Nature: It can prevent AIDS, but also strengthen the brain and enhance memory
Time of Update: 2022-08-11
On April 25, 2022, a newly published paper in Nature showed that increased expression of CCR5, the receptor used by the HIV virus to invade human cells, resulted in impaired memory connections in older individuals, and knocking out the CCR5 gene or using an FDA-approved inhibitor A drug that can reverse age-related memory decline opens up new ways to enhance memory and improve memory decline and loss in old age .
STTT Huazhong University of Science and Technology Huang Liang/Zhou Jianfeng Discovers Better Potential Treatment for TP53 Altered Aggressive B-Cell Lymphoma
Time of Update: 2022-06-16
In ZUMA-1, axicabtagene ciloleucel (Axi-cel), a first-in-class CD19-targeted CAR (CAR19) T cell product, achieved in r/r aggressive B-NHL following ≥2 lines of systemic therapy An objective response rate (ORR) of 82% and a median overall survival (OS) of greater than 2 years .
Senti Bio Announces New Advances in Next-Generation CAR-NK Therapy to Challenge AML Early data are encouraging
Time of Update: 2022-02-24
SENTI-202 combines FLT3 OR CD33 with an EMCN NOT-gated gene circuit and is designed to broadly target FLT3 and/or CD33-expressing AML tumor cells (including leukemia stem cells and immature leukemia blast subpopulations), but not healthy Hematopoietic stem cells (HSC) .
US$2.3 billion to help develop ready-to-use natural killer cell therapy Kite to reach a partnership
Time of Update: 2021-09-07
This collaboration will combine Shoreline's deep expertise in induced pluripotent stem cell (iPSC) differentiation and gene reprogramming, and Kite's extensive cell therapy development technology, commercialization and production capabilities to jointly develop a series of innovations for the treatment of hematological malignancies Allogeneic (allogeneic) candidate therapy .
Thermo Fisher launches a new extended gene therapy portfolio to support more effective adeno-associated virus preparation
Time of Update: 2021-08-08
Recently, Thermo Fisher Scientific has launched a set of solutions that support the production of adeno-associated virus (AAV) to help gene therapy developers quickly and efficiently scale production .
The new solution aimed at producing higher quality viral vectors simplifies the purification process, resulting in higher AAV yields .
Ineffective against mutant strains, Eli Lilly’s double antibody therapy was stopped
Time of Update: 2021-08-03
[Text/Observer Net Tao Meng, Zhou Yi, Editor/Zhou Yuanfang]Because of its ineffectiveness against some mutant strains, Eli Lilly’s "dual antibody therapy" was temporarily suspended in the United States .
In vitro studies have shown that this "dual antibody therapy" is currently unable to provide effective treatment for new variant strains .
The Polymerase Chain Reaction (PCR): General Methods
Time of Update: 2021-01-18
PCR utilizes components of the cellular machinery of mitotic cell division in vitro which respond predictably to user inputs.
This chapter introduces the principles of PCR and discusses practical considerations from target sequence definition through to optimization and application.
Neural stem cells secrete PTN to promote the development of their children's newborn neurons
Time of Update: 2020-08-06
Guo Weixiang of the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences, through cell removal, retrovirus-mediated single-cell markers, and signalpath regulation, found that neural stem cells can continue to provide Pleiotrophin (PTN) ligandtos to promote the development of their children's newborn neurons.
Cell . . . Insomnia can cause death through the accumulation of reactive oxygen in the intestines
Time of Update: 2020-07-21
Katherina as we all know, sleep is essential for survival. in the most primitive animals, there is an obvious similar sleep state. Severe sleep deprivation can cause fatal danger, but the underlying c
CD133-AKT-Wnt signal axis drives GBM stem cells
Time of Update: 2020-05-31
Cell surface markers play an important role in identifying tumor types and drug screening CD133 was originally used as a marker for identifying self-renewing hematopoietic and neural stem cell subgrou