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Domestication of overactive mTOR in renal cell carcinoma
Time of Update: 2023-02-03
Increased localization of TFEB/TFE3 nuclei in Tsc2-deficient mouse kidney tumorsIn a new study from the Johns Hopkins University Kimmel Cancer Center, researchers describe a novel mechanism of kidney cancer tumor formation driven by overexpression of mechanistic targets of the rapamycin complex 1 (mTORC1) signaling pathway leading to deletion of tumor suppressor genes in the tuberous sclerosis complex (TSC).
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Resolving the genetic drivers of head and neck cancer
Time of Update: 2023-01-06
"We found that not only the 9p21 locus on chromosome 9p is involved, but also the 9p24 locus, which may be more important in driving resistance in immune checkpoint therapies; Surprisingly, we found that an increase in these gene regions, at least in the case of HPV-negative head and neck squamous cell carcinoma, was associated with ICT survival benefits.
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Resolving the genetic drivers of head and neck cancer
Time of Update: 2023-01-06
"We found that not only the 9p21 locus on chromosome 9p is involved, but also the 9p24 locus, which may be more important in driving resistance in immune checkpoint therapies; Surprisingly, we found that an increase in these gene regions, at least in the case of HPV-negative head and neck squamous cell carcinoma, was associated with ICT survival benefits.
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Eur Urol Oncol: In penile cancer, how does mixed tracer-guided sentinel lymph node recognition perform
Time of Update: 2022-11-04
Oct 2022 Studies have shown that mixed indocyanine green (ICG)-99mTc-nanocolloid tracer improves sentinel lymph node (SN) recognition compared to traditional dynamic sentinel lymph node biopsy (DSNB).
Oct 2022 Studies have shown that mixed indocyanine green (ICG)-99mTc-nanocolloid tracer improves sentinel lymph node (SN) recognition compared to traditional dynamic sentinel lymph node biopsy (DSNB).
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Efficiently distinguishing between good and malignant lung nodules, this new method may be tried
Time of Update: 2022-10-03
Figure 4 PulmoSeek Plus model clinical net benefit study results Finally, Professor Liang pointed out: "This study shows that DNA methylation, clinical features and imaging features multi-dimensional biomarkers combined to diagnose good and malignant lung nodules, which not only have high accuracy, but also reduce the burden on patients, which is worth using in subsequent clinical decisions.
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JAMA Oncology: Fertility preservation surgery does not increase the risk of breast cancer recurrence
Time of Update: 2022-09-09
Corresponding author Kenny Rodriguez-Wallberg, adjunct professor in the Department of Oncology Pathology at Karolinska Institutet, said: "We did not find an increased risk of recurrence or death in women who did not undergo fertility preservation surgery.
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Science sub-journal: Scientists reveal for the first time the mechanistic link between circadian clock disturbance and colorectal cancer
Time of Update: 2022-08-20
Taken together, these data suggest that disruption of the circadian clock drives APC LOH over-activation of Wnt signaling and enhances myc-dependent glycolytic metabolism to accelerate colorectal cancer progression .
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The continuous promotion of direct settlement of medical insurance across provinces and different places greatly reduces the pressure on patients to advance funds
Time of Update: 2022-08-15
1893 million person-times According to the data provided by the National Medical Insurance Bureau, at present, the cross-provincial direct settlement of hospitalization expenses has reached 57,300 designated medical institutions, which basically cover all the first to third-level designated hospitals.
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Let the "beautiful killer" no longer run rampant
Time of Update: 2022-03-02
Since then, the center has proposed a "Chinese plan" for triple-negative breast cancer combined with capecitabine adjuvant chemotherapy, which significantly improved the 5-year disease-free survival rate of triple-negative breast cancer patients and effectively reduced the risk of recurrence by 41% .
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Prof. Gang Guo: Clinical value and timing of cytoreductive nephrectomy for metastatic renal cancer
Time of Update: 2022-02-23
Application and role of CN in the era of targeted combination therapy Checkmate9ER study: subgroup analysis results stratified by prior nephrectomy Checkmate9ER study aims to evaluate nivolumab + cabozantinib vs sunitinib in advanced stage Efficacy in kidney cancer .
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Alzheimer&Dementia: Cancer is not evil, it can actually reduce the risk of dementia
Time of Update: 2021-10-10
references:references:Investigating the association between cancer and the risk of dementia: Results from the Memento cohort.
12308Investigating the association between cancer and the risk of dementia: Results from the Memento cohort.
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The State Food and Drug Administration approves Baihuize for the treatment of patients with advanced ovarian cancer who have received treatment
Time of Update: 2021-07-07
The company announced today that the National Medical Products Administration (NMPA) of China has granted its PARP inhibitor Baihuize® (Pamiparib) conditional approval for the treatment of at least two lines of chemotherapy with germline BRCA ( gBRCA) mutations in patients with advanced ovarian cancer, fallopian tube cancer, or primary peritoneal cancer .
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Metz Tumor Progress Express (Issue 007
Time of Update: 2021-06-04
The results of this study showed that in high-risk locally advanced head and neck squamous cell carcinoma patients, adding avelumab to concurrent chemoradiation did not improve the progression-free survival of patients.
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The disease control rate of 90% mRNA cancer vaccine/Keytruda combination had positive early clinical results
Time of Update: 2021-02-24
mRNA-4157 was used in a phase 1 clinical trial to treat HPV-negative head and neck squamous cell carcinoma (HNSCC) patients with a total remission rate (ORR) of 50% (ORR) and a 9.8-month medium progressive survival (mPFS).
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The cancer hospital in the southern suburbs of Beijing resumed treatment on Feb. 2
Time of Update: 2021-02-02
According to the requirements of prevention and control, the relevant medical and security personnel and the overall environment and key parts of the hospital have been nucleic acid testing, the initial test results are negative.
