeloma
Time of Update: 2022-09-21
Multiple myeloma (MM) is a malignant disease of abnormal proliferation of cloned plasma cells, which is the second most common malignancy in the blood system in many countries, and is more common in o
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JHO (IF=23) In a multi-unit collaboration with Xiamen University, Xu Bing/Li Zhiming/He Xuhua revealed the evolution of the tumor immune microenvironment in follicular lymphoma patients over a 24
Time of Update: 2022-09-21
Patients with follicular lymphoma have a poor prognosis if they experience disease progression (POD24) within 24 months.
Patients with follicular lymphoma have a poor prognosis if they experience disease progression (POD24) within 24 months.
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STAT3 protein degraders exhibit anticancer activity by increasing tumor sensitivity to PD-1 inhibitors
Time of Update: 2022-02-25
▲KTX-201 changes the tumor microenvironment (Image source: Kymera official website)Moreover, when KTX-201 was combined with an anti-PD-1 antibody, it resulted in a 60% complete remission in a mouse model of solid tumors, and the animals gained immune memory and the growth of re-implanted tumors was inhibited .
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JCEM: Systemic inflammation mediates the link between obesity and severe COVID-19 outcomes
Time of Update: 2021-09-12
The results of this study support the systemic inflammatory pathway of obesity-related severe COVID-19 disease, especially in patients under 65 years old, which is mediated by CRP and ESR .
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Nat Aging: Large-scale plasma proteome analysis to identify risk proteins related to dementia
Time of Update: 2021-06-08
Existing studies have shown that the blood levels of several biologically-related molecules are related to the risk of Alzheimer’s disease and wider dementia, but at present, we still lack information about all changes in the plasma proteome in the previous years of dementia.
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Cancer Discovery: Finding the weakness of drug-resistant colorectal cancer: WRN gene is expected to become a new target for the treatment of drug-resistant colorectal cancer
Time of Update: 2021-06-04
Werner helicase is a synthetic-lethal vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy and Immunotherapy.
Werner helicase is a synthetic-lethal vulnerability in Mismatch Repair-Deficient Colorectal Cancer Refractory to Targeted Therapies, Chemotherapy and Immunotherapy.
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Clinical Nutrition: Early hypozincemia in patients with COVID-19 is associated with increased risk of serious complications
Time of Update: 2021-05-20
This study aims to assess the impact of hypozincemia and the early prevalence of new coronary pneumonia ( COVID-19 ), as well as its prognostic value in predicting hospitalization due to respiratory complications within 10 days.
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Up-regulation of histone deacetylase 6 is associated with the malignancy of melanoma and the prognosis of patients
Time of Update: 2021-04-14
In recent years, more and more researchers have devoted themselves to exploring the biological characteristics of melanoma, but there are no clinical biomarkers that can predict the occurrence and development of melanoma.
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Schizophrenia is associated with abnormal connections between the small brain and brain function
Time of Update: 2021-02-10
China Institute of Psychology Mental Health Key Laboratory Researcher Chen Chu overseas led a team of neuropsychology and applied cognitive neuroscience (NACN) in the early study found that schizophrenia patients and their unilever siblings in sensory integration processing there is a lack of activation of the brain, and the cer cerebral activation is significantly inheritable.
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Algorithms and Methods for Correlating Experimental Results with Annotation Databases
Time of Update: 2020-12-24
These genes, or at least a subset of them, are key biomarkers and are thought to be important to describe and understand the analyzed biological system (the pathology) at a molecular level.
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Chinese scholars have found that intestinal microbial disorders are linked to severe depression, science advances
Time of Update: 2020-12-17
the study included 311 subjects, including 156 MDD patients and 156 general subjects, and collected 311 stool samples for comprehensive analysis of enterovirus, bacterial microorganisms and fecal metabolism.
Bacteroides may lead to increased levels of cytokines and associated inflammation in patients with MDD, the researchers said.
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Biomarkers of Oxidative Stress: Methods and Measures of Oxidative DNA Damage (COMET Assay) and Telomere Shortening
Time of Update: 2020-12-09
Telomere length measured by Southern blotting technique allows one to estimate the chronic burden of oxidative stress at the molecular level and is now considered as biomarker of biological aging.
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Induction of Cytochrome P4501A (CYP1A) in Fish A Biomarker for Environmental Pollution
Time of Update: 2020-11-24
Inducible proteins are attractive candidates for biomarkers-i.e. biological responses that reflect exposure to, or effects of, environmental pollutants in an organism ( 1 ). Blomarkers are increasing
