Do human stem cells contain cancer-causing mutations
Time of Update: 2022-04-25
The research team's breakthrough will help ease the recent controversy over the genetic stability of human embryonic stem cells .
Recent studies have shown that human pluripotent stem cells have been shown to increase the frequency of severe cancer-causing mutations .
Cell Discovery: Epigenetic regulatory mechanisms in pancreatic ductal adenocarcinoma
Time of Update: 2022-03-06
Characterization of DNA methylation and chromatin status in pancreatic ductal adenocarcinoma tumor cells and normal epithelial cells(2) In pancreatic ductal adenocarcinoma tumor cells, DNA methylation in the promoter regions of hundreds of genes was strongly up-regulated, and the corresponding chromatin changed from an open state to a closed state, and showed a high degree of consistency in all patients .
Professor Zhang Liling: New progress and practice sharing of targeted therapy for peripheral T-cell lymphoma
Time of Update: 2021-12-30
The multi-center, single-arm phase II study of the dual SYK/JAK inhibitor Cerdulatinib monotherapy for relapsed and refractory PTCL showed that the overall response rate of ALCL and PTCL patients with the follicular helper T-cell lymphoma phenotype was higher than that of other subtypes.
The latest article from Shanghai Jiaotong University: A new mechanism for post-transcriptional regulation of the pathological process of Alzheimer's disease
Time of Update: 2021-10-01
Recently, the joint team of Professor Wang Hao from Shanghai Jiaotong University School of Basic Medicine and Professor Chen Hongzhuan from Shanghai University of Traditional Chinese Medicine published an online publication titled "Circular RNA Cwc27 contributes to Alzheimer's disease pathogenesis by repressing Pur-α activity" in the academic journal Cell Death & Differentiation under Nature.
A new study identifies genetic targets for stress hormones in the brain
Time of Update: 2021-08-14
In the leading research, scholars published in Nature Communications today (August 6th) at the University of Bristol and discovered the connection between steroid receptors-mineralocorticoid receptor (MR) and glucocorticoid Receptors (GR) and genes for neuroplasticity of cilia and hippocampus, areas of the brain related to coping with stress, learning and memory .
Capillary Electrophoresis with Detection by Laser-Induced Fluorescence
Time of Update: 2021-03-16
The importance of capillary zone electrophoresis (CZE) has been increasing in use for: structural analysis of plant cell walls, characterization of enzymes that degrade polysaccharides, and profiling of oligosaccharides to characterize cell wall mutants.
Here, we describe the instrumentation we use and the methods for attaching fluorescent labels to oligosaccharides so that they can be detected.
Scientists reveal how fever "armed" immune cells
Time of Update: 2020-12-21
Researchers at the Shanghai Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences found in mice that fever alters the surface proteins of immune cells, allowing them to reach the infected site better.
Quantitative Measurement of Cell-Cell Adhesion Under Flow Conditions
Time of Update: 2020-12-12
Cell-cell and cell-matrix contacts play an important role in immunological processes and tissue organization. It has been shown that in many cases, cell adhesion is mediated by specialized adhesion r
Capsaicin Accumulation in Capsicum spp. Suspension Cultures
Time of Update: 2020-11-18
Fruits of chili peppers ( Capsicum spp.) specifically synthesize and accumulate a group of analogs known as capsaicinoids in the placenta tissues.
Several efforts have been focused to investigate the biosynthetic capacity of in vitro chili pepper cells and tissue cultures in order to determine the production feasibility of these compounds at the industrial level under controlled conditions.
Tomatoes have been found to contain 10 times the antioxidant antioxidant vitae of ViC
Time of Update: 2020-10-02
researchers say grease acidification can reduce food quality, and that the super antioxidant inhibits the acidification of the oil, which can also be used in food supplements and functional foods; resveratrol is an antioxidant in red wine that slows cell aging and is 14 times more active than resveratrol.
Cancer New Antigen DNA Vaccine and Anti-Cancer T-Cell Immune Stimulation! VB10. NEO's joint treatment of head and neck cancer with bempeg shows great potential
Time of Update: 2020-09-09
August 16, 2020 // -- Two immuno-oncology companies,Vaccibody AS and Nektar Therapeutics, have jointly announced the evaluation of the individualized new antigen cancer vaccine VB10.NEO Joint CD12 Phase I/II clinical studies in patients treating patients with advanced head and neck squamous cell carcinoma (SCCHN) with the IL-2 pathogenic astigger bempegaldesleukin (bempeg) have been conducted in the first case of drug treatment.
PD-1 antibody "new helper" - BMI1 inhibitor
Time of Update: 2020-09-08
In this preclinical study, the team used a mouse model of head and neck squamous cell carcinoma that fully simulates the development and metastasis of human cancer, allowing researchers to track the genealogy of BMI1-positive cancer stem cells in an undisturbed tumor immune microencase.
Was Science issued a new issue of Neutralizing Antibodies on June 15th? 5 full articles
Time of Update: 2020-07-12
The outbreak of the new coronavirus continues to occur, and there are no specific drugs available for treatment of the disease But through the tireless efforts of global scientists, there has been a
The key to the treatment of breast cancer is to remove lmtk3 protein
Time of Update: 2017-11-20
British researchers have found a protein called lmtk3, which is not conducive to the inhibition of the expression of some breast cancer genes This study has made a great contribution to the treatment
The key role of three proteins in killing cancer cells
Time of Update: 2017-04-01
Recently, researchers at the University of Tel Aviv (tau) in Israel revealed the key role of three proteins in killing cancer cells in the Journal oncotarget The study was conducted by Malka of tau me