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Moderna2022: mRNA vaccine sales of $18.4 billion
Time of Update: 2023-02-01
English link: _mstmutation="1" _msthash="220727" _msttexthash="5471960"> On January 9, Moderna announced that its 2022 vaccine sales reached $18.
English link: _mstmutation="1" _msthash="220727" _msttexthash="5471960"> On January 9, Moderna announced that its 2022 vaccine sales reached $18.
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Cancer cell immune transformation nanotechnology platform
Time of Update: 2022-12-04
In this study, the researchers used BiTN with SLAMF7 and Her2-recognizing antibodies to target Her2-positive breast cancer cells.
In this study, the researchers used BiTN with SLAMF7 and Her2-recognizing antibodies to target Her2-positive breast cancer cells.
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Scientists use zebrafish to understand the link between the immune system and regeneration
Time of Update: 2022-10-01
A new study from the Stowers Institute for Medical Research used highly regenerated zebrafish to investigate the timing and genetic procedures of macrophages (a type of white blood cell) during the repair and regeneration of zebrafish sensory organs.
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Express blood test for cancer detection, early colorectal cancer screening test launched, with a sensitivity of 91
Time of Update: 2022-05-28
▎WuXi AppTec Content Team Editors Today, Guardant Health announced the launch of the Shield blood test to detect early signs of colorectal cancer in adults at average risk .
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Deletion of a single allele of the gene encoding Zbtb38 causes early embryonic death
Time of Update: 2022-05-19
"Our results show that germline deletion of Zbtb38 monoallelic reduces ectodermal cell proliferation shortly after embryo implantation and increases apoptosis, leading to early embryonic death .
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Nat Immunol Xue Haihui/Zang Chongzhi's team discovered the important regulatory role of Tcf1 transcription factor in T cell immune memory and secondary immune response
Time of Update: 2022-05-01
On February 21, 2022, the team of Professor Haihui Xue from Hackensack University Medical Center and the team of Professor Zang Chongzhi from the University of Virginia jointly published a paper entitled Tcf1 preprograms the mobilization of glycolysis in Nature Immunology The research paper in central memory CD8+ T cells during recall responses revealed the mechanism by which transcription factor Tcf1 regulates gene transcription during the secondary immune response of a memory immune cell.
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Ascletis Pharma's 2nd FASN Inhibitor Approved for Treatment of Advanced Solid Tumors
Time of Update: 2022-04-17
Article source: Medical Cube InfoA few days ago, CDE's official website showed that the clinical trial (IND) application of Ascletis' second fatty acid synthase (FASN) inhibitor ASC60 was approved by the Food and Drug Administration for the treatment of advanced solid tumors .
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"Immunity" Lactobacillus disrupts immunosuppression and stimulates tumor growth
Time of Update: 2022-03-07
The study found that lactic acid bacteria promote the growth of pancreatic duct cancer by activating tumor associated macrophages (TAMs) by metabolizing tryptophan in food .
The results showed that Lactobacillus activates AhR in tumor-associated macrophages by metabolizing tryptophan, which ultimately promotes pancreatic cancer growth and subverts the inhibitory effect of immune checkpoints .
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Nature sub-journal: 'kick and kill' strategy to eliminate HIV-infected cells
Time of Update: 2022-02-22
Jocelyn Kim said the strategy uses cells naturally produced by the immune system to kill infected cells that are hiding in the body and have may eradicate them .
In the new study, the researchers used SUW133 to flush HIV-infected cells out of hiding when mice were treated with antiretroviral drugs .
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Science: Reveal how cytotoxic T cells are reloaded with weapons and carry out multiple "kills
Time of Update: 2021-11-01
The relevant research results were published in the Science Journal on October 15, 2021, with the title of the paper "Mitochondrial translation is required for sustained killing by cytotoxic T cells" .
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Innovent announced the preliminary results of the Phase Ia dose escalation study of IBI315 (anti-Her2/PD-1 bispecific antibody) in patients with advanced solid tumors at the CSCO annual meeting
Time of Update: 2021-10-10
San Francisco, USA and Suzhou, China September 29, 2021/PRNewswire/ - Cinda Biopharmaceutical Group (Hong Kong Stock Exchange stock code: 01801), a company dedicated to R&D, production and sales for the treatment of tumors, metabolic diseases, A biopharmaceutical company that is an innovative drug for major diseases such as autoimmunity will report the preliminary results of a phase Ia clinical study of IBI315 (the world's first anti-Her2/PD-1 bispecific antibody) at the 2021 China Clinical Oncology Conference (CSCO) .
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MIT sets new targets for cancer vaccines
Time of Update: 2021-09-28
Researchers from the Massachusetts Institute of Technology (MIT) found that vaccination against certain cancer proteins can increase the overall T cell response in mice and help shrink tumors.
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"Cell Metabolism" obesity paradox: from fat cells will "call pain
Time of Update: 2021-09-04
Claire Crewe, one of the research leaders and assistant lecturer in internal medicine at UTSW, explained that the metabolic pressure of obesity gradually makes adipose tissue dysfunction, causing its mitochondria (the energy-producing organelles) to shrink and die .
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Protein Cell: Joint report by Chinese scientists: New coronavirus RNA does not have the ability to integrate into the host genome
Time of Update: 2021-08-27
Comprehensive analysis of RNA-seq and whole genome sequencing data reveals no evidence for SARS-CoV-2 integrating into host genome .
Comprehensive analysis of RNA-seq and whole genome sequencing data reveals no evidence for SARS-CoV-2 integrating into host genome in this message
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Cell Death Dis: Abnormal expression of oncogene ENC1 promotes breast cancer resistance to radiotherapy
Time of Update: 2021-08-13
All in all, the results of this study indicate that the overexpression of ENC1 is mediated by SE and downstream TCF4, which can enhance the Hippo/YAP1/TAZ signaling pathway .
