ARD: biological insights into systemic lupus erythematosus from immune cell-specific transcriptome association studies
Time of Update: 2022-08-16
OBJECTIVE : Genome-wide association studies (GWAS) have identified more than 100 systemic lupus erythematosus (SLE) risk loci, but disease genes at most loci remain unclear, hindering translation of these gene discoveries .
Sanofi's Sarclisa combination therapy has significant efficacy in the treatment of multiple myeloma
Time of Update: 2022-08-15
The trial is evaluating the addition of the CD38-targeting antibody Sarclisa (isatuximab) to the proteasome inhibitor Kyprolis (carfilzomib, cardinal) in patients with relapsed multiple myeloma (MM) who have received 1-3 prior anti-myeloma treatments.
The latest forecast of Lanzhou University: This round of local epidemic is expected to infect 35,000 people and be brought under control in early April
Time of Update: 2022-04-19
On March 9, American scholars published an article on medRxiv, confirming that Delta Chron appeared in the United States, providing evidence of co-infection and recombination of Delta and Omicron, confirming the existence of a new strain .
Scientists use primate stem cells to grow sperm cells
Time of Update: 2021-11-03
This study, recently published in the journal Fertility and Sterility Science, shows for the first time that primate embryonic stem cells can produce functional sperm cells in a petri dish .
Collaborators include Jon Hennebold of the National Primate Research Center of Oregon and Kyle Orwig and Gerald Schatten of the University of Pittsburgh .
The most complete summary: how much do you know about the four star indicators of inflammation markers
Time of Update: 2021-10-01
Being good at reviewing and summarizing is conducive to the formulation of new plans and new goals, as four star indicators of inflammation markers: C-reactive protein (CRP), serum amyloid A (SAA), procalcitonin (PCT), white blood cells How has interleukin-6 (IL-6) performed in recent years?
ARD: Are the B cells of patients with chronic cutaneous lupus erythematosus the same
Time of Update: 2021-09-29
CCLE is immunologically heterogeneous, including a part of B cell composition like SLE , and its clinical manifestations are also related to increased levels of autoantibodies and more extensive skin damage Source:Jenks SA, Wei C, Bugrovsky R, Hill A, Wang X, Rossi FM, Cashman K, Woodruff MC, Aspey LD, Lim SS, Bao G, Drenkard C, Sanz I.
Stroke: extracellular vesicle related indicators, which can assist in the diagnosis of transient ischemic attack
Time of Update: 2021-09-03
EVs are secreted nano-sized particles, it plays an important role in the communication between cells in the immuneIn this way, Jacopo Burrello of MD, Neurocenter of Southern Switzerland and others explored the surface-antigen profile of EVs in patients with suspected TIA symptoms .
Cell: The pathogenesis of neonatal biliary atresia has been revealed, and rituximab may become a potential therapeutic drug
Time of Update: 2021-08-26
. Subsequently, the yolk sac and aortic stem cells migrate to the fetal liver, and the hematopoietic function of the fetal liver reaches its peak at 7-17 weeks and declines at about 20 weeks .
Infection with the new crown may affect intelligence, the third shot of Coxing and Pfizer vaccination can significantly increase antibody titers. Progress in research on new crowns
Time of Update: 2021-08-13
4%Source: NEJMSource: NEJM Source: NEJMOn July 28, a study published in the New England Journal of Medicine (NEJM) published the results of a real-world study in Israel, showing that medical staff had a breakthrough infection after being completely vaccinated with the BNT162b2 vaccine (nucleic acid test results after the second dose of vaccine Positive) symptoms are mild or asymptomatic, and the protective efficacy of the vaccine is closely related to the peak titers of neutralizing antibodies in the body .
PVRIG and TIGIT combined with PD-1 for the treatment of solid tumors, completed the first patient drug delivery
Time of Update: 2021-08-05
Recent popular reports from Yimaike★Global leader! Bangyao Biological Announces Preliminary Data from Multi-center Clinical Research on Gene Therapy of ThalassemiaYimai Meng broke the news ★Two South
Zejing Pharmaceutical's Class 1 new drug ``Donafinil Tosylate Tablets'' will soon be approved for advanced hepatocellular carcinoma
Time of Update: 2021-06-05
This new drug marketing application is mainly based on the results of an open, randomized, parallel controlled, multi-center phase II/III clinical study of Donafenib tosylate tablets for the first-line treatment of advanced hepatocellular carcinoma (trial code ZGDH3).
The first EZH2 inhibitor approved by the FDA is applied for clinical application in China
Time of Update: 2021-06-02
The results of the study showed that the ORR of Tazemetostat in EZH2 mutant patients was 69%, of which CR was 12%, PR was 57%, and mDOR was 10.
Time of Update: 2021-03-13
The 1st species is Vibrio, the cells are short, only once bent, arced, such as cholera bacteria, the 2 species is helicobacteria, the cells are 2 times or more Bending, spiral, tougher, such as small screw bacteria, type 3 is a helix, cells 2 or more bent into a spiral, cells soft, such as European regression heat dredging helix.
The clinical results of BCMA targeted therapy were positive
Time of Update: 2021-03-08
The latest clinical results published by ASH show that among patients treated with the recommended dose of teclistamab in phase 2 clinical trials of subsulte injection form, ORR reached 73% (16/22), of which 55% achieved very good partial remission (VGPR) and 23% achieved complete remission (CR).
Mannose-6-Phosphate: A Regulator of LLO Destruction
Time of Update: 2021-02-27
Oligosaccharyltransferase (OT) catalyzes the signature reaction of the asparagine-linked glycosylation pathway, namely, the transfer of preformed glycans from the lipid-linked oligosaccharide Glc3Man9GlcNAc2-P-P-Dolichol (G 3 M 9 Gn 2 -LLO) to appropriate asparaginyl residues on acceptor polypeptides.