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Cell Shanghai Drug reveals the structural basis of the mechanism of action of the potent analgesic fentanyl and morphine
Time of Update: 2023-01-06
On November 10, 2022, the team of Xu Huaqiang/Zhuang Youwen, Xie Xin and Wang Mingwei of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences cooperated to publish a research paper e
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Cell Shanghai Drug reveals the structural basis of the mechanism of action of the potent analgesic fentanyl and morphine
Time of Update: 2023-01-06
On November 10, 2022, the team of Xu Huaqiang/Zhuang Youwen, Xie Xin and Wang Mingwei of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences cooperated to publish a research paper e
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Neuron: The role of cardiovascular pressure reflex circuits in sleep control
Time of Update: 2022-11-25
The authors found that optogenetic activation of GABAERGIC neurons in the CVLM region of GAD2-cre mice resulted in a significant increase in NREM sleep, in addition to a decrease in blood pressure and heart rate (Figures 5B, 5F).
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Issue 45/2014 - EU proposes to amend new emissions regulations
Time of Update: 2022-11-13
(Xiaohua) On October 7, the European Union Committee of Household Appliance Manufacturers (CECE) issued an announcement to revise the exhaust emission regulations.
(Xiaohua) On October 7, the European Union Committee of Household Appliance Manufacturers (CECE) issued an announcement to revise the exhaust emission regulations.
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The Nature sub-journal breaks with conventional wisdom and discovers new mechanisms for immune system longevity
Time of Update: 2022-10-03
essayIntercellular telomere transfer rescues T cells from senescence and promotes long-term immunological memory An international team led by scientists at University College London has discovered a new mechanism that can slow or possibly stop natural aging of immune cells – one of the nine hallmarks of aging.
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Application of timsTOF Pro dual TIMS/PASEF separation technology in proteomics
Time of Update: 2022-08-30
Let's have a look!Case number oneA study published in Metabolites titled "Proteomic Analysis of Tears and Conjunctival Cells Collected with Schirmer Strips Using timsTOF Pro: Preanalytical Considerations" using timsTOF Pro for proteomic analysis of tear and conjunctival cells highlights the combination of high data The acquisition speed and ion mobility-based separation in timsTOF Pro can bring a new dimension to the study of biomarkers in limited samples such as tears [1] .
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Nat Cell Biol Zhu Xiaofan/Gu Jin/Cheng Tao team collaboration revealed the essence of leukemia minimal residual disease for the first time
Time of Update: 2022-03-08
By comparing the single-cell transcriptome data of leukemia cells in three stages of initial diagnosis, D19 and relapse, the authors found that the differentiation stage of residual leukemia cells has no significant characteristics, but the cell cycle is more in a quiescent state, and the hypoxia signaling pathway is significantly activated .
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"Cell" Gut fungi affect neuroimmunity and behavior
Time of Update: 2022-03-05
"We have established a direct link between major immune pathways induced by fungi in the gut lining and nervous system signals that influence animal behavior," said senior author Iliyan Iliev, PhD, medical immunology in gastroenterology and hepatology Associate Professor and member of the Jill Roberts Institute for Inflammatory Bowel Disease at Weill Cornell Medicine .
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Cell Rep: Causes of high-risk women with ovarian cancer
Time of Update: 2022-01-09
Clive Svendsen, executive director of the Institute of Regenerative Medicine of the Cedars-Sinai Board of Directors, explained: “We use cells from women with BRCA-1 mutations in ovarian cancer to create these ovarian organoids .
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Use CRISPR technology to modify tumor cells in situ and reshape macrophages to achieve effective tumor immunotherapy
Time of Update: 2022-01-08
722 ) in the field of nanotechnology published an online publication titled " CRISPR-based in situ engineering tumor cells to reprogram macrophages for effective cancer" " Immunotherapy " (using CRISPR technology to modify tumor cells in situ to reshape macrophages to achieve effective tumor immunotherapy) research results .
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Positive progress in tumor electric field therapy for lung cancer Zai Lab owns rights in Greater China
Time of Update: 2021-05-02
Today, Novocure announced that its Tumor Treating Fields (TTF) has made positive progress in a pivotal Phase 3 clinical trial for the treatment of patients with non-small cell lung cancer.
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The latest data! Can this DMD gene therapy, which has been suspended for more than a year, effectively improve the patient's condition 丨 Yimai Meng broke the news
Time of Update: 2021-03-26
MedClub broke the news March 25, 2021/eMedClub News/--Recently, at the MDA virtual clinical and scientific conference, Solid announced the latest clinical research results for Duchenne muscular dystrophy (DMD).
Participants who successfully registered for the Shanghai 2021 BPIT conference will receive a limited edition of "CAR-T Cell Therapy Industry Research Report" 2021.
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An immune cell helps maintain motor endurance
Time of Update: 2021-03-09
a new study from Tohoku University in Japan has found that an immune cell is essential to maintaining athletic endurance.
They show that neophils, an immune cell that builds up in the muscles during exercise, play an important role in maintaining motor endurance.
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Scientists have revealed new mechanisms for DHA to promote neurodevelopment and function in the brain
Time of Update: 2021-03-02
Combined with experiments such as somatic gene manipulation (genetically modified mice, viral injections, embryonic electroplation, etc.), pharmacology, fluorescent dye microinfraction, RNA sequencing, electrophysiology and behavior of brain tablets, the study found that the free DHA in the brain regulates the development of synapses and functional synapses through the signal path of RXRA dependence, analyzes the new mechanism of DHA to promote brain development and function, and provides new ideas for the treatment of related diseases.
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The Preparation of Phenyl-stilbene Derivatives Using the Safety Catch Linker
Time of Update: 2021-02-26
One ion channel that controls lymphocyte differentiation is the highly T cell specific Kv1.3 channel.
Since the discovery of Kv1.3 channels in T c cells, these lymphocyte channels have been targeted in developing immunomodulatory drugs that might exhibit lower toxicities than those currently in use ( 1 , 2 ).
