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Mechanoregulation of the RNA-binding protein hnRNPC in a failed heart
Time of Update: 2023-01-05
Mechanical regulation helps clarify heart failuresummaryHeart disease is characterized by a strong remodeling of the extracellular matrix (ECM), which eventually leads to heart failure.
Mechanical regulation helps clarify heart failuresummaryHeart disease is characterized by a strong remodeling of the extracellular matrix (ECM), which eventually leads to heart failure.
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Nature sub-issue: MIT's newly developed CRISPR-based "paste" tool
Time of Update: 2023-01-05
"Drag-and-drop genome insertion of large sequences without double-strand DNA cleavage using CRISPR-directed integrases Building on the CRISPR gene-editing system, MIT researchers have devised a new tool that can cut out defective genes and replace them with new ones in a safer and more efficient way.
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New Review: Research Status and Future Development of Precision Medicine in Type 2 Diabetes
Time of Update: 2023-01-04
On November 1, 2022, The Lancet published an authoritative review "Type 2 diabetes" online, Professor Ehtasham from the Diabetes Research Center of the University of Leicester and the NIHR Biomedical Research Center of Leicester focused on the current new therapeutic targets of type 2 diabetes, described the research status and future development of precision medicine in type 2 diabetes, and took us to understand the treatment and management of type 2 diabetes from a new perspective.
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A leap forward in personalized cancer therapy! CRISPR-engineered T cells for clinical trials
Time of Update: 2022-11-26
They isolated T cells from 16 patients, most of whom had colorectal cancer, and used CRISPR to convert their endogenous T cell receptor (TCR) genes into genes that were more specific for cancer, allowing immune cells to better target tumors.
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Do you know the risk factors for vertigo? Come and test
Time of Update: 2022-11-01
Question twoWhich of these drugs is most likely to cause dizziness or vertigo?A.
Question twoWhich of these drugs is most likely to cause dizziness or vertigo?A.
Question twoWhich of these drugs is most likely to cause dizziness or vertigo?A.
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【One case per day】 Cysticercosis cerebral cysticercosis
Time of Update: 2022-10-12
Caused by pork tapewormThe most important manifestation of the disease in the central nervous system - neurocysticercosis (NCC)3.
Caused by pork tapewormThe most important manifestation of the disease in the central nervous system - neurocysticercosis (NCC)3.
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NEJM: therapeutic effect of different antiviral agents on the Omicron subvariant BA.2.75
Time of Update: 2022-10-12
Table 1 Efficacy of monoclonal antibodies and antiviral drugs on in vitro Omicron subvariantsREGN10987 (sold as imdevimab) loses its neutralizing activity on BA.
Table 1 Efficacy of monoclonal antibodies and antiviral drugs on in vitro Omicron subvariantsREGN10987 (sold as imdevimab) loses its neutralizing activity on BA.
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Treatment Essentials for Ulcerative Colitis in Adults (Part 2) 2022 PANCO Clinical Practice Guidelines Recommended at a Glance
Time of Update: 2022-10-03
(Recommended level: strong; Quality of the evidence: low) Practice points: In patients with mild to moderate UC, no difference was found in the maintenance of remission with conventional or extended-release oral mesalazine at equivalent doses.
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Professor Cai Zhen: The clinical significance of MRD in MM treatment
Time of Update: 2022-10-01
The prognostic value of MRD assessment is substantial1MRD negative prognostic value is higher than CR, which is an effective predictor of PFS benefitA pooled analysis of three PETHEMA/GEM trials for the newly diagnosed multiple myeloma (NDMM)[9] showed that a negative MRD provided a better prognostic outcome than traditional efficacy assessment (Figure 2).
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Management of benign liver lesions: focal nodular hyperplasia and hepatocellular adenoma
Time of Update: 2022-10-01
3. For female patients with HCA, surgical resection is recommended if the HCA is still ≥ 5 cm after 6 months of discontinuation of oral contraceptives, or has malignant features on imaging, or histically confirmed β-catenin mutations [Very low quality of evidence (D); Recommended intensity 2 (conditional recommendation)].
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Researchers propose a predictive method for predicting the efficacy of neoadjuvant chemotherapy for advanced gastric cancer
Time of Update: 2022-10-01
Gastric cancer is a common malignant tumor originating from the epithelial epithelium of the gastric mucosa, its early symptoms are insidious and non-specific, often similar to the symptoms of chronic
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Effect of PNAS exercise hormones on parkinson's symptoms
Time of Update: 2022-09-21
To test the effects of irisin on Parkinson's disease, the team started with a research model used by Dawson, where mouse brain cells were designed to spread small, elongated fibers that spread α—the synuclein,a protein associated with the brain neurotransmitter dopamine that regulates mood and movement.
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Suvotinib treatment of EGFR exon20ins NSCLC China Registered Clinical Attainment Primary Endpoint
Time of Update: 2022-09-14
" The 2022 Annual Meeting of the European Society of Oncology (ESMO) announced that suvotinib reached the primary endpoint of WU-KONG6 in patients with advanced non-small cell lung cancer (NSCLC) who had previously received platinum-based chemotherapy and carried EGFR exon20ins, with encouraging clinical results.
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European Radiology: 3T MR neuroimaging of the lumbosacral plexus with ATTRv-PN
Time of Update: 2022-09-06
Compared with AVC, ATTRv-PN patients had significantly more frequent intraneural signal increases in LSP roots on T2WI images (ratio=3.
Compared with AVC, ATTRv-PN patients had significantly more frequent intraneural signal increases in LSP roots on T2WI images (ratio=3.
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Circulation: Exercise this number per week with the lowest risk of death
Time of Update: 2022-08-19
Coincidentally, in a recent study published on Circulation, entitled "Long-Term Leisure-Time Physical Activity Intensity and All-Cause and Cause-Specific Mortality: A Prospective Cohort of US Adults", more than 100,000 people were Combined, the researchers explored the association between exercise duration and risk of death .
