Lab-grown "mini-eyes" unlock understanding of blindness, a rare genetic disease
Time of Update: 2023-01-05
Molecular pathology of Usher 1B patient-derived retinal organoids at single cell resolution Researchers at the Great Ormond Street Institute for Child Health (UCL GOS ICH) at University College London have developed "mini-eyes", which make it possible to study and better understand the development of blindness in a rare genetic condition, Ushel syndrome.
Annual Inventory: Top 10 M&A Transactions in the Global Healthcare Sector in 2022
Time of Update: 2023-01-01
6 billion US dollars, of which CSL, a leading Australian blood product and vaccine company, acquired Vifor for 117 US dollars Pharma became the largest M&A event of the year, with Pfizer, United Health and GlaxoSmithKline accounting for 70% of the top 10 M&A events.
The diagnosis and treatment points of myocarditis and the latest progress in treatment—an in-depth review
Time of Update: 2022-10-14
Compiled and sorted out, please do not reprint without authorization. Lead Myocarditis is a non-ischemic inflammatory disease of the myocardium caused by viruses and various autoimmune diseases. The n
ESMO Big Name Review & i Hope Time: An Exploration of the "Best" Nodes in EGFR TKI Conversion Therapy
Time of Update: 2022-09-21
Professor Qin Haifeng, founder of i Hope Medicine, invited Professor Wang Jun of the First Affiliated Hospital of Shandong First Medical University to interpret the study, as follows:EORTC Lung Cancer Group 1613 APPLE study detailsProfessor Jordi Remon MasipbackgroundPrior to 2016, first- and second-generation EGFR TKIs were first-line treatment options for patients with EGFR-sensitive mutations with NSCLC, with limited options after treatment progression.
Yimeitongde and 10x sincerely invite you to participate in the National Cancer Cytology Annual Conference
Time of Update: 2022-08-30
Special report: Single-cell and spatial multi-omics open a multi-dimensional perspective of tumor research Conference overview: Conference Name: The 3rd National Cancer Cell Biology Annual Conference 2022Conference Time: August 5th - August 8thVenue: Changchun Fifth Ring International Hotel (Intersection of Jilin Road and Dongsheng Street, Erdao District, Changchun City, Jilin Province)Conference Introduction:
Haematologica: Mutations in RXRA renew interest in retinoids for acute myeloid leukemia
Time of Update: 2022-04-22
In APL, a subtype that accounts for 5% of AML cases, a combination of two targeted agents, all-trans retinoic acid (ATRA) and arsenic trioxide, cured more than 90% of AML through PML-RARA driver degradation, differentiation and recovery Patients with PML-dependent aging .
Cancer Cell The determinants of whether patients with renal clear cell carcinoma respond to anti-PD-1
Time of Update: 2021-12-04
TCR analysis revealed that responders had a higher number of amplified TCR clones before treatment, indicating the occurrence of an immune response .
Differential gene expression analysis showed that nivolumab treatment increased T cell infiltration in both responders and non-responders.
"Nature Medicine" Obesity and hyperinsulinemia promote fat cells to activate cell cycle programs and aging
Time of Update: 2021-11-13
However, chronic hyperinsulinemia induced in vitro or in human diseases is associated with subsequent cell cycle exit, leading to premature aging of the transcriptome and secretion profile of adipocytes .
By proving that adipocytes can activate the cell cycle program, this is a mature mechanism of human adipocyte aging .
The Huang Tiejun research group of the School of Information publishes an article in the Cell sub-publishing to reveal the mechanism of biological retina encoding dynamic natural scenes
Time of Update: 2021-11-04
In order to break through the above-mentioned bottleneck, the research group of Professor Huang Tiejun from the Department of Computer Science and Technology of Peking University and the National Engineering Laboratory of Digital Video Coding and Decoding Technology proposed and implemented a retinal coding model based on convolutional recurrent neural network, which can predict with high precision.
Research on New High-efficiency Antibacterial Powder Coating
Time of Update: 2021-06-04
The results showed that the antibacterial effect of the antibacterial agent compounded with silver ions and zinc ions with a glass network structure is the best; the powder coating with internal extrusion and external mixing has excellent antibacterial performance; the obtained coating is treated at high temperature and washed with water.
Sub-Journal of "Nature": There are "zombie genes" in the brain. People die, but they live
Time of Update: 2021-04-23
Selective time-dependent changes in human brain activity and cell-specific gene expression after death Next, the researchers performed histological observations on brain tissue samples within 24 hours of brain death and discovered three types of genes.
Chemical Proteomics Profiling of Proteasome Activity
Time of Update: 2020-12-26
Here, a set of chemistry-based functional proteomics techniques is demonstrated by profiling the multi-catalytic protease activities of the proteasome.
Importantly, functional profiling is complementary to expression level profiling and is an indispensable parameter for better understanding of mechanisms underlying biological processes.
In Vivo Run-On Assays to Monitor Nascent Precursor RNA Transcripts
Time of Update: 2020-12-21
This assay allows direct monitoring of active transcription foci in living cells.
Therefore, the assay we present here is a sensitive analytical tool to monitor the topology of transcription foci in the eukaryotic cell nucleus and to gain insight into transcription rates.
Blood: Factors related to the prognosis of new coronavirus infection in patients with multiple myeloma
Time of Update: 2020-12-12
bone marrow transplants, even in COVID-19 infections, had no significant correlation with prognostics; multivariable analysis found that only age, high-risk MM, kidney disease and MM poor control are still independent predictors of poor prognosis of COVID-19 infection.
Allogeneic bone marrow plus peripheral blood stem cell hybrid transplant treatment leukemia
Time of Update: 2020-07-03
, the PLA General Hospital the first affiliated Hospital hematology using allogeneic bone marrow stem cell mixed cell transplantation technology, so that a female suffering from chronic granuloc