Cell: A novel mechanism by which microglia lead to increased Aβ deposition in Alzheimer's disease, neuropathological exacerbation, and cognitive deficits
Time of Update: 2022-11-25
Recent research has revealed the key role of microglia and their receptors in influencing the accumulation of Aβ protein and myelin debris in neurodegenerative diseases. But the key intracellular mole
A teenager eroded by "scoliosis
Time of Update: 2022-10-13
"10 years ago, because of scoliosis, I and Xiao Ding began to intersect, his condition was very serious, basically there was no hope of treatment, his family was very poor, the local medical resources were very poor, and no one in his area could give him orthopedic surgery on the spine, and I saw him as a more serious state.
J Clin Oncol: Toripalimab combined with chemotherapy for the treatment of advanced non-small cell lung cancer
Time of Update: 2022-10-12
Progression-free survival rates in both groupsAt the time of the final PFS analysis, PFS was significantly longer in the Toripalimab group than in the placebo group (median PFS: 8.
Give immunotherapy cells the elasticity to pass the "stress test
Time of Update: 2022-09-30
"By knocking out a single gene, the cells we create are not only effective tumor cell killers, but also more persistent killers over a long period of time," said Julia Carnevale, m.
ESMO Pre-"Research" Newsletter Atenolizumab: New Advances in the Field of Urinary Tumors
Time of Update: 2022-09-21
Abstract number: 1742P：Phase 2 study of rucaparib and atezolizumab (ARIANES): Results in patients (pts) with platinum-sensitive metastatic urothelial cancer (mUC) and metastatic castration-resistant prostate cancer (mCRPC)Research backgroundPolyADP ribose polymerase inhibitors (PARPi) modulate immunity by activating the innate immune pathway of cGAS/STING and inducing PD-L1 expression.
10× Single cell transcriptome common Q&A (II): experimental quality control correlation
Time of Update: 2022-09-14
Fig. 6 Single-cell library quality inspection peak diagram summary Figure 1 Schematic diagram of the phenomenon of transcription bursts under the microscope Figure 2 Overall flowchart of a single-cell experiment Figure 3 Pay attention to problems when cell isolation Figure 4 Chromium X cell sorting
Figure 5 10× single-cell flow Fig. 6 Single-cell library quality inspection peak diagram
Sevoflurane alleviates hypoxic-ischemic encephalopathy by regulating G9a expression. PC-12 (well differentiated) cells
Time of Update: 2022-08-30
"Bioengineered" IF: 3. 269The mechanism of sevoflurane post-treatment alleviating hypoxic-ischemic encephalopathy by affecting histone methyltransferase G9a in ratsLearning is boundless in the ocean,
CytoSMART Live Cell Imaging Microscope Omni Adds Organoid Analysis Module
Time of Update: 2022-08-30
Better models start with better platforms CytoSMART Omni's Organoid Analysis Module adds advanced organoid detection and quantification capabilities to a versatile imaging platform, enabling researchers to: Study long-term developmental processes without labeling cultures
One article to understand the competitive landscape of the domestic biosimilar drug market
Time of Update: 2022-08-12
Geleli (Adalimumab biosimilar ) Pubixic (bevacizumab biosimilar) Judging from the sales performance of the currently listed biosimilar drugs, they have achieved doubled performance growth, and the gross profit margin is quite high.
Cardiovasc Diabetol: TyG Index as a Surrogate for Cardiovascular Risk Stratification in Cancer Survivors
Time of Update: 2022-05-20
In conclusion, the TyG index can be used as a simple surrogate for risk stratification of future cardiovascular disease events (especially atherosclerotic subtypes) in cancer survivors .
The TyG index may serve as a simple surrogate for risk stratification of future cardiovascular disease events (especially atherosclerotic subtypes) in cancer survivors .
WuXi Junuo: The marketing application for the second indication of CD19 CAR-T was accepted by the State Food and Drug Administration
Time of Update: 2022-05-02
This is WuXi Junuo's second marketing authorization application for Benoda® and is expected to be the first cell therapy product approved in China for the treatment of patients with r/r FL .
116 million yuan
Time of Update: 2022-04-30
In the past year, his annual salary exceeded 18 million US dollars; GSK CEO Emma Walmsley's income in 2021 will also follow suit.
With the improvement of GSK's performance, he received a 17% salary increase; Novartis CEO Vas Narasimhan received 9 million Swiss francs of performance compensation for exceeding expectations .
More than 1.2 million CAR-T needles or price cuts
Time of Update: 2022-04-27
Judging from the number of product approvals, domestic tumor immunotherapy closely follows the pace of international development and has become the second largest market after the United States, and there are still more than 500 cell therapy projects in the clinical research stage .
Clin Trans Gastroenterology: Fatty liver associated with metabolic dysfunction increases colon cancer risk
Time of Update: 2022-03-04
Nonalcoholic fatty liver disease (NAFLD) is frequently associated with metabolic dysfunctions such as type 2 diabetes (T2DM) and obesity, which are significantly associated with increased risk of cardiovascular events and cancer .
Chromosome-level genome assembly of human fungal pathogens reveals collinearity between geographically different species
Time of Update: 2022-01-07
This study provides an important resource for fungal researchers and further emphasizes the importance of chromosome-level assembly in the analysis of high-throughput data sets .